PBPK modeling of the antidepressant doxepin incorporating CYP2D6 genotype for precision pharmacotherapy [0.03%]
基于CYP2D6基因型的抗抑郁药物多塞平的PBPK建模以实现精准治疗
Joohee Seok,Nahyun Kang,Je Jin Lee et al.
Joohee Seok et al.
Doxepin, a tricyclic antidepressant, exhibits substantial interindividual variability in pharmacokinetics, mainly attributable to genetic polymorphisms of cytochrome P450 (CYP) enzymes, particularly CYP2D6. Such variability may lead to clin...
Neuroinflammation and blood-brain barrier disruption in Japanese encephalitis virus infection: mechanisms, therapeutic targets, and intervention strategies [0.03%]
日本脑炎病毒神经炎症和血脑屏障破坏的机制、治疗靶点及干预策略
Xiaochun Ye,Ping Wang,Mengping Song et al.
Xiaochun Ye et al.
Japanese encephalitis virus (JEV), as a neurotropic flavivirus, remains a primary cause of viral encephalitis and poses a significant public health challenge. Its pathogenic mechanism centers on the pathological interaction between blood-br...
JAK2/STAT3-dependent regulation of MDM4/MDM2-p53 signaling in methotrexate-induced ferroptosis and nephrotoxicity [0.03%]
甲氨蝶呤诱导的铁死亡及其肾毒性的Janus激活激酶2/信号转导子和转录活化子3依赖性调节/mdm4/MDM2-p53信号轴
Yu Cheng,Mingming Zhao,Yujia Zhang et al.
Yu Cheng et al.
Methotrexate (MTX), a cornerstone therapeutic agent for malignancies and autoimmune diseases, is clinically constrained by its severe nephrotoxic effects. Although oxidative stress and apoptosis have been implicated in MTX-induced nephrotox...
Bispecific antibody-drug conjugates: a modular blueprint for next-generation cancer therapeutics [0.03%]
双特异抗体药物偶联物：下一代抗癌治疗的模块化蓝图
Yulin Bai,Huaqing Lei,Shuang Gou et al.
Yulin Bai et al.
Antibody-drug conjugates (ADCs) have rapidly developed over the past two decades as a class of targeted anticancer agents. These drugs deliver highly cytotoxic payloads conjugated to specific antibodies, targeting cancer cells and releasing...
Discovery of a potent STAT3 inhibitor WR-S-647 for the treatment of ADPKD [0.03%]
用于治疗ADPKD的强效STAT3抑制剂WR-S-647的发现
Zhaoyong Kang,Wenchao Zhao,Wangrui Jin et al.
Zhaoyong Kang et al.
Autosomal dominant polycystic kidney disease (ADPKD) affects approximately 12.5 million individuals globally and is one of the most common causes of end-stage renal disease. It is typically associated with a gradual increase in the volume o...
PF protects retinal pigment epithelial cells from oxidative injury by enhancing mitophagy through a CUL3-dependent AMPK/ULK1 pathway [0.03%]
PF通过CUL3依赖的AMPK/ULK1通路增强线粒体自噬来保护视网膜色素上皮细胞免受氧化损伤
Xi Chen,Wei Shi,Yujie Zhu et al.
Xi Chen et al.
Mitophagy dysfunction is a critical contributor to retinal pigment epithelial (RPE) cell damage during the progression of retinal degenerative diseases, including age-related macular degeneration (AMD). In this study, we investigated the ef...
Ischemic stroke neuroprotection revisited: translational barriers and a phase-resolved, biomarker-anchored framework [0.03%]
缺血性卒中神经保护再探：转化障碍及分期解析和生物标志物锚定框架
Sam Seok Cho,Eun Jin Shin,Yun Gyeong Kim et al.
Sam Seok Cho et al.
Despite extensive research defining the molecular cascades of ischemic stroke, including excitotoxicity, oxidative stress, inflammation, blood-brain barrier disruption, and regulated cell death, translation of neuroprotective strategies int...
cis-Clerodane-type diterpenoids from Tinospora crispa and their anticancer potential [0.03%]
取藤蛇钩藤素中齐克洛丹型二萜类成分及其抗肿瘤活性
Se Yun Jeong,Jisun Kim,Ji Won Ha et al.
Se Yun Jeong et al.
Tinospora crispa (Menispermaceae) has been traditionally consumed as a functional food and herbal remedy in Southeast Asia, notably in Thailand and India. cis-Clerodane-type diterpenoids represent the characteristic and predominant metaboli...
Correction to: Resveratrol ameliorates liver fibrosis by inhibiting ATF4 to regulate glutamine metabolism in hepatic stellate cells [0.03%]
白藜芦醇通过抑制ATF4调节肝星状细胞谷氨酰胺代谢从而改善肝纤维化纠正：错误原文: 白藜芦醇通过抑制ATF4调节肝星状细胞谷氨酰胺代谢从而改善肝纤维化
Huiya Ying,Yixiao Wang,Dandan Zhu et al.
Huiya Ying et al.
Published Erratum
Archives of pharmacal research. 2026 Jan 19. DOI:10.1007/s12272-026-01592-2 2026
Unlocking drug development: the distinctive roles of PET and SPECT imaging from molecular kinetics to therapeutic response [0.03%]
解药物开发之锁：从分子动力学到治疗反应PET和SPECT成像的独特作用
Sun Mi Park,Joo Yeon Park,Tae Sup Lee et al.
Sun Mi Park et al.
Drug development is a multifaceted and time-intensive process that spans candidate discovery, formulation, pharmacokinetics (PK), and evaluation of therapeutic efficacy and safety. Nuclear medicine imaging-particularly positron emission tom...