Hesperidin attenuates learning and memory deficits in APP/PS1 mice through activation of Akt/Nrf2 signaling and inhibition of RAGE/NF-κB signaling [0.03%]
柚皮素通过激活Akt/Nrf2信号途径和抑制RAGE/NF-κB信号通路缓解APP/PS1小鼠的学习和记忆障碍
Yan Hong,Zhongping An
Yan Hong
Numerous studies have demonstrated that oxidative stress and inflammation play a pivotal role in the pathophysiology of Alzheimer disease (AD). Hesperidin (HP) has various pharmacological effects including anti-oxidative, anti-inflammatory ...
Cabozantinib for the treatment of non-small cell lung cancer with KIF5B-RET fusion. An example of swift repositioning [0.03%]
卡博替尼治疗KIF5B-RET融合非小细胞肺癌的再定位案例研究
Minsoo Song,Seong-Heon Kim,Suk Kyoon Yoon
Minsoo Song
A new chimeric fusion transcript of KIF5B (the kinesin family 5B gene) and the RET (Rearranged during Transcription) oncogene, KIF5B-RET, was found in 1-2% of lung adenocarcinomas (LADCs) in 2012. Several related clinical trials for non-sma...
New neo-lignan from Acanthopanax senticosus with protein tyrosine phosphatase 1B inhibitory activity [0.03%]
一种新希夫林及其PTP1B抑制活性
Jia-Lin Li,Na Li,Shan-Shan Xing et al.
Jia-Lin Li et al.
New neo-lignan, (7S, 8R)-3-hydroxyl-4-methoxyl-balanophonin (1), together with seven known compounds (2-8) were isolated from the EtOAc-soluble extract of Acanthopanax senticosus. The structure of the new neo-lignan was elucidated with spec...
Enzymatic synthesis of novel isobavachalcone glucosides via a UDP-glycosyltransferase [0.03%]
一种新型异巴瓦契alcones葡萄糖苷的酶促合成产物及UDP-糖基转移酶的作用机制研究
Hong-Mei Li,Jae Kyoung Lee,Li-Juan Nie et al.
Hong-Mei Li et al.
Glycosylation is often used to improve a natural product's properties such as water solubility, chemical stability, pharmacological potency, and structure diversification. In this study, we studied the enzymatic synthesis of novel isobavach...
Lacidipine self-nanoemulsifying drug delivery system for the enhancement of oral bioavailability [0.03%]
拉西地平自微乳化药物传输系统以增强其口服生物利用度研究
Natesan Subramanian,Shanmugam Palaniappan Sharavanan,Ponnusamy Chandrasekar et al.
Natesan Subramanian et al.
Low bioavailability of Lacidipine (LD), an calcium channel blocker pose many challenges in the treatment of hypertension. The objective of this study was to formulate and characterize LD self-nanoemulsifying drug delivery systems (SNEDDS) t...
Terpenoid composition and the anticancer activity of Acanthopanax trifoliatus [0.03%]
Acanthopanax trifoliatus的倍半萜类成分及其抗肿瘤活性研究
Dong-Li Li,Xi Zheng,Yu-Chan Chen et al.
Dong-Li Li et al.
The petroleum ether and ethyl acetate fractions of extract from an edible and medicinal plant Acanthopanax trifoliatus were found to show significant inhibitory effects against SF-268, MCF-7, HepG2 and NCI-H460 cancer cells. Two new ursane-...
Neuroprotective effect of phytoceramide against transient focal ischemia-induced brain damage in rats [0.03%]
植物神经酰胺对暂时性脑缺血损伤的保护作用研究
Hong Kyu Lee,Ji Yeon Jang,Hwan-Su Yoo et al.
Hong Kyu Lee et al.
The present study was conducted to investigate the protective effect of phytoceramide against focal transient ischemic brain damage and the underlying mechanisms. Focal transient ischemic brain damage was produced in rats by occlusion of th...
Yin-Yang 1 and Yin-Yang 2 exert opposing effects on the promoter activity of interleukin 4 [0.03%]
阴阳1和阴阳2对白细胞介素4启动子活性的作用相反效应
Sung Ho Lee,Young-Chang Cho,Hyung Min Jeong et al.
Sung Ho Lee et al.
Interleukin (IL)-4 acts on T cells as a growth and activation factor, and promotes the differentiation of type 2 T helper cells. In T cells, expression of the gene encoding IL-4 is regulated by inducible or constitutive factors. Yin-Yang (Y...
Nizwaside: a new anticancer pregnane glycoside from the sap of Desmidorchis flava [0.03%]
淡金花叶豆乳胶中新抗癌成分尼瓦西定的化学研究
Hidayat Hussain,Muhammad Adil Raees,Najeeb Ur Rehman et al.
Hidayat Hussain et al.
The sap from the succulent Desmidorchis flava (N.E.Br) Meve and Liede yielded a new pregnane glycoside, named nizwaside whose structure was established using 1D and 2D NMR techniques as well as mass spectrometry (ESIMS). Nizwaside was teste...
Hye-Dong Yoo,Sang-Jip Nam,Young-Won Chin et al.
Hye-Dong Yoo et al.
Natural products are a major pipeline for drug development and are responsible for more than 50 % of drugs on the market. NMR is a fundamental and powerful tool for the structure determination of natural products. It is essential to provide...