LPS stimulation-induced regulation of LECT2 expression via TLR4 in hepatocytes [0.03%]
TLR4介导的LPS刺激诱导肝细胞LECT2表达调控作用机制研究
Ayoub El Bakiallah,Desy Simamora Damayanti,Rosana Nogueira et al.
Ayoub El Bakiallah et al.
Leukocyte cell-derived chemotaxin 2 (LECT2), a secreted protein, is implicated in various physiological and pathological processes. As a hepatokine, LECT2 is predominantly synthesized and secreted by hepatocytes, with elevated levels being ...
High-resolution detection of RPS24 microexon variations reveals novel splicing patterns in response to KRAS-targeted therapy in lung adenocarcinoma [0.03%]
高分辨率检测RPS24微外显子变异，揭示了肺腺癌对KRAS靶向治疗的新型剪接模式
Dahye Nam,Bin Tian,Jiyeon Park et al.
Dahye Nam et al.
Alternative splicing (AS) dysregulation is increasingly recognized as a critical factor in cancer progression and drug response. However, precisely detecting and characterizing complex splicing events, particularly those involving microexon...
Tat-GSTpi suppresses inflammatory responses by regulating ROS/MAPKs/apoptosis signaling pathways [0.03%]
Tat-GSTpi通过调节ROS/MAPKs/凋亡信号通路抑制炎症反应
Eun Ji Yeo,Min Jea Shin,Gi Soo Youn et al.
Eun Ji Yeo et al.
Glutathione S-transferase pi (GSTpi) is a phase II detoxifying enzyme that plays key roles in cellular processes. In a previous study, we have reported that cell permeable Tat-GSTpi can protect dopaminergic neurons against cell death. Howev...
Promiscuous enzyme SQOR in cellular metabolism and ferroptosis regulation [0.03%]
多功能酶SQOR在细胞代谢和铁死亡调控中的作用
Jumi Lee,Inhwan Yoo,Ihyeon Ahn et al.
Jumi Lee et al.
Ferroptosis, an iron-dependent form of programmed cell death, is primarily driven by the accumulation of lipid peroxides through radical generation, notably via the Fenton reaction. Emerging evidence highlights the intricate link between fe...
Erratum to: Celecoxib is the only nonsteroidal anti-inflammatory drug to inhibit bone progression in spondyloarthritis [0.03%]
Correction to: 集中式受理案件的法院是否更有效率？——基于最高人民法院申诉信访数据的分析
Jin Sun Choi,Ji-Young Kim,Min-Joo Ahn et al.
Jin Sun Choi et al.
[Erratum to: BMB Reports 2025; 58(3): 140-145, PMID: 39757202, PMCID: PMC11955732] The BMB Reports would like to issue a correction to an article published in BMB Rep. 58(3): 140-145, titled "Celecoxib is the only nonsteroidal anti-inflamma...
Published Erratum
BMB reports. 2025 Apr;58(4):190. DOI: 2025
MBNL2 enhances cisplatin resistance by regulating apoptosis in ovarian cancer cells [0.03%]
MBNL2通过调节卵巢癌细胞凋亡增强顺铂耐药性
Hye Youn Sung,Jihye Han,Woong Ju et al.
Hye Youn Sung et al.
Although cisplatin is an effective anticancer agent for treating ovarian cancer, it encounters significant resistance. A full understanding of the mechanisms behind cisplatin resistance has not been achieved. This study identifies MBNL2 as ...
VCAM1-mediated regulation of dopaminergic neuron function in Parkinson's disease [0.03%]
血管细胞粘附分子1介导的帕金森病多巴胺能神经元功能调节
Mihee Oh,Sunha Lee,Eunhye Kim et al.
Mihee Oh et al.
Parkinson's disease (PD) is the second most common neurodegenerative disorder, characterized by the degeneration of dopaminergic neurons, striatal dopamine deficiency, and the accumulation of intracellular α-synuclein aggregates. In this s...
Potential use of human pluripotency-related gene expression reporter cell line for screening small molecules to enhance induction of pluripotency [0.03%]
利用与人多能性相关的基因表达报告细胞系筛选增强诱导多能性的小分子药物
Seokbeom Ham,Minseong Lee,Dahee Jeong et al.
Seokbeom Ham et al.
The reprogramming of somatic cells into induced pluripotent stem cells (iPSCs) is a crucial development in regenerative medicine, providing patient-specific cells for therapeutic uses. Traditional methods often utilize viral vectors and tra...
Tissue-specific lncRNA GATA6-AS1 and its ortholog Moshe as essential regulators of aortic valve development [0.03%]
特异性组织长链非编码RNA GATA6-AS1及其同源基因Moshe是主动脉瓣发育的重要调控因子
Na-Jung Kim,Eun-Hye Moon,Ji Hoon Oh et al.
Na-Jung Kim et al.
Long noncoding RNAs (lncRNAs) are integral to epigenetic regulation during cardiogenesis; however, their role in aortic valve disease is not well characterized. Investigating lncRNAs present in the human embryonic heart and pinpointing thei...
Immune tolerance to foreign antigens in the intestine: mechanisms mediated by CD4＋ T cells [0.03%]
肠道对外来抗原的免疫耐受：CD4⁺T细胞介导的机制
Eunbi Yoo,Yeleen Jo,Jooyoun Park et al.
Eunbi Yoo et al.
The immune system encounters a diverse array of antigens, both self and foreign, necessitating mechanisms to maintain tolerance and prevent harmful inflammatory responses. CD4＋ T cells, crucial in orchestrating immune responses, play a criti...