CodonMutator: A Python-based Automated Oligonucleotide Design Framework for Deep Mutational Scanning Library Construction [0.03%]
CodonMutator：一种基于Python的自动化寡核苷酸设计框架用于构建深度突变扫描文库
Jeongha Lee,Seong Kyoon Park,Byung Joon Hwang et al.
Jeongha Lee et al.
Deep mutational scanning (DMS) enables systematic evaluation of protein sequence-function relationships, but its utility is often limited by the complexity of library construction. Existing mutagenesis strategies are either biased, labor-in...
Min Yong Lee,Hyo Won Kim,Kwang Lee
Min Yong Lee
Most in vivo neural technologies have been developed to either enhance the resolution for capturing subcellular neuronal activity or to expand the spatial range for tracking the populational ensemble of neurons in the brains of live animals...
Multi-layered gene regulation by long non-coding RNAs: from chromatin to genome architecture [0.03%]
长非编码RNA的多层基因调控作用：从染色质到基因组结构
Jaeryoung Kyung,Minjae Kim,Hye-Rim Shin et al.
Jaeryoung Kyung et al.
Long non-coding RNAs (lncRNAs) are now recognized as being pivotal regulators that enable the fine-tuned control of gene expression. While the functional diversity of lncRNAs challenges comprehensive understanding of their mechanisms, recen...
Precision Geronutrition: Personalized Nutritional Strategies to Extend Healthy Lifespan [0.03%]
精准营养学：延长健康寿命的个性化营养策略
So-Hyun Park,Chang Hwa Jung,Jiyun Ahn
So-Hyun Park
Aging is a multifactorial and heterogeneous biological process, where chronological age alone does not accurately reflect an individual's functional or physiological state. The emerging discipline of precision geronutrition integrates the p...
Imperfect Repair in Aging: Senescent Cells and the Hepatic Fibrotic Niche [0.03%]
老化过程中的修复缺陷：衰老细胞与肝纤维化微环境
Juyeon Kim,Minseong Kim,Chuna Kim
Juyeon Kim
Aging proceeds in a nonuniform spatiotemporal manner across tissues. While metabolic stress and chronic inflammation are implicated, the underlying mechanisms remain elusive. Here, we propose that imperfect wound healing-a failure of full r...
WenTing Gao,Hye-Yeon Lee,Kyung-Jin Min
WenTing Gao
The gut microbiota plays a fundamental role in maintaining host homeostasis, and the aging process profoundly influences its composition and function. Accumulating evidence suggests that alterations in the gut microbiota are not just a cons...
Dhx36 deficiency accelerates BMSC senescence and promotes age-related bone loss [0.03%]
DHX36缺乏加速骨髓间充质干细胞衰老并促进年龄相关性骨丢失
Ji Sun Jang,Suhan Jung,Min-Kyoung Song et al.
Ji Sun Jang et al.
Senescence of mesenchymal stem cells in bone tissue (BMSCs), the primary progenitors of osteoblasts, is a key contributor to age-related osteopenia and osteoporosis. Aged cells exhibit elevated cellular stress and abnormal accumulation of s...
Mitochondrial transfer from human embryonic stem cell-derived mature cardiomyocytes to mesenchymal stem cells [0.03%]
人胚胎干细胞源性成熟心肌细胞线粒体向间充质干细胞的转移
Ye Seul Jeong,Dasol Kim,Yoon Ji Jung et al.
Ye Seul Jeong et al.
Mitochondria are crucial for energy metabolism and their dysfunction is implicated in the development of various human diseases. Direct mitochondrial transplantation has shown potential in reversing mitochondrial dysfunction in recipient ce...
Stem cell factor regulates endothelial HIF-2α expression during hypoxia-driven pathological angiogenesis [0.03%]
干细胞因子在低氧驱动的病理性血管生成过程中调节内皮细胞HIF-2α表达
Hayoung Jeong,Yang Hee Choi,Yubin Hwang et al.
Hayoung Jeong et al.
Hypoxia-inducible factors (HIFs) act as master regulators of hypoxia-induced pathological angiogenesis, a hallmark of various ischemic ocular diseases. Recent evidence highlights the pivotal role of HIF-2α among HIF isoforms in endothelial...
Alpha-lipoic acid pretreatment attenuates TNF-α-triggered auditory hair cell damage via Nrf2 signaling-mediated antioxidant activity [0.03%]
α-硫辛酸的预处理通过Nrf2信号介导的抗氧化作用缓解TNF-α触发的听觉毛细胞损伤
Junyeong Yi,Myungjoo Shim,Jhang Ho Pak et al.
Junyeong Yi et al.
Excessive generation of reactive oxygen species (ROS) and proinflammatory cytokines is a pivotal mechanism causing sensorineural hearing loss (SNHL) through damage to auditory hair cells. In particular, high expression levels of tumor necro...