Lysine-63-linked polyubiquitination: a principal target of cadmium carcinogenesis [0.03%]
赖氨酸63链聚泛素化是镉致癌的靶点
Abderrahmen Chargui
Abderrahmen Chargui
Cadmium is an environmental pollutant that constitutes a major danger to human health. It is considered a definite human carcinogen. The lung and kidney are the most sensitive organs for cancer development, and we recently provided the firs...
Erratum: Publisher Correction: Short-term inhalation exposure to cigarette smoke induces oxidative stress and inflammation in lungs without systemic oxidative stress in mice [0.03%]
勘误：出版更正：短期吸入香烟烟雾会在不引起全身氧化应激的情况下诱导小鼠肺部产生氧化应激和炎症反应
Yoon-Seok Seo,Kwang-Hoon Park,Jung-Min Park et al.
Yoon-Seok Seo et al.
[This corrects the article DOI: 10.1007/s43188-023-00223-y.]. © The Author(s) under exclusive licence to Korean Society of Toxicology 2024.
Published Erratum
Toxicological research. 2024 Apr 23;40(3):499. DOI:10.1007/s43188-024-00231-6 2024
Changmin Kim,Eunseo Jeong,Yoo-Bin Lee et al.
Changmin Kim et al.
Human cytochrome P450 (CYP) enzymes are composed of 57 individual enzymes that perform monooxygenase activities. They have diverse physiological roles in metabolizing xenobiotics and producing important endogenous compounds, such as steroid...
Updates on the mechanisms of toxicities associated with monoclonal antibodies targeting growth factor signaling and immune cells in cancer [0.03%]
针对癌症生长因子信号传导和免疫细胞的单克隆抗体相关毒性的机制更新
Miso Park,Ji Won Kim
Miso Park
Monoclonal antibody (mAb)-based immunotherapy currently is considered to be an optimal therapeutic approach to cancer treatment, either in combination with surgery, radiation, and/or chemotherapy or alone. Various solid tumors and hematolog...
Analytical method development and dermal absorption of gallic acid, a hair dye ingredient [0.03%]
棓酸的分析方法开发及透皮吸收研究（一种染发剂成分）
Yu Jin Kim,Hyang Yeon Kim,Jung Dae Lee et al.
Yu Jin Kim et al.
Gallic acid (GA) is a phenolic compound known as 3,4,5-trihydroxybenzoic acid. GA is used as a hair dye ingredient. It is limited to be below 4.0% in Korea. Dermal absorption rate of GA has not been reported yet. In this study, an analytica...
Regulatory role of Echinochrome A in cancer-associated fibroblast-mediated lung cancer cell migration [0.03%]
ECHINOCHROME A通过调控癌相关成纤维细胞的生物学功能抑制肺癌迁移侵袭中的领导细胞表型
Da-Young Eum,Chaeyoung Lee,Cong So Tran et al.
Da-Young Eum et al.
Echinochrome A (Ech A), a marine biosubstance isolated from sea urchins, is a strong antioxidant, and its clinical form, histochrome, is being used to treat several diseases, such as ophthalmic, cardiovascular, and metabolic diseases. Cance...
Elucidation of the effects of 2,5-hexandione as a metabolite of n-hexane on cognitive impairment in leptin-knockout mice (C57BL/6-Lepem1Shwl/Korl) [0.03%]
2,5-己anedione作为己烷的代谢物对leptin敲除小鼠（C57BL/6-Lepem1Shwl/Korl）认知损伤的影响研究
Hai Duc Nguyen,Won Hee Jo,Jae Ok Cha et al.
Hai Duc Nguyen et al.
Exposure to n-hexane and its metabolite 2,5-hexandione (HD) is a well-known cause of neurotoxicity, particularly in the peripheral nervous system. To date, few studies have focused on the neurotoxic effects of HD on cognitive impairment. Ex...
Yeonju Ko,Donghyeon Lim,Hyunjoon Choi et al.
Yeonju Ko et al.
Dodecamethylcyclohexasiloxane (D6) is a siloxane substance mainly used in cosmetics and personal care products. While octamethylcyclotetrasiloxane (D4) and decamethylcyclopentasiloxane (D5) were once commonly used in personal care products,...
DEHP (di(2-ethylhexyl)phthalate) stimulates skin pigmentation by perturbing cytoskeletal homeostasis [0.03%]
邻苯二甲酸二乙基己酯通过干扰细胞骨架稳态来促进皮肤色素沉着
Minjeong Kim,Kyung-Min Lim
Minjeong Kim
Phthalates are extensively employed plasticizers crucial for conferring flexibility and plasticity to polyvinyl chloride. Phthalates, including DEHP (di(2-ethylhexyl)phthalate), present in diverse products, have been identified in fine dust...
A convenient spectrophotometric test for screening skin-sensitizing chemicals using reactivity with glutathione in chemico [0.03%]
一种方便的分光光度法筛查皮肤致敏化学物质的检测方法，该方法采用化学中谷胱甘肽的反应性
Dong Ho Cha,Geon Ho Kim,Rahul U Nepal et al.
Dong Ho Cha et al.
To initiate skin sensitization, haptens react with endogenous proteins. During this process, skin sensitizers react with small endogenous molecules containing thiol or amino groups. In this study, a simple spectrophotometric method to ident...