FOXO6 activation promotes hepatic steatosis via PPARα inhibition in aged male rats [0.03%]
FOXO6活化通过抑制PPARα诱导雄性老年大鼠肝脂肪变性
Yeong Un Kim,Ji Hyun Park,Dae Hyun Kim
Yeong Un Kim
Aging contributes to hepatic steatosis by increasing de novo lipogenesis. The Forkhead box O6 (FOXO6) transcription factor links insulin signaling to lipid metabolism. Activated FOXO6 induces hyperlipidemia and decreases peroxisome prolifer...
CaMKIV negatively regulates osteoblast differentiation by modulating c-Fos and NFATc1 signaling: an in vitro and in vivo mechanistic study [0.03%]
钙调神经磷酸酶依赖的CREB激酶IV通过调节c-Fos和NFATc1信号负向调控成骨细胞分化：体内体外机制研究
Jung Ha Kim,Kabsun Kim,Inyoung Kim et al.
Jung Ha Kim et al.
The CaMKIV-c-Fos-NFATc1 axis is established in osteoclastogenesis, but its role in osteoblasts is largely unexplored. We show that this axis suppresses osteoblast differentiation and bone formation. Silencing CaMKIV increased osteogenic gen...
Cell-penetrating H3 tail peptides suppress osteoclast differentiation via inhibition of MMP-9-mediated histone H3 clipping [0.03%]
细胞穿透的H3尾肽通过抑制MMP-9介导的组蛋白H3切割来抑制破骨细胞分化
Seokchan Lee,Jisu Lee,Sun-Ju Yi et al.
Seokchan Lee et al.
Osteoclast-mediated bone resorption is closely linked to bone formation, and any disruption in this process can lead to diseases such as osteoporosis. Matrix metalloproteinase-9 (MMP-9) is a nuclear histone protease that specifically cleave...
MT1B overexpression enhances malignancy of A549 non-small cell lung cancer cells [0.03%]
MT1B过表达增强A549非小细胞肺癌细胞恶性表型
Yoon Hee Park,Hong Lee,Haewon Kim et al.
Yoon Hee Park et al.
Metallothioneins (MTs) are metal-binding proteins that are involved in heavy metal homeostasis and protection against oxidative stress. The MT1 family comprises several isoforms that are implicated in various diseases, including cancer. Alt...
Stress Granules as a Central Hub Linking Organelle Stress, Aging, and Neurodegeneration [0.03%]
应力颗粒作为连接细胞器应激、衰老和神经退行性疾病的中心节点
Hyun-Ji Ham,Jin-A Lee
Hyun-Ji Ham
Stress granules (SGs) are dynamic cytoplasmic assemblies composed of RNAs and proteins that form in response to cellular stress, serving to halt translation and protect cellular integrity. In neurons, SGs mediate adaptive, pro-survival resp...
Epigenetic aging and rejuvenation of the brain: drivers, consequences, and interventions [0.03%]
表观遗传学衰老和大脑年轻化：驱动因素、后果及应对措施
Seunghyun Lee,SeungA Cho,Seung-Kyoon Kim et al.
Seunghyun Lee et al.
Evolution has tuned epigenetic resilience to preserve chromatin organization, transcriptional networks, and cellular identity under relentless stress. Over time, however, all eukaryotic life faces an inevitable rise in entropy that erodes t...
Genetic architecture of human aging and longevity: Insights from genome-wide association studies [0.03%]
人类衰老和长寿的遗传结构：来自全基因组关联研究的启示
Dabin Yoon,Jungsoo Gim
Dabin Yoon
Aging represents a fundamental evolutionary feature shared across all living organisms, intrinsically coupled with development and lifespan. It is orchestrated by a complex polygenic architecture involving numerous small-effect variants dis...
Integrating Perspectives on Aging: From Mechanistic Causes to Therapeutic Interventions [0.03%]
整合衰老研究的视角：从机制原因到干预措施
Eun-Soo Kwon
Eun-Soo Kwon
Aging poses one of the most urgent biomedical challenges of the 21st century, increasing vulnerability to chronic diseases and limiting healthspan in aging populations. Recent advances in aging research are transforming our understanding of...
Multi-omics identification of a microbial metabolite driving OXPHOS-mediated epithelial damage in experimental autoimmune encephalomyelitis [0.03%]
多组学识别出一种微生物代谢物可驱动实验性自身免疫性脑脊髓炎中线粒体氧化磷酸化介导的上皮损伤
Eunike Tiffany,Panida Sittipo,Chanyoung Lee et al.
Eunike Tiffany et al.
Bowel syndrome is a prevalent and debilitating symptom in patients with multiple sclerosis (MS), substantially impairing their quality of life. However, the underlying mechanisms of MS development remain poorly understood. In this study, we...
Corin inhibits microglial inflammatory activation by suppressing mitochondrial dysfunction in intracerebral hemorrhage [0.03%]
corin通过抑制脑出血后的小胶质细胞线粒体功能障碍而发挥抗炎效应
Rui Yin,Caixia Qiu,Qikai Shen et al.
Rui Yin et al.
Microglial activation driving neuroinflammation is a key factor in secondary brain injury after intracerebral hemorrhage (ICH); however, the regulatory mechanisms remain unknown. This study investigates how corin influences microglial infla...