Insights into biological activities profile of gingerols and shogaols for potential pharmacological applications [0.03%]
姜酚和高良姜素生物活性研究的最新进展及其潜在药用价值
Anis Najwa Abdul Rani,Anand Gaurav,Vannajan Sanghiran Lee et al.
Anis Najwa Abdul Rani et al.
Ginger (Zingiber officinale) rhizome has been widely used in traditional medicine for centuries to promote good health and well-being, treating conditions such as diarrhea, stomach discomfort, nausea, cholera, asthma, and respiratory diseas...
Neuroprotective effects of taurine in a rodent model of parkinson's disease involve modulating astrocyte-mediated inflammation [0.03%]
牛磺酸在帕金森病鼠模型中的神经保护作用涉及调节星形胶质细胞介导的炎症反应
Sung Min Moon,Jaehoon Kim,Jaeheon Seol et al.
Sung Min Moon et al.
Parkinson's disease (PD) is a neurodegenerative disorder characterized by the loss of dopaminergic neurons due to oxidative stress and inflammation. Targeting inflammation and oxidative stress offers a promising means of slowing PD progress...
9H-carbazole derivatives from a Streptomyces species under potassium iodide stress and their anti-inflammatory properties [0.03%]
碘化钾胁迫下链霉菌属物种中9H-咔唑衍生物的抗炎活性研究
Pengcheng Yan,Yunlong Liu,Jibin Liu et al.
Pengcheng Yan et al.
By continuously activating silent gene cluster of the marine-derived Streptomyces strain OUCMDZ-5511 under high salt stress, three new iodinated 9H-carbazole derivatives (1-3) and a novel oxazole-fused chlorinated 9H-carbazole derivative (4...
Silybin inhibits succinate production and secretion in hepatocytes to reverse liver fibrosis [0.03%]
白ksen抑制肝细胞琥珀酸的产生和分泌以逆转肝纤维化
Xule Yang,Yunge Lou,Huan Li et al.
Xule Yang et al.
Silybin has been used as a therapeutic agent in treating liver fibrosis worldwide with unclear mechanisms. In this study, mice were fed a CDAHFD for six weeks to induce liver steatosis and mild liver fibrosis. Metabolomic analysis of mouse ...
Curcumin monoglucuronide protects cartilage from progressive degeneration by blocking MMP-13 [0.03%]
姜黄素单葡萄苷通过阻断MMP-13保护软骨免于进行性退化
Himadri Shekhar Roy,Chirag Kulkarni,K M Neethu et al.
Himadri Shekhar Roy et al.
Collagenases (MMP-1, MMP-8, and MMP-13) play significant roles in the pathophysiology of osteoarthritis. Among these proteins, MMP-13 and MMP-8 are known for their catabolic roles in the degradation of the articular cartilage matrix. Using ...
Targeting NF-κB in diabetic nephropathy: exploring the therapeutic potential of phytoconstituents [0.03%]
针对糖尿病肾病的NF-κB治疗靶点：植物药活性成分的潜在疗效探讨
Beena Levakumar Abhirami,Anithakumari Aswathy Krishna,Alaganandam Kumaran et al.
Beena Levakumar Abhirami et al.
The growing epidemic of diabetes mellitus and its associated complications presents a major global health challenge. Diabetic nephropathy (DN) is a critical microvascular complication of diabetes, accounts for approximately one-third of all...
Sphingolipid modulation and anti-tumor activity of Jaspine B in HepG2 bearing mice [0.03%]
Jaspine B通过调节鞘脂发挥抗肿瘤活性作用
Jihoon Lee,Ji-Hyeon Jeon,Minyeong Pang et al.
Jihoon Lee et al.
The cytotoxicity of Jaspine B was evaluated across a concentration range of 0.5-50 μM, yielding a half maximal inhibitory concentration (IC50) of 2.6 μM for HepG2 human hepatocellular carcinoma cells. To explore the mechanisms of Jaspine ...
Emerging concepts and challenges in the development of disease-modifying osteoarthritis drugs - a more refined perspective [0.03%]
骨关节炎疾病修饰药物开发的新概念和挑战——一个更为精炼的视角
Zsuzsa Jenei-Lanzl,Svenja Maurer,Rolf E Brenner et al.
Zsuzsa Jenei-Lanzl et al.
Osteoarthritis (OA) is the most common joint disease worldwide. Despite significant efforts byresearchers, no disease-modifying osteoarthritis drugs (DMOADs) have been approved yet. This review compares preclinical and clinical studies of p...
Evaluation of bone health and fracture risk in type 2 diabetes: a network meta-analysis of anti-diabetic treatments versus placebo [0.03%]
二甲双胍等降糖药物治疗对糖尿病患者骨密度和骨折风险的网络meta分析研究
SuA Oh,Se-Eun Park,Eunyoung Kim
SuA Oh
While studies have highlighted the negative effects of certain antidiabetic agents, similar evidence for other antidiabetic agents remains limited. In this study, we aimed to analyze bone fractures and bone mineral densities (BMDs) across p...
Oleanolic acid activates the JNK-Sp1-DJ-1 axis to promote mitophagy-mediated neuroprotection in dopaminergic neurons for Parkinson's disease treatment [0.03%]
白桦酸通过激活JNK-SP1-DJ-1轴促进多巴胺能神经元自噬介导的神经保护作用以治疗帕金森病
Han-Bin Yang,Chien-Hsing Lee,Nguyen Thao Nhung et al.
Han-Bin Yang et al.
Parkinson's disease (PD) is a prevalent neurodegenerative disorder marked by mitochondrial dysfunction and oxidative stress. Although levodopa remains the gold standard for managing PD motor symptoms, it lacks neuroprotective and disease-mo...