Anti-inflammatory action of ethanolic extract of Ramulus mori on the BLT2-linked cascade [0.03%]
Ramulus mori乙醇提取物的抗炎作用及对BLT2信号通路的影响
Geun-Soo Park,Jeong-Keun Kim,Jae-Hong Kim
Geun-Soo Park
Mulberry tree twigs (Ramulus mori) contain large amounts of oxyresveratrols and have traditionally been used as herbal medicines because of their anti-inflammatory properties. However, the signaling mechanism by which R. mori exerts its ant...
Targeted disruption of EBNA1 in EBV-infected cells attenuated cell growth [0.03%]
靶向破坏感染EB病毒细胞中的EBNA1减弱了细胞生长
Ka-Won Noh,Jihyun Park,Myung-Soo Kang
Ka-Won Noh
Epstein Barr virus (EBV)-encoded nuclear antigen-1 (EBNA1) plays a pivotal in an EBV episome replication and persistence. Despite considerable attempts, there are no EBV drugs or vaccines. We attempted to eradicate EBV episomes by targeting...
c-Jun N-terminal Kinase (JNK) induces phosphorylation of amyloid precursor protein (APP) at Thr668, in okadaic acid-induced neurodegeneration [0.03%]
D-环孢氨酸诱导的神经退行性疾病中活化的c-Jun氨基末端激酶(JNK)在Thr668位点对淀粉样前体蛋白(APP)磷酸化作用的影响
Ji-Hwan Ahn,Sang-Pil So,Na-Young Kim et al.
Ji-Hwan Ahn et al.
Several lines of evidence have revealed that phosphorylation of amyloid precursor protein (APP) at Thr668 is involved in the pathogenesis of Alzheimer's disease (AD). Okadaic acid (OA), a protein phosphatase-2A inhibitor, has been used in A...
Rationally designed siRNAs without miRNA-like off-target repression [0.03%]
不含微小核糖核酸(off-target)抑制作用的合理设计的小干扰核糖核酸
Heeyoung Seok,Eun-Sook Jang,Sung Wook Chi
Heeyoung Seok
Small interfering RNAs (siRNAs) have been developed to intentionally repress a specific gene expression by directing RNA-induced silencing complex (RISC), mimicking the endogenous gene silencer, microRNAs (miRNAs). Although siRNA is designe...
Crotamine stimulates phagocytic activity by inducing nitric oxide and TNF-α via p38 and NFκ-B signaling in RAW 264.7 macrophages [0.03%]
克罗塔明通过p38和NFкB信号途径诱导一氧化氮和TNF-α刺激RAW 264.7巨噬细胞的吞噬活性
Kyung Jin Lee,Yun Kyu Kim,Martin Krupa et al.
Kyung Jin Lee et al.
Crotamine is a peptide toxin found in the venom of the rattlesnake Crotalus durissus terrificus and has antiproliferative, antimicrobial, and antifungal activities. Herein, we show that crotamine dose-dependently induced macrophage phagocyt...
Induction of MAP kinase phosphatase 3 through Erk/MAP kinase activation in three oncogenic Ras (H-, K- and N-Ras)-expressing NIH/3T3 mouse embryonic fibroblast cell lines [0.03%]
三种致癌RAS(H-,K-和N-RAS)表达的NIH/3T3小鼠胚胎成纤维细胞系中通过Erk/MAP激酶活化诱导MAP激酶磷酸酶3的生成
JaeHyung Koo,Sen Wang,NaNa Kang et al.
JaeHyung Koo et al.
Ras oncoproteins are small molecular weight GTPases known for their involvement in oncogenesis, which operate in a complex signaling network with multiple effectors. Approximately 25% of human tumors possess mutations in a member of this fa...
Chang Sup Lee,Jaewang Ghim,Parkyong Song et al.
Chang Sup Lee et al.
Vascular endothelial growth factor (VEGF) is a key mediator of angiogenesis and critical for normal embryonic development and repair of pathophysiological conditions in adults. Although phospholipase D (PLD) activity has been implicated in ...
Jae Seok Lim,Jeong Ho Lee
Jae Seok Lim
Focal cortical dysplasia type II (FCDII) is a focal malformation of the developing cerebral cortex and the major cause of intractable epilepsy. However, since the molecular genetic etiology of FCD has remained enigmatic, the effective thera...
Hyoung-Tai Kim,Alain Prochiantz,Jin Woo Kim
Hyoung-Tai Kim
Mutations of orthodentricle homeobox 2 (OTX2) in human and mice often cause retinal dystrophy and nyctalopia, suggesting a role of OTX2 in mature retina, in addition to its functions in the development of the eye and retina. In support of t...
Regulation of amyloid precursor protein processing by its KFERQ motif [0.03%]
其KFERQ基序调节淀粉样前体蛋白加工成熟机制研究
Ji-Seon Park,Dong-Hou Kim,Seung-Yong Yoon
Ji-Seon Park
Understanding of trafficking, processing, and degradation mechanisms of amyloid precursor protein (APP) is important because APP can be processed to produce β-amyloid (Aβ), a key pathogenic molecule in Alzheimer's disease (AD). Here, we f...