Galectin-3 Negatively Regulates miR-31 Processing in Breast Cancer Cells [0.03%]
乳癌细胞中Galectin-3通过抑制miR-31的成熟来发挥促肿瘤作用
Gi Soo Youn,Woo Young Lim,Yubin Kim et al.
Gi Soo Youn et al.
MicroRNA-31 (miR-31) acts as a tumor suppressor and is downregulated in breast cancer, but the mechanism responsible for its reduced maturation remains unclear. To investigate this, we examined the expression patterns of pri- and mature miR...
Tumor subtype-specific transcriptional signatures predict recurrence risk in hepatocellular carcinoma [0.03%]
肿瘤亚型特异性转录谱预测肝细胞癌复发风险
Hyeran Shim,Hoang Bao Khanh Chu,Jiun Kim et al.
Hyeran Shim et al.
Hepatocellular carcinoma (HCC) displays significant molecular heterogeneity that clinical staging alone does not fully account for when assessing the risk of recurrence following curative treatment. To address this, we developed a multi-coh...
T cell-based immunotherapy in solid tumors: mechanistic barriers and emerging opportunities [0.03%]
基于T细胞的免疫治疗在实体瘤中的机制障碍及新机遇
Hojin Chun,Hyunjin Ju,Sung-Min Hwang
Hojin Chun
T cell-based immunotherapies have transformed the treatment of hematological malignancies, but their efficacy in solid tumors remains inconsistent. Unlike blood cancers, solid tumors present multiple barriers that impede T cell infiltration...
GRP78/BiP as a novel midbody component induces mitotic exit failure via PLK1 stabilization in hepatocellular carcinoma [0.03%]
GRP78/BiP通过稳定PLK1诱导肝癌细胞有丝分裂退出失败并作为新型细胞中体成分
Sanghwa Kim,Yeonhwa Song,Su-Yeon Lee et al.
Sanghwa Kim et al.
Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related mortality worldwide and is associated with a poor prognosis, even when diagnosed in its early stages. Therefore, identifying novel HCC targets for therapeutic drug ...
Generation, Differentiation, and the Potential of Three Radial Glial Subtypes in Human Cortical Organoids [0.03%]
人脑类器官中三种放射状胶质细胞亚型的生成、分化及潜能研究
Mu Seog Choe,Jonghun Kim,In-Hyun Park
Mu Seog Choe
Radial glia are the principal neural stem cells in the developing human cerebral cortex and have been classified as three molecularly distinct subtypes: ventricular radial glia (vRG), outer radial glia (oRG), and truncated radial glia (tRG)...
Epigallocatechin gallate suppresses adipogenesis by targeting tetranectin and inhibiting its endocytosis via modulation of ERK and AKT signaling pathways [0.03%]
表没食子儿茶素没食子酸酯通过调节ERK和AKT信号通路靶向四nectrin并抑制其内吞作用来抑制脂肪细胞生成
Sana Iram,Jeongin Choi,Jihoe Kim
Sana Iram
Epigallocatechin gallate (EGCG), a major polyphenol in green tea, exhibits anti-obesity effects, but its precise mechanism remains to be fully elucidated. In this study, we found that EGCG suppresses the adipocyte differentiation of 3T3-L1 ...
Immunoproteasome inhibition protects the retina from Alzheimer's-associated degeneration [0.03%]
免疫蛋白酶体抑制保护视网膜免受阿尔茨海默病相关退行性病变的影响
Seobin Park,Yubin Lee,Minseo Kwak et al.
Seobin Park et al.
Alzheimer's disease (AD) is marked by progressive cognitive decline and retinal abnormalities, including degeneration of the retinal pigment epithelium (RPE). In models of AD, the accumulation of amyloid-β (Aβ) peptides triggers chronic i...
Urolithin A improves mitochondrial dysfunction induced by oxidative stress in human dermal papilla cells [0.03%]
氧化应激诱导的人乳头细胞线粒体功能损伤的防治研究——尿石素A通过核受体介导的转录调控网络发挥改善作用
Iksun Kwon,Seo-Eun Lee,Yujin Kim et al.
Iksun Kwon et al.
Hair loss is a psychologically debilitating condition affecting social interactions. Despite extensive research, current interventions are transient and provide limited efficacy. Emerging evidence highlights that oxidative stress, resulting...
Whole genome-based polygenic risk score and structural variation analysis in Korean patients with inflammatory bowel disease [0.03%]
基于整个基因组的多基因风险评分和结构变异在韩国炎症性肠病患者中的分析
Yu Kyung Jun,Jibin Jeong,Byoung Mok Kim et al.
Yu Kyung Jun et al.
The specific roles of single-nucleotide polymorphisms and structural variants (SVs) in Korean patients with inflammatory bowel disease (IBD) susceptibility remain unclear; hence this study aimed to evaluate polygenic risk scores (PRS) for I...
EK-16005, a 2-anilinopyrimidine derivative, inhibits breast cancer progression by regulating myeloid-derived suppressor cells [0.03%]
EK-16005通过调节髓源性抑制细胞来抑制乳腺癌的进展
Da-Young Eum,Cong So Tran,Jisu Kim et al.
Da-Young Eum et al.
Targeting the behavior of myeloid-derived suppressor cells (MDSCs), either by decreasing their population or inhibiting their immunosuppressive activity, has become a promising approach in breast cancer therapy. As pivotal mediators within ...