Activation of cryptic biosynthetic pathways in Saccharopolyspora spinosa through deletion of the spinosyn gene cluster: induction of cryptic and bioactive natural products [0.03%]
通过删除放线菌素基因簇激活链丝菌隐秘生物合成途径：诱导隐秘生物活性天然产物的生成
Adzemye Fovennso Bridget,Rabin Budhathoki,Chen Huo et al.
Adzemye Fovennso Bridget et al.
Saccharopolyspora spinosa, a member of the Pseudonocardiaceae family, was originally isolated from soil in the Virgin Islands and is renowned for producing spinosad, a broad-spectrum insecticidal secondary metabolite. While research on S. s...
Associations between the gut microbiota and the metabolism rate of tacrolimus in kidney transplant recipients during the early posttransplant period [0.03%]
肠道菌群与肾移植受者早期移植物代谢率的关联研究 tacrolimus
Nahathai Dukaew,Kajohnsak Noppakun,Patcharawadee Thongkumkoon et al.
Nahathai Dukaew et al.
The use of tacrolimus (TAC), a critical immunosuppressant post transplantation, is complicated by its high pharmacokinetic variability. While the gut microbiota has gained attention as a potential contributor, few studies have assessed its ...
Anti-CHI3L1 antibody suppresses colon cancer growth through downregulation of VEGFA and NAMPT expression [0.03%]
抗CHI3L1抗体通过下调VEGFA和NAMPT的表达抑制结肠癌生长
Ji Won Seo,Deok Rim Heo,Ji Eun Yu et al.
Ji Won Seo et al.
Chitinase 3-like 1 (CHI3L1) has been implicated in the pathogenesis of various diseases, including cancer. In our previous study, we found that anti-CHIL1 antibody inhibited lung tumorigenesis. It has been reported that CHI3L1 is highly ove...
Targeting vascular endothelial growth receptor-2 (VEGFR-2): structural biology, functional insights, and therapeutic resistance [0.03%]
靶向血管内皮生长因子受体-2(VEGFR-2)：结构生物学、功能见解和治疗抗性
Fahad Hassan Shah,Yoon Seok Nam,Jun Young Bang et al.
Fahad Hassan Shah et al.
Angiogenesis, the process of new blood vessel formation, is a fundamental physiological process implicated in several pathological disorders. The vascular endothelial growth factors (VEGFs) and their receptors (VEGFRs) are crucial for angio...
Deficiency of β-arrestin2 ameliorates MASLD in mice by promoting the activation of TAK1/AMPK signaling [0.03%]
β- arrestin2缺乏通过促进TAK1 / AMPK信号激活缓解小鼠MASLD
Ting-Ting Chen,Shan Shan,Ya-Ning Chen et al.
Ting-Ting Chen et al.
Metabolic dysfunction-associated steatotic liver disease (MASLD) is a liver manifestation of metabolic syndrome characterized by excessive hepatic lipid accumulation and lipid metabolism disorders. It has become the most common chronic live...
Hye Suk Lee,Sung-Jun Cho,Han Chang Kang et al.
Hye Suk Lee et al.
The growth factor-mediated mitogen-activated protein kinase (MAPK) signaling pathways in cancer development have become increasingly important in the discovery of therapeutic agents for the treatment of cancer. RSK2 has been historically ov...
Mechanistic insights and emerging therapeutic strategies targeting endothelial dysfunction in cardiovascular diseases [0.03%]
心血管疾病中靶向内皮功能障碍的新兴治疗策略及机制研究
Kyung-Sun Heo,Lan Phuong Phan,Nhi Thi Thao Le et al.
Kyung-Sun Heo et al.
Endothelial dysfunction plays a pivotal role in the pathogenesis of various cardiovascular diseases (CVDs), including atherosclerosis, hypertension, heart failure, stroke, and peripheral artery disease. It disrupts vascular homeostasis, lea...
Mohammad Maqusood Alam,Sun Hak Lee,Sobia Wasim et al.
Mohammad Maqusood Alam et al.
Abnormal α-synuclein aggregation is a key neuropathological hallmark of α-synucleinopathies, such as Parkinson's disease (PD), multiple system atrophy (MSA), and several other neurological disorders, and closely contributes to pathogenesi...
A review on bacteria-derived antioxidant metabolites: their production, purification, characterization, potential applications, and limitations [0.03%]
基于细菌的抗氧化代谢物的研究进展：产生、纯化、表征、潜在应用及局限性
Nazli Pinar Arslan,Fakhrul Azad,Tugba Orak et al.
Nazli Pinar Arslan et al.
Antioxidants are organic molecules that scavenge reactive oxygen species (ROS) and reactive nitrogen species (RNS), thereby maintaining cellular redox balance in living organisms. The human body synthesizes endogenous antioxidants, whereas ...
The dynamic roles of macrophages extracellular traps (METs) in immune regulation [0.03%]
巨噬细胞胞外陷阱（METs）在免疫调节中的动态作用
Yunjin Shin,Hanyoung Bae,Chaelin Lee et al.
Yunjin Shin et al.
Macrophages are crucial to innate immunity, eliminating pathogens and damaged tissues through phagocytosis and modulating immune responses. Recently, macrophage extracellular traps (METs) have been identified as chromatin-based structures c...