Regulation of BAT thermogenesis via TRPA1-expressing hypothalamic POMC neurons [0.03%]
下丘脑POMC神经元通过TRPA1调节BAT产热作用
Arbi Bahtiar Boedi Iman Halanobis,Ju Hwan Yang,Eun-Hye Byeon et al.
Arbi Bahtiar Boedi Iman Halanobis et al.
Pro-opiomelanocortin (POMC) neurons in the hypothalamic arcuate nucleus (ARC) play a pivotal role in regulating brown adipose tissue (BAT) thermogenesis via the sympathetic nervous system. The activation of transient receptor potential anky...
Differential effects of nesfatin-1 on proliferation and migration in normal and cancerous human lung cells via the PI3K/AKT pathway [0.03%]
内源性抑癌肽nesfatin-1通过PI3K/AKT信号通路选择性抑制肺癌细胞增殖和迁移的作用及机制分析研究
Eunji Im,Jinah Ha,Jeongha Kim et al.
Eunji Im et al.
Nesfatin-1, initially identified as an appetite-regulating hormone, has also been detected in various cancer tissues and implicated in tumorigenesis. However, its role in the proliferation and migration of lung cancer cells remains unclear....
A comparative study of capacitation-mediated changes in whole mouse sperm proteome [0.03%]
capacitation介导的整个小鼠精子蛋白质组变化的比较研究
Jae Yeon Hwang
Jae Yeon Hwang
Mammalian spermatozoa acquire fertilizing ability in response to environmental factors enriched in the female reproductive tract, a process called capacitation. During capacitation, sperm undergo physiological changes that are accompanied b...
The RNA revolution in medicine: from gene regulation to clinical therapeutics [0.03%]
RNA革命在医学中的应用：从基因调控到临床治疗
Jiwon Jeong,Sunjoo Jeong
Jiwon Jeong
Breakthrough discoveries in RNA biology have led to a paradigm shift in our understanding of RNA-from passive intermediates to active regulators of gene expression. Technological innovations and deeper insights into RNA regulation have tran...
Xanthoxyline prevents aging and neuronal damage by activating autophagy and DAF-16 expression in Caenorhabditis elegans [0.03%]
通过在秀丽隐杆线虫中激活自噬和DAF-16表达来预防衰老和神经损伤的金色合剂成分弗斯可林的作用研究
Hyemin Kim,Saebyeol Lee,Hak Kyun Kim et al.
Hyemin Kim et al.
Xanthoxyline, a plant-derived phytochemical, has anti-bacterial, anti-fungal, and anti-cancer activities. We intended to investigate the effect of xanthoxyline on the response to oxidative stress, aging, and Parkinson's disease. The effects...
RNA binding protein HuD regulates fatty acid oxidation in pancreatic β-cells by modulating long-chain acyl-CoA dehydrogenase expression [0.03%]
RNA结合蛋白HuD通过调节长链酰基辅酶A脱氢酶的表达来调控胰岛β细胞的脂肪酸氧化反应
Jiyoon Seo,Seungyeon Ryu,Wei Zhang et al.
Jiyoon Seo et al.
RNA binding proteins (RBPs) play crucial roles in the post-transcriptional regulation of metabolic pathways. Although the RBP HuD has been extensively studied in pancreatic β-cells, its role in cellular metabolism remains poorly understood...
Targeting MMR-deficient colorectal cancer with a potent small molecule UNI110 [0.03%]
靶向MMR缺陷型结直肠癌的高效小分子UNI110
Enkhzul Amarsanaa,Jung-Min Oh,Seon Young Lee et al.
Enkhzul Amarsanaa et al.
Mismatch repair (MMR) deficiency is a hallmark of microsatellite instability (MSI) in hereditary non-polyposis colorectal cancer, Lynch syndrome, contributing to resistance against conventional chemotherapy and posing a significant therapeu...
Asxl1 regulates optic cup development through interaction with Lhx2 and epigenetic modulation of Wnt signaling [0.03%]
ASXL1通过与LHX2相互作用和表观遗传调控Wnt信号通路调节视杯发育
Seungtae Moon,Nackhyuong Kim,A-Reum Kim et al.
Seungtae Moon et al.
The additional sex combs-like 1 (Asxl1) gene is a chromatin regulator involved in transcriptional activation and repression. While Asxl1 plays a crucial role in various organ development, its role in ocular development remains unclear. Here...
Troponin I - a comprehensive review of its function, structure, evolution, and role in muscle diseases [0.03%]
肌钙蛋白I功能、结构、进化及在肌肉疾病中作用的全面综述
Dongju Han,Younghyun Lim,Soah Lee et al.
Dongju Han et al.
The troponin complex is a critical component of thin filaments and plays an essential role in the calcium-mediated regulation of contraction and relaxation in striated muscles, including both cardiac and skeletal muscle. Troponin I, a subun...
Zanthoxylum schinifolium extracts enhance 3T3-L1 adipocyte differentiation via CHOP inhibition and PPARγ activation [0.03%]
刺枣皮提取物通过抑制CHOP和激活PPARγ促进3T3-L1脂肪细胞分化
Jiseok Lee,Bo-Ram Kim,Kyeoungtae Park et al.
Jiseok Lee et al.
Zanthoxylum schinifolium (ZS), which is widely used as a seasoning and traditional medicine in East Asia, has demonstrated pharmacological potential. This study investigated the effects of the leaf and twig extracts of ZS (LZSE and TZSE, re...