Functional characterization of spike RBD mutations in SARS-CoV-2 Omicron-derived subvariants KP.3.1.1, LP.8.1, and NB.1.8.1 [0.03%]
Yeong Jun Kim,Seon Jae Jeong,Hye-Ra Lee
Yeong Jun Kim
Following the global spread of SARS-CoV-2 Omicron (B.1.1.529), its subvariants KP.3.1.1, LP.8.1, and NB.1.8.1 disseminated worldwide. By April 2025, the epidemiological landscape of these subvariants had become distinct, with LP.8.1 emergin...
Ke Liang,Shuang Wu,Sihang Dong et al.
Ke Liang et al.
I53-50 is a computationally designed, self-assembling protein nanoparticle (NP) that forms a stable icosahedral structure composed of 120 protein subunits coordinated through precise interfacial interactions. Through unique intelligent regu...
Antimicrobial effects and mechanism of action of carboxymethyl chitosan-loaded silver ion complexes against drug-resistant Aspergillus fumigatus [0.03%]
Lingsheng Jin,Xinyu Zhou,Wenlong Du
Lingsheng Jin
Based on the escalating challenge of drug-resistant Aspergillus fumigatus infections, this study developed a silver ion-loaded carboxymethyl chitosan (CMCh-Ag⁺) nanocomposite as a potent antifungal agent. The composite was successfully syn...
Byoung Sik Kim
Byoung Sik Kim
Recent trends in dual-acting hybrid antibiotics and combination therapies against Gram-negative pathogens [0.03%]
Ji Eun Son,Umji Choi,Gyubin Han et al.
Ji Eun Son et al.
Antibiotic resistance poses a serious challenge to public health worldwide; however, the development of new antibiotic classes for combating bacterial infections, especially those caused by Gram-negative pathogens, has slowed in recent year...
Emerging synthetic biology-assisted technologies for overcoming antibiotic resistance: CRISPR-Cas, bacteriophage, microbiome, and metabolic engineering-based solutions [0.03%]
Yujeong Oh,Hyunjin Lee,Sungho Jang
Yujeong Oh
Antibiotic resistance has become a critical global health challenge due to the decreased efficacy of existing antibiotics and the emergence of multidrug-resistant pathogens. In particular, the rapid horizontal transfer of resistance genes a...
Structural perspectives on clinical β-lactamase inhibitors: From mechanism to resistance [0.03%]
临床β-内酰胺酶抑制剂的结构观点：从机制到耐药性
Soo-Bong Park,Myeong-Yeon Kim,Sun-Shin Cha
Soo-Bong Park
β-Lactam antibiotics marked the beginning of an era of effective and safe treatment for bacterial infections and remain the most widely prescribed antibacterial agents today. However, the emergence of antibiotic-resistant bacteria threaten...
Genomic landscape reveals the dominance of self-catalytic, high-copy group II introns in PMU-deficient complete genomes of PWB phytoplasmas [0.03%]
基因组测序揭示了PMU缺陷型PWB菌株基因组中自主催化高拷贝的II类内含子占主导地位
Kiran Kirdat,Malad Mubarak,Pradeep Choudhary et al.
Kiran Kirdat et al.
Phytoplasmas are wall-less obligate parasites of plants and insects. Several phytoplasma strains within the Peanut Witches' Broom (PWB; 16SrII) group are associated with significant disease losses across diverse crops and weeds. We present ...
Synthetic rescue in Saccharomyces cerevisiae: Concepts, large-scale genetic mapping, and functional implications [0.03%]
合成营救在酿酒酵母中的作用：概念、大规模基因组定位及其功能意义
Ji Eun Choi,Woo-Hyun Chung
Ji Eun Choi
Synthetic rescue (SR) describes a genetic interaction in which the deleterious effect of a primary mutation is compensated by a second mutation, restoring cellular function or viability. In Saccharomyces cerevisiae, SR complements synthetic...
Inhibitory effects of acetyl-11-keto-β-boswellic acid (AKBA) on human cytomegalovirus (HCMV) in vitro [0.03%]
没药酸乙酯酮(akba)在体外抑制人类巨细胞病毒(hcmv)的作用
Bingquan Chu,Zhiwei Ding,Xinna Wu et al.
Bingquan Chu et al.
This study presents the first investigation of acetyl-11-keto-β-boswellic acid (AKBA)'s anti-human cytomegalovirus (HCMV) activity in vitro and elucidates its underlying mechanisms. In HCMV Towne strain-infected WI-38 cells, AKBA (1-12 μM...