Redefining preclinical testing: human-relevant alternatives beyond animal models [0.03%]
重新定义非临床试验：超越动物模型的与人相关的替代方法
Jieun Jang,Wonjun Yang,Hanseul Yang et al.
Jieun Jang et al.
Both ethical imperatives and scientific limitations increasingly challenge the traditional reliance on animal models for toxicity testing and drug evaluation, particularly in the era of precision medicine. In response, a paradigm shift is u...
Toward unraveling molecular grammars for dsRNA-binding proteins: substrate recognition to binding mechanisms [0.03%]
解开dsRNA结合蛋白分子规则的面纱：从底物识别到结合机制
Jaemin Jeon,Yoosik Kim
Jaemin Jeon
Long double-stranded RNAs (dsRNAs) are recognized by innate immune response proteins, thereby initiating the integrated stress response. As these RNAs adopt an A-form helical structure, immune sensors recognize dsRNAs primarily based on the...
AQP1/4, CLIC5 Dysregulation and lipid metabolism alterations in lung cancer [0.03%]
肺腺癌中AQP1/4、CLIC5失调及脂质代谢异常
Heung-Seok Bae,Je-Yoel Cho
Heung-Seok Bae
To advance the development of novel therapies for lung cancer, we investigated tumor-associated molecules implicated in tumorigenesis. RNA-seq data were generated from paired tumors and adjacent normal tissues of four patients with lung squ...
Lefty2 prevents RANKL-induced bone loss by inhibiting osteoclast differentiation [0.03%]
左旋糖酐硫酸钠通过抑制破骨细胞分化来预防RANKL诱导的骨质流失
Jung Ha Kim,Kabsun Kim,Inyoung Kim et al.
Jung Ha Kim et al.
Left-right determination factor 2 (Lefty2) is a transforming growth factor-β (TGF-β) receptor ligand that is critical for organ asymmetry and cell proliferation. More broadly, the TGF-β superfamily plays indispensable roles in developmen...
Chang Beom Jeong,Hyein Cho,Daechan Park
Chang Beom Jeong
Modern genomic sequencing techniques have advanced rapidly, thereby improving data production rates and dimensionality. With this accelerated growth, machine learning, especially deep learning, has been leveraged to analyze complex data and...
Systems memory consolidation during sleep: oscillations, neuromodulators, and synaptic remodeling [0.03%]
睡眠中的系统巩固：振荡、神经调质和突触改造
Jaekyung Kim,Minjeong Park
Jaekyung Kim
Memory consolidation transforms newly acquired experiences into stable long-term memories essential for learning and cognition. This process involves systems consolidation, where memory traces are reorganized across brain regions, and synap...
APC/C-CDH1 suppresses AROS-mediated protection against DNA damage-induced senescence by ubiquitination [0.03%]
APC/C-CDH1通过泛素化抑制AROS介导的DNA损伤诱导衰老保护作用
Ji-Hye Yang,Hanbyeul Choi,Seung Baek Lee et al.
Ji-Hye Yang et al.
Anaphase-promoting complex/cyclosome (APC/C) regulates the cell cycle by destruction of target proteins ubiquitination. However, understanding the control of APC/C has remained elusive. We identify APC2, the catalytic core subunit of APC/C,...
Functional analysis of secreted tissue inhibitor of metalloproteinases-1 from adult human neural stem cells (ahNSCs) for regeneration and neuroprotection [0.03%]
人源神经干细胞分泌的组织金属蛋白酶抑制剂-1的功能分析及其在再生和神经保护中的作用
Ki Hoon Kim,Dong Geun Hong,Hye Yun Chae et al.
Ki Hoon Kim et al.
The adult human neural stem cell (ahNSC)-conditioned medium (CM) contains various secreted factors that promote tissue repair and neuroprotection. This study aimed to identify the key secreted proteins in ahNSC-CM and investigate the role o...
N-acetyl-L-alanine ameliorates atopic dermatitis-like symptoms by suppressing Th2 differentiation in DNFB-induced NC/Nga mice [0.03%]
N-乙酰-L-谷氨酰胺通过抑制DNFB诱导的NC/Nga小鼠中T辅助细胞2分化来改善特应性皮炎症状
Uyanga TSogt,Seung-Gook Kim,Suhong Duan et al.
Uyanga TSogt et al.
Atopic dermatitis (AD) is a chronic dermatological disorder characterized by intense pruritus and eczematous lesions. Repeated topical application of 2,4-dinitrofluorobenzene (DNFB) in NC/Nga mice produces AD-like clinical symptoms that clo...
Cereblon upregulation overcomes thalidomide resistance in multiple myeloma through mitochondrial functional reprogramming [0.03%]
cereblon上调通过线粒体功能重构克服多发性骨髓瘤中的沙利度胺耐药性
Jubert Marquez,Nammi Park,Jae Hyeog Choi et al.
Jubert Marquez et al.
Patients with multiple myeloma develop resistance to thalidomide during therapy, and the mechanisms to counteract thalidomide resistance remain elusive. Here, we explored the interaction between cereblon and mitochondrial function to mitiga...