Structural and dynamic views of the CRISPR-Cas system at the single-molecule level [0.03%]
单分子视角下的CRISPR-Cas系统结构和动态过程
Seung Hwan Lee,Sangsu Bae
Seung Hwan Lee
The CRISPR-Cas system has emerged as a fascinating and important genome editing tool. It is now widely used in biology, biotechnology, and biomedical research in both academic and industrial settings. To improve the specificity and efficien...
MicroRNA-orchestrated pathophysiologic control in gut homeostasis and inflammation [0.03%]
肠道稳态和炎症中的微RNA介导的生理病理调控
Juneyoung Lee,Eun Jeong Park,Hiroshi Kiyono
Juneyoung Lee
The intestine represents the largest and most elaborate immune system organ, in which dynamic and reciprocal interplay among numerous immune and epithelial cells, commensal microbiota, and external antigens contributes to establishing both ...
Jaehong Kim
Jaehong Kim
The disease known as cerebral cavernous malformations mostly occurs in the central nervous system, and their typical histological presentations are multiple lumen formation and vascular leakage at the brain capillary level, resulting in dis...
Erratum: Role of vascular smooth muscle cell in the inflammation of atherosclerosis [0.03%]
动脉粥样硬化炎症中血管平滑肌细胞作用的再探讨的更正原文发表日期:2013年4月1日
Soyeon Lim,Sungha Park
Soyeon Lim
Published Erratum
BMB reports. 2016 Feb;49(2):134. DOI: 2016
Biphasic activation of extracellular signal-regulated kinase (ERK) 1/2 in epidermal growth factor (EGF)-stimulated SW480 colorectal cancer cells [0.03%]
表皮生长因子(EGF)激活SW480结肠直肠癌细胞后细胞外信号调节激酶(ERK)1/2的双相活化现象
Donghyun Joo,Jong Soo Woo,Kwang-Hyun Cho et al.
Donghyun Joo et al.
Cancer cells have different characteristics due to the genetic differences where these unique features may strongly influence the effectiveness of therapeutic interventions. Here, we show that the spontaneous reactivation of extracellular s...
Anti-inflammatory action of ethanolic extract of Ramulus mori on the BLT2-linked cascade [0.03%]
Ramulus mori乙醇提取物的抗炎作用及对BLT2信号通路的影响
Geun-Soo Park,Jeong-Keun Kim,Jae-Hong Kim
Geun-Soo Park
Mulberry tree twigs (Ramulus mori) contain large amounts of oxyresveratrols and have traditionally been used as herbal medicines because of their anti-inflammatory properties. However, the signaling mechanism by which R. mori exerts its ant...
Targeted disruption of EBNA1 in EBV-infected cells attenuated cell growth [0.03%]
靶向破坏感染EB病毒细胞中的EBNA1减弱了细胞生长
Ka-Won Noh,Jihyun Park,Myung-Soo Kang
Ka-Won Noh
Epstein Barr virus (EBV)-encoded nuclear antigen-1 (EBNA1) plays a pivotal in an EBV episome replication and persistence. Despite considerable attempts, there are no EBV drugs or vaccines. We attempted to eradicate EBV episomes by targeting...
c-Jun N-terminal Kinase (JNK) induces phosphorylation of amyloid precursor protein (APP) at Thr668, in okadaic acid-induced neurodegeneration [0.03%]
D-环孢氨酸诱导的神经退行性疾病中活化的c-Jun氨基末端激酶(JNK)在Thr668位点对淀粉样前体蛋白(APP)磷酸化作用的影响
Ji-Hwan Ahn,Sang-Pil So,Na-Young Kim et al.
Ji-Hwan Ahn et al.
Several lines of evidence have revealed that phosphorylation of amyloid precursor protein (APP) at Thr668 is involved in the pathogenesis of Alzheimer's disease (AD). Okadaic acid (OA), a protein phosphatase-2A inhibitor, has been used in A...
Rationally designed siRNAs without miRNA-like off-target repression [0.03%]
不含微小核糖核酸(off-target)抑制作用的合理设计的小干扰核糖核酸
Heeyoung Seok,Eun-Sook Jang,Sung Wook Chi
Heeyoung Seok
Small interfering RNAs (siRNAs) have been developed to intentionally repress a specific gene expression by directing RNA-induced silencing complex (RISC), mimicking the endogenous gene silencer, microRNAs (miRNAs). Although siRNA is designe...
Crotamine stimulates phagocytic activity by inducing nitric oxide and TNF-α via p38 and NFκ-B signaling in RAW 264.7 macrophages [0.03%]
克罗塔明通过p38和NFкB信号途径诱导一氧化氮和TNF-α刺激RAW 264.7巨噬细胞的吞噬活性
Kyung Jin Lee,Yun Kyu Kim,Martin Krupa et al.
Kyung Jin Lee et al.
Crotamine is a peptide toxin found in the venom of the rattlesnake Crotalus durissus terrificus and has antiproliferative, antimicrobial, and antifungal activities. Herein, we show that crotamine dose-dependently induced macrophage phagocyt...