Toxicity assessment using neural organoids: innovative approaches and challenges [0.03%]
使用神经类器官进行毒性评估：创新方法与挑战
Si-Hyung Park,Woong Sun
Si-Hyung Park
Assessment of toxicity and efficacy in the nervous system is essential to ensure the safety of compounds and the efficacy of neurotherapeutics. Recently, technologies using neural organoids to mimic the structural and functional properties ...
In vitro study of silver nanoparticles-induced embryotoxicity using a rat whole embryo culture model [0.03%]
银纳米颗粒使用大鼠整体胚胎培养模型对胚胎毒性的体外研究
Woong-Il Kim,So-Won Pak,Se-Jin Lee et al.
Woong-Il Kim et al.
Recently, our in vivo experiment showed that silver nanoparticles (AgNPs) did not cause developmental toxicity. However, the putative influences of direct exposure of AgNPs on the embryo-fetuses could not be elucidated because the embryo-fe...
Maternal smoking and its short- or long-term impact on offspring liver pathologies: a review of experimental and clinical studies [0.03%]
母亲吸烟及其对后代肝脏病理的短期或长期影响：实验和临床研究综述
Daram Yang,Yu Ji Kim,Jong-Won Kim
Daram Yang
This review investigates the correlation between prenatal tobacco exposure and the risk of liver diseases in offspring. By synthesizing data from clinical trials and animal studies, it provides a comprehensive overview of the potential mech...
Alleviating doxorubicin-induced reproductive toxicity: protective and androgenic effects of drone larvae on sperm morphology and hormonal balance [0.03%]
减轻多柔比星诱导的生殖毒性：雄蜂幼虫对精子形态和激素平衡的保护作用和雄性效应
Kağan Ağan,Salih Tunç Kaya,Aydan Fülden Ağan et al.
Kağan Ağan et al.
Male infertility and compromised sperm quality are common side effects of Doxorubicin (DOX), a widely used chemotherapy drug. Its detrimental impact on male reproductive cells underscores the urgent need for effective protective measures. L...
SRXN1 is a novel protective factor against methylmercury-induced apoptosis in C17.2 mouse neural stem cells [0.03%]
SRXN1是甲基汞诱导C17.2小鼠神经干细胞凋亡的新保护因子
Naoya Yamashita,Yukie Yokoyama,Ayano Kumagai et al.
Naoya Yamashita et al.
Methylmercury is an environmental pollutant that exhibits severe cerebral neurotoxicity and remains a worldwide problem. Motor and mental development disorders have been observed in children born to women who consumed relatively large amoun...
Cherry Ng,Maxine Kim,Yanti et al.
Cherry Ng et al.
Oxidative stress plays a crucial role in the pathogenesis of acute kidney injury (AKI), chronic kidney disease (CKD), and the AKI-to-CKD transition. This review examines the intricate relationship between oxidative stress and kidney pathoph...
Current hPSC-derived liver organoids for toxicity testing: Cytochrome P450 enzymes and drug metabolism [0.03%]
目前用于毒性测试的来源于hPSC的肝类器官：细胞色素P450酶和药物代谢
Hyemin Kim,Han-Jin Park
Hyemin Kim
Drug-induced hepatotoxicity is the leading cause of attrition of drug candidates and withdrawal of marketed drugs owing to safety concerns. In most hepatotoxicity cases, the parent drugs are metabolized by cytochrome P450 (CYP) enzymes, gen...
Imatinib mesylate promotes melanogenesis through the modulation of p38 and MITF in murine cells [0.03%]
伊马替尼通过调节p38和MITF促进小鼠细胞黑素生成
Natchanok Talapphet,Moon-Moo Kim
Natchanok Talapphet
Imatinib mesylate is a targeted anti-cancer drug with skin pigmentation as a side effect. The action mechanism of imatinib mesylate on melanogenesis remains unclear. The purpose of this study was to elucidate the mechanism of imatinib mesyl...
Miran Jang,Soo-Im Choi,Gun-Hee Kim
Miran Jang
The aim of this study was to investigate genotoxicity of fucoidan-rich Undaria pinnatifida sporophyll (FUPS) using a three-component test battery. Our sulfate analysis method showed that FUPS extract contained 14% fucoidan sulfate. The reve...
Single and repeated-dose toxicity studies by intravaginal administration of Lactobacillus plantarum ATG-K2 powder in female rats [0.03%]
植物乳杆菌ATG-K2粉剂单次及反复灌阴对雌性大鼠毒理学研究
Jae-Hyun Kang,Min-Soo Kang,Sun-Don Kim et al.
Jae-Hyun Kang et al.
Bacterial vaginosis (BV) is a microbial dysbiosis that shifts the paradigms of vaginal flora from lactobacilli to opportunistic pathogens. Globally, BV is treated with antibiotic therapy and recurrence rates are > 70% occurring within 6 mon...