Epigallocatechin gallate suppresses adipogenesis by targeting tetranectin and inhibiting its endocytosis via modulation of ERK and AKT signaling pathways [0.03%]
表没食子儿茶素没食子酸酯通过调节ERK和AKT信号通路靶向四nectrin并抑制其内吞作用来抑制脂肪细胞生成
Sana Iram,Jeongin Choi,Jihoe Kim
Sana Iram
Epigallocatechin gallate (EGCG), a major polyphenol in green tea, exhibits anti-obesity effects, but its precise mechanism remains to be fully elucidated. In this study, we found that EGCG suppresses the adipocyte differentiation of 3T3-L1 ...
Immunoproteasome inhibition protects the retina from Alzheimer's-associated degeneration [0.03%]
免疫蛋白酶体抑制保护视网膜免受阿尔茨海默病相关退行性病变的影响
Seobin Park,Yubin Lee,Minseo Kwak et al.
Seobin Park et al.
Alzheimer's disease (AD) is marked by progressive cognitive decline and retinal abnormalities, including degeneration of the retinal pigment epithelium (RPE). In models of AD, the accumulation of amyloid-β (Aβ) peptides triggers chronic i...
Urolithin A improves mitochondrial dysfunction induced by oxidative stress in human dermal papilla cells [0.03%]
氧化应激诱导的人乳头细胞线粒体功能损伤的防治研究——尿石素A通过核受体介导的转录调控网络发挥改善作用
Iksun Kwon,Seo-Eun Lee,Yujin Kim et al.
Iksun Kwon et al.
Hair loss is a psychologically debilitating condition affecting social interactions. Despite extensive research, current interventions are transient and provide limited efficacy. Emerging evidence highlights that oxidative stress, resulting...
Whole genome-based polygenic risk score and structural variation analysis in Korean patients with inflammatory bowel disease [0.03%]
基于整个基因组的多基因风险评分和结构变异在韩国炎症性肠病患者中的分析
Yu Kyung Jun,Jibin Jeong,Byoung Mok Kim et al.
Yu Kyung Jun et al.
The specific roles of single-nucleotide polymorphisms and structural variants (SVs) in Korean patients with inflammatory bowel disease (IBD) susceptibility remain unclear; hence this study aimed to evaluate polygenic risk scores (PRS) for I...
EK-16005, a 2-anilinopyrimidine derivative, inhibits breast cancer progression by regulating myeloid-derived suppressor cells [0.03%]
EK-16005通过调节髓源性抑制细胞来抑制乳腺癌的进展
Da-Young Eum,Cong So Tran,Jisu Kim et al.
Da-Young Eum et al.
Targeting the behavior of myeloid-derived suppressor cells (MDSCs), either by decreasing their population or inhibiting their immunosuppressive activity, has become a promising approach in breast cancer therapy. As pivotal mediators within ...
Immune phenotype-based stratification of colorectal cancer reveals subtype-specific immunotherapeutic opportunities: insights from a Korean patient cohort [0.03%]
基于免疫表型的结直肠癌分类发现了亚型特异性的免疫治疗机会——来自韩国患者队列的研究见解
Jinseon Yoo,Jinyong Kim,Hoang Bao Khanh Chu et al.
Jinseon Yoo et al.
Colorectal cancer (CRC) poses major clinical challenges, and deeper molecular and immunological insights are essential for precision oncology. We integrated RNA sequencing (RNA-seq) and clinical data from a Korean CRC cohort to profile tumo...
Prime editing updates: technological evolution, methodological expansion, and delivery strategies for in vivo applications [0.03%]
prime编辑更新：技术进化、方法扩展和体内应用的递送策略
Uijin Jong,Dongjae Lim,Seung Hwan Lee
Uijin Jong
Prime editing is a next-generation genome editing technology that enables precise base substitutions, insertions, and deletions at target genomic loci without inducing double-strand breaks or requiring exogenous donor DNA. This system opera...
Stigmasterol elicits antiviral activity against influenza viruses through virucidal and entry inhibition activity in vitro [0.03%]
牻牛儿醇通过在体外展示溶病毒和抑制病毒进入活性而产生对抗流感病毒的抗病毒作用
Ju Won Kim,Sanghyun Lee,Sejin Jeon et al.
Ju Won Kim et al.
Influenza viruses pose a significant global public health threat, leading to recurrent seasonal epidemics and occasional pandemics. The rising prevalence of drug-resistant strains highlights the urgent need for new antiviral agents with alt...
New approach methodologies to model liver fibrosis in metabolic dysfunction-associated steatohepatitis [0.03%]
代谢紊乱相关steatohepatitis肝纤维化模型的新方法学研究
Seung Min Lee,Da Kyung Hwang,Hyun Young Kim
Seung Min Lee
Metabolic dysfunction-associated steatohepatitis (MASH) is a significant global health issue and a leading cause of liver fibrosis, with no effective pharmacological treatments available. Conventional 2D cell cultures and animal models do n...
Review
BMB reports. 2026 Apr;59(4):219-226. DOI: 2026
Enzyme-assisted extraction of plant-derived extracellular vesicles: recent advances, methodological considerations, and standardization needs [0.03%]
酶辅助提取植物来源的细胞外囊泡：最新进展、方法学考量和标准化需求
Hyun Chul Jo,Seongje Hong,Kyung Oh Jung
Hyun Chul Jo
Plant-derived extracellular vesicles (PDEVs) have attracted increasing attention as bioactive nanostructures with emerging applications in medicine, functional foods, and cosmetics. However, unlike mammalian extracellular vesicle systems, t...