Molecular analysis of the interaction between ubiquitin-specific protease 7 and large T antigen of Merkel cell polyomavirus [0.03%]
泛素特异性蛋白酶7与 Merkel 细胞多瘤病毒大T抗原相互作用的分子机制分析
Dahwan Lim,Jung-Hwan Park,Ho-Chul Shin et al.
Dahwan Lim et al.
Merkel cell polyomavirus (MCPyV) is the primary causative agent of Merkel cell carcinoma, a rare but highly aggressive neuroendocrine skin cancer. Large T antigen (LT), one of two oncoproteins encoded by MCPyV, sustains the proliferation of...
Preliminary characterization of the skin microbiota in basal cell carcinoma: An exploratory pilot study in Korean patients [0.03%]
韩国基底细胞癌皮肤微生态的初步研究
Hye Lim Keum,Woo Jun Sul,Suyeon Kim et al.
Hye Lim Keum et al.
Basal cell carcinoma (BCC) is the most common form of skin cancer, with ultraviolet radiation recognized as the primary environmental driver; however, the potential contribution of alterations in the skin microbiota remains incompletely und...
Ribosome-associated proteins in fungal ribosome homeostasis: Conceptual opportunities for peptide-based modulation [0.03%]
真菌核糖体稳态中的与核糖体相关的蛋白质：基于肽的调节概念机遇
Yongjun Kim,Chang-Jun Ji,Seohyun Park et al.
Yongjun Kim et al.
Ribosomes are essential macromolecular machines that facilitate protein synthesis and have long been recognized as effective targets for antimicrobial agents. While structural differences between prokaryotic and eukaryotic ribosomes form th...
Ecological characteristics of the truncal skin mycobiome in acne and its association with doxycycline exposure [0.03%]
痤疮患者躯干皮肤真菌微生物组的生态特征及其与多西环素暴露的关系
Hyun Ji Lee,Yong-Joon Cho,Nayan Jin et al.
Hyun Ji Lee et al.
Truncal acne significantly impairs quality of life yet remains underexplored relative to facial acne, particularly with respect to fungal ecology. The trunk represents a distinct cutaneous niche characterized by thicker epidermis, larger fo...
Development of tri-cistronic CLDN18.2 CAR-T cells incorporating PD-1/CD28 switch and cyclophilin A for enhanced solid tumor immunotherapy [0.03%]
开发三顺反式CLDN18.2 CAR-T细胞，结合PD-1 / CD28转换和环孢子素A以增强实体瘤免疫治疗
Heon Ju Lee,Seo Jin Hwang,Eun Hee Jeong et al.
Heon Ju Lee et al.
Chimeric antigen receptor (CAR)-T cell therapy holds significant potential for the treatment of solid tumors. However, immune suppression and tumor-specific barriers limit its application. Claudin 18.2 (CLDN18.2), a gastric lineage-specific...
Sphingomonas degradans sp. nov. and Sphingomonas paludis sp. nov., isolated from the Han River and a wetland in South Korea [0.03%]
解韩国汉江和湿地假单胞菌スピングモナス degradation 菌株和スピングモナス paludis 菌株
Seung-Tae Kim,Miryung Kim,Chang-Jun Cha
Seung-Tae Kim
Two novel bacterial strains, designated CJ20T and CJ99T, belonging to the genus Sphingomonas, were isolated from the Han River in South Korea and a wetland in South Korea, respectively. Cells of both strains were Gram-stain-negative, aerobi...
Effects of sequencing platforms on the profiling of root mycorrhizal communities in Pinus densiflora [0.03%]
测序平台对赤松根系菌根社区分析的影响
Ki Hyeong Park,Seung-Yoon Oh,Shinnam Yoo et al.
Ki Hyeong Park et al.
Next-generation sequencing (NGS) has become a powerful and efficient tool for surveying mycorrhizal mycobiome diversity, surpassing classical methods in accuracy and throughput. Long-read NGS techniques are increasingly applied under the as...
Vitamin D disrupts NS1-TUFM interaction to suppress pathogenic mitophagy in RSV-induced mitochondrial injury of bronchial epithelial cells [0.03%]
维生素D通过干扰RSV_NS1-TUFM相互作用抑制气道上皮细胞中线粒体损伤的病理性自噬 mitochondrion
Li Peng,Yao Liu,Xiaofang Ding et al.
Li Peng et al.
This study aims to examine the mechanism by which vitamin D mitigates bronchiolitis caused by respiratory syncytial virus (RSV) through the regulation of RSV nonstructural protein 1 (NS1)-TUFM-mediated mitophagy in bronchial epithelial cell...
Yu Ri Woo,Hei Sung Kim
Yu Ri Woo
Obesity is increasingly recognized as a systemic pro-inflammatory condition that influences not only metabolic and cardiovascular health but also the development and exacerbation of cutaneous inflammatory diseases. This review examines the ...
The impact of acid mine drainage on nitrogen-fixing microorganisms in rice root zone soil [0.03%]
酸性矿山排水对水稻根区土壤固氮微生物的影响
Shengni Tian,Penghui Zhang,Qin Zhang et al.
Shengni Tian et al.
Acid mine drainage (AMD) poses a serious threat to rice paddy ecosystems, yet its impact on the composition and dynamics of soil nitrogen-fixing microorganisms remains poorly understood. In this study, a pot experiment was conducted using p...