MBNL2 enhances cisplatin resistance by regulating apoptosis in ovarian cancer cells [0.03%]
MBNL2通过调节卵巢癌细胞凋亡增强顺铂耐药性
Hye Youn Sung,Jihye Han,Woong Ju et al.
Hye Youn Sung et al.
Although cisplatin is an effective anticancer agent for treating ovarian cancer, it encounters significant resistance. A full understanding of the mechanisms behind cisplatin resistance has not been achieved. This study identifies MBNL2 as ...
VCAM1-mediated regulation of dopaminergic neuron function in Parkinson's disease [0.03%]
血管细胞粘附分子1介导的帕金森病多巴胺能神经元功能调节
Mihee Oh,Sunha Lee,Eunhye Kim et al.
Mihee Oh et al.
Parkinson's disease (PD) is the second most common neurodegenerative disorder, characterized by the degeneration of dopaminergic neurons, striatal dopamine deficiency, and the accumulation of intracellular α-synuclein aggregates. In this s...
Potential use of human pluripotency-related gene expression reporter cell line for screening small molecules to enhance induction of pluripotency [0.03%]
利用与人多能性相关的基因表达报告细胞系筛选增强诱导多能性的小分子药物
Seokbeom Ham,Minseong Lee,Dahee Jeong et al.
Seokbeom Ham et al.
The reprogramming of somatic cells into induced pluripotent stem cells (iPSCs) is a crucial development in regenerative medicine, providing patient-specific cells for therapeutic uses. Traditional methods often utilize viral vectors and tra...
Tissue-specific lncRNA GATA6-AS1 and its ortholog Moshe as essential regulators of aortic valve development [0.03%]
特异性组织长链非编码RNA GATA6-AS1及其同源基因Moshe是主动脉瓣发育的重要调控因子
Na-Jung Kim,Eun-Hye Moon,Ji Hoon Oh et al.
Na-Jung Kim et al.
Long noncoding RNAs (lncRNAs) are integral to epigenetic regulation during cardiogenesis; however, their role in aortic valve disease is not well characterized. Investigating lncRNAs present in the human embryonic heart and pinpointing thei...
Immune tolerance to foreign antigens in the intestine: mechanisms mediated by CD4＋ T cells [0.03%]
肠道对外来抗原的免疫耐受：CD4⁺T细胞介导的机制
Eunbi Yoo,Yeleen Jo,Jooyoun Park et al.
Eunbi Yoo et al.
The immune system encounters a diverse array of antigens, both self and foreign, necessitating mechanisms to maintain tolerance and prevent harmful inflammatory responses. CD4＋ T cells, crucial in orchestrating immune responses, play a criti...
Deubiquitinase dynamics: methodologies for understanding substrate interactions [0.03%]
去泛素酶动力学：理解底物相互作用的方法学研究
Sang-Ah Park,Ji Min Lee
Sang-Ah Park
Deubiquitinases (DUBs) are essential regulators of protein homeostasis that influence cellular signaling, protein stability, and degradation by removing ubiquitin chains from substrate proteins. Understanding DUB-substrate interactions is c...
Jiho Lee,Hye-Lim Mo,Yoon Ha et al.
Jiho Lee et al.
The study of chromatin interactions has advanced considerably with technologies such as high-throughput chromosome conformation capture (Hi-C) sequencing, providing a genome-wide view of physical interactions within the nucleus. These techn...
Role of Arabidopsis monomeric E3 ubiquitin ligases in the ABA signaling pathway [0.03%]
拟南芥单体E3泛素连接酶在ABA信号途径中的作用研究
Sunglan Chung,Su-Jung Lee,Hye Sup Yun et al.
Sunglan Chung et al.
Abscisic acid (ABA) is a key phytohormone that regulates multiple biological processes in plants, including seed germination, seedling growth, and abiotic stress response. ABA enhances drought tolerance by promoting stomatal closure, thereb...
Wei He,Meng Zhang,Yuexia Zhong et al.
Wei He et al.
Limited efficacy and severe side effects often result in suboptimal outcomes to solid tumor therapies. In contrast, the reduced side effects and potential long-term benefits of tumor immunotherapy offer promise, notwithstanding the challeng...
Monocyte activation test (MAT) as an ethical alternative to animal testing [0.03%]
单核细胞激活测试（MAT）作为动物测试的道德替代方案
Yeram Jeon,Soyoung Jeon,Ji-Youn Lim et al.
Yeram Jeon et al.
Ethical considerations surrounding the utilization of animals in scientific research have prompted a widespread search for alternative methodologies. This review explores the historical context and ethical dilemmas associated with tradition...