Functional characterization of spike RBD mutations in SARS-CoV-2 Omicron-derived subvariants KP.3.1.1, LP.8.1, and NB.1.8.1 [0.03%]
SARS-CoV-2奥密克戎衍生谱系KP.3.1.1、LP.8.1和NB.1.8.1的刺突RBD突变的功能表征
Yeong Jun Kim,Seon Jae Jeong,Hye-Ra Lee
Yeong Jun Kim
Following the global spread of SARS-CoV-2 Omicron (B.1.1.529), its subvariants KP.3.1.1, LP.8.1, and NB.1.8.1 disseminated worldwide. By April 2025, the epidemiological landscape of these subvariants had become distinct, with LP.8.1 emergin...
I53-50: Engineered icosahedral protein cage for modular vaccine nanoplatform [0.03%]
工程化二十面体蛋白质笼用于模块化疫苗纳米平台
Ke Liang,Shuang Wu,Sihang Dong et al.
Ke Liang et al.
I53-50 is a computationally designed, self-assembling protein nanoparticle (NP) that forms a stable icosahedral structure composed of 120 protein subunits coordinated through precise interfacial interactions. Through unique intelligent regu...
Antimicrobial effects and mechanism of action of carboxymethyl chitosan-loaded silver ion complexes against drug-resistant Aspergillus fumigatus [0.03%]
羧甲基壳聚糖载银离子复合物的抗真菌作用及作用机制研究
Lingsheng Jin,Xinyu Zhou,Wenlong Du
Lingsheng Jin
Based on the escalating challenge of drug-resistant Aspergillus fumigatus infections, this study developed a silver ion-loaded carboxymethyl chitosan (CMCh-Ag⁺) nanocomposite as a potent antifungal agent. The composite was successfully syn...
Byoung Sik Kim
Byoung Sik Kim
Recent trends in dual-acting hybrid antibiotics and combination therapies against Gram-negative pathogens [0.03%]
针对革兰氏阴性病原体的双效杂合抗生素和联合治疗的新趋势
Ji Eun Son,Umji Choi,Gyubin Han et al.
Ji Eun Son et al.
Antibiotic resistance poses a serious challenge to public health worldwide; however, the development of new antibiotic classes for combating bacterial infections, especially those caused by Gram-negative pathogens, has slowed in recent year...
Emerging synthetic biology-assisted technologies for overcoming antibiotic resistance: CRISPR-Cas, bacteriophage, microbiome, and metabolic engineering-based solutions [0.03%]
克服抗生素抗性的新兴合成生物学技术：基于CRISPR-Cas、噬菌体、微生物组和代谢工程的解决方案
Yujeong Oh,Hyunjin Lee,Sungho Jang
Yujeong Oh
Antibiotic resistance has become a critical global health challenge due to the decreased efficacy of existing antibiotics and the emergence of multidrug-resistant pathogens. In particular, the rapid horizontal transfer of resistance genes a...
Structural perspectives on clinical β-lactamase inhibitors: From mechanism to resistance [0.03%]
临床β-内酰胺酶抑制剂的结构观点：从机制到耐药性
Soo-Bong Park,Myeong-Yeon Kim,Sun-Shin Cha
Soo-Bong Park
β-Lactam antibiotics marked the beginning of an era of effective and safe treatment for bacterial infections and remain the most widely prescribed antibacterial agents today. However, the emergence of antibiotic-resistant bacteria threaten...
Genomic landscape reveals the dominance of self-catalytic, high-copy group II introns in PMU-deficient complete genomes of PWB phytoplasmas [0.03%]
基因组测序揭示了PMU缺陷型PWB菌株基因组中自主催化高拷贝的II类内含子占主导地位
Kiran Kirdat,Malad Mubarak,Pradeep Choudhary et al.
Kiran Kirdat et al.
Phytoplasmas are wall-less obligate parasites of plants and insects. Several phytoplasma strains within the Peanut Witches' Broom (PWB; 16SrII) group are associated with significant disease losses across diverse crops and weeds. We present ...
Synthetic rescue in Saccharomyces cerevisiae: Concepts, large-scale genetic mapping, and functional implications [0.03%]
合成营救在酿酒酵母中的作用：概念、大规模基因组定位及其功能意义
Ji Eun Choi,Woo-Hyun Chung
Ji Eun Choi
Synthetic rescue (SR) describes a genetic interaction in which the deleterious effect of a primary mutation is compensated by a second mutation, restoring cellular function or viability. In Saccharomyces cerevisiae, SR complements synthetic...
Inhibitory effects of acetyl-11-keto-β-boswellic acid (AKBA) on human cytomegalovirus (HCMV) in vitro [0.03%]
没药酸乙酯酮(akba)在体外抑制人类巨细胞病毒(hcmv)的作用
Bingquan Chu,Zhiwei Ding,Xinna Wu et al.
Bingquan Chu et al.
This study presents the first investigation of acetyl-11-keto-β-boswellic acid (AKBA)'s anti-human cytomegalovirus (HCMV) activity in vitro and elucidates its underlying mechanisms. In HCMV Towne strain-infected WI-38 cells, AKBA (1-12 μM...