Exposure and health effects follow-up study of residents near a former smelter site [0.03%]
冶炼厂遗址附近居民的暴露及健康效应追踪调查研究
Young-Hun Kim,Da-Som Lee,Jung-Eum Lee et al.
Young-Hun Kim et al.
The Seo-Cheon Janghang Smelter in South Korea closed in 1989 owing to its contribution to environmental pollution. The emissions from the smelter likely affect various environmental media and also pose significant health risks to nearby res...
Validation study of spectrophotometric direct peptide reactivity assay (spectro-DPRA), a newly modified in chemico skin sensitization test method [0.03%]
化学法皮肤致敏检测新方法光度直接肽反应法（Spectro-DPRA）验证研究
Hye-Jeong Sin,Ji-Young Bae,Sun-A Cho et al.
Hye-Jeong Sin et al.
This study was conducted to evaluate the accuracy and reliability of the Spectro-DPRA, an enhanced method for the OECD TG 442C (direct peptide reactivity assay, DPRA), serving as an alternative to animal testing for skin sensitization. The ...
The systemic toxicity of intravitreally injected gold nanorods in mice: Effects of size, surface conjugation, and post-injection period [0.03%]
金纳米棒对眼球内注射的小鼠系统毒性的影响：尺寸、表面连接和注射后的时期的作用
Hafithe M AlGhosain,Jiarui Nie,Tao Liu et al.
Hafithe M AlGhosain et al.
Gold nanorods (AuNRs) are promising for remote neuronal activation via photothermal effects, but their systemic toxicity when delivered ocularly is unclear. We assessed the systemic safety of intravitreally injected AuNRs in mice over 32 da...
Repeated dose toxicity of 4-methylbenzophenone: hepatotoxic and nephrotoxic effects in female Sprague-Dawley rats [0.03%]
4-甲基苯并苯酮的重复给药毒性：对Sprague Dawley雌鼠肝肾毒性的影响
Darlene Mae D Ortiz,Ngoc Minh-Hong Hoang,Handule Lee et al.
Darlene Mae D Ortiz et al.
4-Methylbenzophenone (4-MBP), a derivative of benzophenone commonly utilized in consumer products, has elicited significant safety concerns due to its potential to migrate from food packaging materials and its structural similarity to known...
Systemic toxicity and toxicokinetics study of self-assembled-micelle inhibitory RNA-targeting amphiregulin in cynomolgus monkeys following intravenous injection [0.03%]
皮下注射自组装胶束化抑制AMF的靶向RNA后食蟹猴的整体毒性及毒代动力学研究
Hyeon-Young Kim,Tae-Rim Kim,Sung-Hwan Kim et al.
Hyeon-Young Kim et al.
Self-assembled-micelle inhibitory RNA-targeting amphiregulin (SAMiRNA-AREG) is a novel RNA interference-based nanoparticle for treating fibrotic diseases. The present non-clinical study investigated the potential 4-week repeated intravenous...
Current status and future prospects of toxicity assessment using organoids [0.03%]
类器官毒性评估研究进展与未来前景展望
Xuan-Hung Nguyen,Jongman Yoo
Xuan-Hung Nguyen
Organoids offer innovative platforms for toxicity assessment by more accurately recapitulating the structural and functional complexity of human tissues compared to traditional 2D cultures and animal models. This review summarizes current a...
Evaluation of radiation-induced bone marrow toxicity using artificial intelligence-based image analysis in mice [0.03%]
基于人工智能的图像分析评估辐射诱导骨髓毒性（小鼠模型）
Yoon Ji Choi,Da Song Back,Kwang Ho Jang et al.
Yoon Ji Choi et al.
Radiation exposure profoundly affects bone marrow, with even low-dose exposure inducing notable biological changes. Traditional pathology methods often face challenges in detecting subtle alterations. However, artificial intelligence (AI) o...
Sodium benzoate exposure from juvenile to peripubertal period disrupts HPG-axis in both male and female rats [0.03%]
苯甲酸钠在幼年和性成熟前期暴露会扰乱大鼠的下丘脑-垂体-性腺轴
Safdar Khan,Mohammad Attaullah,Sarwat Jahan et al.
Safdar Khan et al.
Sodium benzoate (SB) is a synthetic preservative that is widely used in the food and pharmaceutical industries. Despite its antibacterial and fungal static properties, it can impair reproduction. However, its toxicity has not been fully stu...
Anti-senescence and anti-apoptotic effects of immature Citrus unshiu peel ethanol extract on ultraviolet B-irradiated skin keratinocytes [0.03%]
柑橘不羞科未成热果皮乙醇提取物抗衰老及抗细胞凋零作用机制研究
Mei Jing Piao,Kyoung Ah Kang,Pincha Devage Sameera Madushan Fernando et al.
Mei Jing Piao et al.
Immature Citrus unshiu peel has garnered attention due to its potent antioxidant effects. In this study, we aimed to investigate the protective effects of immature citrus peel extract (ICPEE) against ultraviolet B (UVB) irradiation-induced ...
Honokiol induces paraptosis-like cell death through mitochondrial ROS-dependent endoplasmic reticulum stress in hepatocellular carcinoma Hep3B cells [0.03%]
肉桂酰亚胺通过线粒体ROS介导的内质网应激在肝癌Hep3B细胞中诱导类芽肿型细胞死亡
So Young Kim,Yung Hyun Choi
So Young Kim
Honokiol, a lignan found in Magnolia plant species, exerts diverse pharmacological effects, and induces apoptosis in several cancer cell lines, including human hepatocellular carcinoma (HCC). The present study aimed to investigate whether i...