Histone demethylase KDM4C confers temozolomide resistance to glioblastoma cells by epigenetically regulating E2F6 [0.03%]
组蛋白去甲基化酶KDM4C通过表观遗传调控E2F6介导胶质母细胞瘤的替莫唑胺耐药性
Go Woon Kim,Dong Hoon Lee,Jung Yoo et al.
Go Woon Kim et al.
Glioblastoma (GBM) is the most aggressive and deadliest type of primary brain tumor, treated with temozolomide (TMZ) as first-line chemotherapy. However, temozolomide resistance remains a critical therapeutic hurdle in GBM, often resulting ...
Effects of polyphenols on cancer cell progression mediated by inhibition of cyclin-dependent kinases (CDKs): the emerging drug targets in cancer [0.03%]
酚类物质通过抑制细胞周期蛋白依赖性激酶(CDKs)介导的癌症细胞进程的影响：癌症中新兴的药物作用靶点
Abdul Basit,Shun Wen,Siyuan Wang
Abdul Basit
Cancer remains a critical global health issue, presenting multifaceted challenges in both prevention and treatment. It is characterized by uncontrolled cell proliferation, primarily driven by the dysregulation of cyclin-dependent kinases (C...
Cartilage extracellular matrix regeneration with 10-gingerol via KEAP1-NRF2-ARE axis for osteoarthritis therapy [0.03%]
通过KEAP1-NRF2-ARE轴使用姜酚进行软骨细胞外基质再生以治疗骨关节炎
Yibo Ma,Chenhao Sun,Zongyue Wang et al.
Yibo Ma et al.
Osteoarthritis (OA) is characterized by oxidative stress, inflammation, and apoptosis, leading to an imbalance between cartilage extracellular matrix (ECM) synthesis and degradation. Gingerols can regulate multiple biological activities, in...
Site-selective addition of succinimide motif through nitro-assisted C-H functionalization of (hetero) arenes under rhodium catalysis [0.03%]
硝基协助的金属催化芳烃C-H活化/环加成串联反应合成四氢吡咯类化合物
Amitava Rakshit,Dabeen Lim,Jiheun Hyun et al.
Amitava Rakshit et al.
Succinimide motifs are recognized as privileged cores in anticonvulsants and antipsychotics such as phensuximide, ethosuximide, and lurasidone. These succinimides can be readily converted into pharmaceutically important pyrrolidines and γ-...
Salvianolic acid A enhances Treg accumulation via the RUNX1/CBFβ/FOXP3 axis as a neuroprotective immunomodulator in ischemic stroke [0.03%]
_salvianolic酸A通过RUNX1/CBFβ/FOXP3轴增强Treg募集作为缺血性脑卒中的神经保护免疫调节剂
Jiayang Wu,Kui Liu,Jinqian Song et al.
Jiayang Wu et al.
Salvianolic acid A (SAA), a major water-soluble bioactive compound extracted from Salvia miltiorrhiza, has been extensively studied for its diverse pharmacological properties in cerebrovascular diseases. However, its immunomodulatory effect...
Comparative analysis of LJ-4378 and tirzepatide in mouse models of obesity and weight regain [0.03%]
LJ-4378与Tirzepatide在肥胖和体重反弹小鼠模型中的比较研究分析
Heeseong Kim,Seung Woo Kim,Cheoljun Choi et al.
Heeseong Kim et al.
We previously developed LJ-4378, a dual ligand for A2A and A3 adenosine receptors, as a potential anti-obesity agent. In this study, we compared the anti-obesity effects of LJ-4378 with those of tirzepatide (TZP), a dual agonist of glucagon...
Structure, biological activity, and biosynthesis of natural chromanes and chromenes [0.03%]
天然色满和色氧满的结构、生物活性及生物合成
Ying Liu,Yang Xu,Na Zhang et al.
Ying Liu et al.
Chromanes and chromenes with various biological activities are widespread in nature and have now been found in a variety of plants, fungi and marine organisms. To date, 79 previously undescribed chromanes and 161 previously undescribed chro...
Resmetirom, the first FDA-approved drug for MASH: From drug discovery and action mechanisms to clinical trials [0.03%]
口服药物Resmetirom治疗肝硬化前期组织损伤：从发现、作用机制到临床试验
Jiaman Liu,Fenghua Yang,Boya Gao et al.
Jiaman Liu et al.
Metabolically-dysfunction-associated steatohepatitis (MASH) represents one spectrum of MASLD, affecting over 5.27% of adults globally. Until the approval of resmetirom, no pharmacological therapies were available for MASH. Resmetirom is pre...
Curcumin for inflammatory bowel disease therapy: advances in mechanisms, clinical applications, and drug delivery [0.03%]
姜黄素在治疗炎症性肠病中的作用：机制、临床应用和药物递送方面的进展
Zilong Zhang,Chao Ding,Haonan Xu et al.
Zilong Zhang et al.
Inflammatory bowel disease (IBD) is a chronic and recurrent gastrointestinal disorder, which is typically characterized by symptoms such as abdominal pain, diarrhea, and weight loss, significantly impairing patients' quality of life. The et...
Germacrane and humulane sesquiterpenes from the roots and rhizomes of Valeriana officinalis var. latifolia and their anti-inflammatory and anti-influenza virus activities [0.03%]
牻牛儿苗内酯和蛇麻内酯从缬草根及根茎中的分离及其抗炎和抗流感病毒活性研究
Jia-Jin Liu,Li-Zhong Wang,Yuan-Ting Duan et al.
Jia-Jin Liu et al.
Twenty-seven sesquiterpenes, including twenty-one new germacrane-type ones (1-5, 8-16, and 19-25) and a new humulane-type one (27), were isolated from the roots and rhizomes of Valeriana officinalis var. latifolia. The structures and absolu...