Yuyoung Kim,You Hee Choi,Minji Kim et al.
Yuyoung Kim et al.
CRISPR-Cas12a proteins are RNA-guided endonucleases classified as type V-A effectors that function similarly to Cas9, but possess distinct biochemical features. Previous studies have reported that compared to Cas9, Cas12a exhibits reduced o...
Cannabidiol as a therapeutic agent for rosacea through simultaneous inhibition of multiple inflammatory pathways [0.03%]
大麻二酚通过同时抑制多种炎性通路治疗玫瑰痤疮
Chandani Shrestha,Eun Hee Yoo,Barsha Deshar et al.
Chandani Shrestha et al.
Rosacea is a chronic inflammatory skin disorder characterized by facial erythema, papules, pustules, and telangiectasia, affecting approximately 5.5% of the global population. Current treatments, primarily topical and oral antibiotics and a...
Ubiquitin specific protease 7 deubiquitinates and regulates Aurora B-mediated cytokinesis [0.03%]
泛素特异性蛋白酶7通过去泛素化调控Aurora B介导的有丝分裂后期-末期转换点的事件
Kamini Kaushal,Ainsley Mike Antao,Soumyadip Das et al.
Kamini Kaushal et al.
Aurora B is a widely studied mitotic checkpoint kinase that forms a part of the chromosomal passenger complex. The entry to and exit from mitosis are exquisitely controlled by Aurora B proteins, which regulate mitotic phases including chrom...
In vivo exosome imaging: applications of diverse visualization techniques [0.03%]
活体内细胞外囊泡成像：多样化的可视化技术及其应用
Seongje Hong,Hyun Chul Jo,Hye-Lin Kim et al.
Seongje Hong et al.
Exosomes-nanoscale extracellular vesicles secreted by various cell types-play a crucial role in intercellular communication by delivering biologically active molecules, such as proteins, nucleic acids, and lipids. Due to their intrinsic bio...
Hyeonji Song,Jaechul Lim
Hyeonji Song
Glucocorticoids (GCs) are steroid hormones that are commonly utilized in clinical practice due to their immunosuppressive properties. While GCs are commonly understood to diminish various aspects of the immune response, there is evidence su...
Contribution of histone deacetylases (HDACs) to the regulation of histone and non-histone proteins: implications for fibrotic diseases [0.03%]
组蛋白脱乙酰酶（HDAC）在组蛋白和非组蛋白调节中的作用：对纤维化疾病的启示
Sunyoung Jang,Nayun Choi,Jong Hoon Park et al.
Sunyoung Jang et al.
Histone deacetylases (HDACs) are essential enzymes that play a pivotal role in the epigenetic regulation of gene expression by catalyzing the removal of acetyl groups from histone and non-histone proteins. This deacetylation is a crucial po...
Decoding tau acetylation in Alzheimer's disease and tauopathies: from site-specific mechanisms to therapeutic horizons [0.03%]
阿尔茨海默病和tau蛋白病中Tau乙酰化的解码：从位点特异性机制到治疗前景
Yoonah R Oh,Min-Kyoo Shin
Yoonah R Oh
Tau acetylation has been recognized as a pivotal post-translational modification associated with the pathogenesis of Alzheimer's disease (AD) and other tauopathies. This review offers a detailed synthesis of the current understanding of sit...
Modulating CD226 and PD-(L)1 pathways improves CMV-specific CD8＋T cell responses in the absence of IL-2 [0.03%]
调节CD226和PD-(L)1途径可改善细胞因子IL-2缺失时的CMV特异性CD8⁺T细胞反应
Hye-In Sim,Yunju Jo,Hyejin Ahn et al.
Hye-In Sim et al.
Glioblastoma (GBM) frequently expresses cytomegalovirus (CMV) antigens, making CMV-specific CD8＋T cells attractive candidates for adoptive immunotherapy due to their longevity and inherent tumor reactivity. However, these T cells encounter s...
Diesel exhaust particles disrupt blood-retina barrier integrity via TLR2 and TLR4 activation [0.03%]
柴油颗粒物通过激活TLR2和TLR4扰乱血视网膜屏障的完整性的机制研究
Ji Young Kim,Eun Young Lee,Jin-Hee Kim et al.
Ji Young Kim et al.
Diesel exhaust particles (DEPs), a major component of air pollution, are well-known to induce inflammation and vascular dysfunction. However, the molecular mechanisms linking DEP exposure to the disruption of the blood-retina barrier (BRB) ...
Auranofin, an antirheumatic drug, shows anticancer stem cell potential via suppression of the Stat3 signal [0.03%]
治疗类风湿药物auranofin显示通过抑制Stat3信号压制癌症干细胞的潜力
Seung-Yeon Ko,Yuna Kim,Jin Sun Chung et al.
Seung-Yeon Ko et al.
Accumulating data have shown that targeting breast cancer stem cells (CSCs) is an auspicious way for anticancer therapies. This study demonstrated that the antirheumatic drug auranofin is a potent CSC inhibitor with anti-CSC action on breas...