Advancing hepatotoxicity assessment: current advances and future directions [0.03%]
肝毒性评估的发展：现有进展与未来方向
Yewon Kim,Hojin Kim,Yohan Kim
Yewon Kim
During drug development, it is crucial to ensure that a drug exhibits effective activity in its target cells and organs. However, regardless of its effectiveness, a drug cannot be administered to patients if it exhibits toxicity in vivo. Ba...
Picolinic acid, a tryptophan metabolite, triggers cellular senescence by targeting NOS/p38 MAPK/CK1α/MLKL signaling and metabolic exhaustion in red blood cells [0.03%]
吡哆酸通过靶向NOS/p38 MAPK/CK1α/MLKL信号通路和代谢衰竭触发红细胞衰老
Sumiah A Alghareeb,Jawaher Alsughayyir,Mohammad A Alfhili
Sumiah A Alghareeb
Anemia is among the most commonly reported adverse events of anticancer therapy. Picolinic acid (PA), an endogenous metabolite of tryptophan degradation in the kynurenine pathway, is a metal chelator with an anticancer activity. The objecti...
Cd stabilizes HIF-1α under normoxic conditions via lysine-63-linked ubiquitination and induces ER stress and cell proliferation [0.03%]
镉通过赖氨酸的六十三位点链接的泛素化稳定常态条件下HIF-1α并产生内质网压力及细胞增殖作用
Abderrahmen Chargui,Imen Hammami,Abeer Hashem et al.
Abderrahmen Chargui et al.
Cadmium, a carcinogenic and toxic substance released into the environment, has emerged as a potent activator of lysine-63 ubiquitination, and lysine-63 is a crucial regulator of signal transduction pathways. Although critical, very little i...
Regulatory frameworks for fragrance safety in cosmetics: a global overview [0.03%]
全球化妆品行业的香料安全监管框架概述
Priyanka Rana,Diksha Pathania,Prakriti Gaur et al.
Priyanka Rana et al.
Fragrances play a crucial role in cosmetic products, influencing consumer preferences and enriching sensory experiences. However, making sure these products are safe, especially concerning natural and synthetic fragrances, requires robust r...
Toxicity of diclofenac sodium salt after two weeks of daily intramuscular administration in cynomolgus monkeys [0.03%]
在食蟹猴中每日肌内给药2周后对钠盐双氯芬酸毒性的研究
Sieun Yoo,Jung-Ho Noh,Hong-Soo Lee et al.
Sieun Yoo et al.
Diclofenac sodium salt (DSS) has been extensively studied in pharmacological research to better understand its pain relief and inflammation-reducing properties. However, it is crucial to evaluate the safety profile of this non-steroidal ant...
Short-term health effects of tear agents chlorobenzylidenemalononitrile and oleoresin capsicum during the civil riots of Santiago de Chile in 2019-2020 [0.03%]
2019至2020年智利圣地亚哥市民起义期间催泪剂氯苯甲酰基丙二腈和辣椒素对健康的短期影响
Carlos Jara Bravo,José Antonio Cernuda Martínez,Pedro Arcos González
Carlos Jara Bravo
Chlorobenzylidenemalononitrile (CS) and Oleoresin Capsicum (OC) were tear gasses used as anti-riot control agents during social unrest riots in Chile (October 2019-March 2020). This study posed as a research question what were the short-ter...
Huonggiang Nguyen,Uijin Juang,Suhwan Gwon et al.
Huonggiang Nguyen et al.
Protein kinase B (PKB/AKT) is a very important member of the protein kinase family, playing significant roles in various crucial processes including insulin-signaling, cell survival, growth, and metabolism. The carboxyl-terminal modulator p...
Targeting IDH1 mutation-driven Nrf2 signaling to suppress malignant behavior in fibrosarcoma cells [0.03%]
靶向IDH1突变驱动的Nrf2信号以抑制纤维肉瘤细胞的恶性行为
Seoyeon Park,Kyung-Soo Chun,Do-Hee Kim
Seoyeon Park
Isocitrate dehydrogenase 1 (IDH1) mutations are prevalent in various cancers and have significant implications for tumor biology. It is known that cancer cells with IDH1 mutations, particularly R132C or R132H, exhibit decreased production o...
Sargassum horneri extract attenuates high-dose acetaminophen-induced hepatotoxicity by enhancing the antioxidant activity and inhibiting acetaminophen activation in the mouse liver [0.03%]
褐藻斑马鱼提取物通过增强抗氧化活性和抑制乙酰氨基酚活化来缓解高剂量乙酰氨基酚致小鼠肝毒性
Jiwon Hwang,Hyo Jin Kim,Yubin Song et al.
Jiwon Hwang et al.
Sargassum horneri is an edible brown seaweed used as traditional medicine in various East Asian countries, such as China and Korea. Its therapeutic effects, including antioxidant and anti-inflammatory activities, have been reported in anima...
Exploring the safety parameters of Athenaea velutina ethanolic extract: a step towards harnessing its medicinal potential [0.03%]
探索Athenaea velutina乙醇提取物的安全参数：迈向利用其药用潜力的一步
Jordana Luizi Dos Prazeres,Alisson Andrade Almeida,Renner Philipe Rodrigues Carvalho et al.
Jordana Luizi Dos Prazeres et al.
Athenaea velutina (Sendtn.) D'Arcy, a native plant of the Brazilian Atlantic Forest, has exhibited potential pharmacological effects due to the presence of withanolides with anti-cancer and anti-inflammatory activities. However, there is a ...