Alternative splicing of KRAS exon 4 promotes tumor progression via enhanced KRAS4A oncogenic activity [0.03%]
KRAS外显子4的可变剪接通过增强的致癌活性促进肿瘤进展
Namjoon Cho,Eunhye Kwon,Si-Eon Kim et al.
Namjoon Cho et al.
KRAS is a well-established oncogene that exhibits high-frequency mutations at cancer-driver hotspot loci across human cancers. While the oncogenic roles of mutant KRAS have been extensively investigated, the functional significance of KRAS ...
Hong-Yeoul Ryu,Mark Hochstrasser
Hong-Yeoul Ryu
The precision of the cell cycle is essential for organismal development, tissue homeostasis, and the prevention of malignancies. Cyclins and cyclin-dependent kinases (CDKs) play pivotal roles in regulating cell cycle progression. Recent stu...
RepID promotes metastatic potential in osteosarcoma through regulation of the PRC1-GATA6 axis [0.03%]
RepID通过调节PRC1-GATA6轴促进骨肉瘤的转移潜能
Dong-Hyun Jung,Jong-Uk Park,Jae-Hyun Jo et al.
Dong-Hyun Jung et al.
Osteosarcoma is the most common primary malignant bone tumor and is characterized by a high propensity for metastasis, most frequently to the lungs and lymph nodes. Despite extensive research, the key modulators and their functional roles d...
Ferroptosis-mediated anticancer activity of endoperoxide-containing steroids derived from Daedaleopsis confragosa via targeting NOS2 [0.03%]
来自Daedaleopsis confragosa的含内过氧化物类固醇通过靶向NOS2介导铁死亡的抗癌活性
Eun Jin Heo,Yeojin Kim,Jae Woong Chang et al.
Eun Jin Heo et al.
Mushrooms belonging to the genus Daedaleopsis are known to contain various biologically active constituents, including steroids. However, they have not been studied as extensively as other medicinal mushrooms. In this study, chemical analys...
Autophagy-driven MHC-I downregulation enables NK cell-mediated clearance of intracellular uropathogenic E. coli in urinary tract infection [0.03%]
自噬介导的MHC-I下调促进NK细胞清除泌尿道内源性尿路致病性大肠杆菌感染细胞
Manisha Naskar,Gyeongseo Suk,Hana Yoon et al.
Manisha Naskar et al.
Uropathogenic E. coli (UPEC) accounts for over 80% of urinary tract infections (UTIs) due to its distinct capacity to invade and persist within bladder epithelial cells (BECs). The ability of UPEC to survive for extended periods within BECs...
Presenilin 2 regulates corticosterone-induced autophagic death of adult hippocampal neural stem cells [0.03%]
早孕期暴露于皮质酮诱导的成年海马神经干细胞自噬死亡中早老素2的作用
Jihyun Hong,Hyun-Kyu An,Hyeri Nam et al.
Jihyun Hong et al.
Chronic psychological stress is a well-known risk factor for neurodegenerative diseases including Alzheimer disease (AD), yet the underlying mechanisms remain unclear. We previously showed that chronic stress impairs adult hippocampal neuro...
Recent progress in regulation of aging by non-coding RNAs in Caenorhabditis elegans [0.03%]
秀丽隐杆线虫中非编码RNA调控衰老的研究进展
Seungjae Hwang,Woojin Hong,Seung-Jae V Lee
Seungjae Hwang
Non-coding RNAs (ncRNAs) are RNA molecules that are not translated into proteins. Recent advances in RNA biology have uncovered roles of ncRNAs in physiological processes, including aging. Here, we review how various classes of ncRNAs regul...
Yu Gyung Kim,Kun-Hwa Kang,Hyo-Jin Song et al.
Yu Gyung Kim et al.
Oral lichen planus (OLP) is a chronic inflammatory condition characterized by CD8+ T cell-mediated apoptosis of oral epithelial cells. While psychological stress has been implicated in OLP pathogenesis, the underlying mechanisms remain uncl...
Long-read sequencing reveals novel transcript diversity in Polypterus senegalus [0.03%]
长读测序揭示Polypterus senegalus中的新型转录本多样性
Jeong Woen Shin,Bo-Mi Kim,Seung Hwan Lee et al.
Jeong Woen Shin et al.
Polypterus senegalus is a fish species characterized by primitive traits and unique physiological-anatomical features, representing a transitional stage toward terrestrial vertebrates. Diverging from other ray-finned fishes approximately 42...
Novel TLR2 agonist Amuc_C derived from Akkermansia muciniphila exhibits potent anti-tumor activity in colorectal cancers [0.03%]
源自Akkermansia muciniphila的新TLR2激动剂Amuc_C在结直肠癌中表现出强大的抗肿瘤活性
Liang Chi,Chiao-Hsu Ke,Hsin-Yi Wu et al.
Liang Chi et al.
Colorectal cancer (CRC) is a challenging disease. Recent studies have gradually emphasized the development of novel immunotherapies rather than traditional treatments. Toll-like receptor (TLR) agonists are critical in innate immune response...