Unraveling regorafenib resistance: metabolic reprogramming, tumor plasticity, and novel approaches to overcome therapy failure [0.03%]
解开regorafenib耐药性：代谢重编程、肿瘤可塑性和克服治疗失败的新方法
Xiaokun Liu,Xiao Gao,Yuling Yang et al.
Xiaokun Liu et al.
Regorafenib, a multi-kinase inhibitor, has demonstrated clinical efficacy in various malignancies, including hepatocellular carcinoma (HCC), colorectal cancer (CRC), and gastrointestinal stromal tumors (GISTs). However, the emergence of res...
Recent paclitaxel formulation strategies: expanding the therapeutic index by addressing biopharmaceutical and toxicity limitations [0.03%]
近期的紫杉醇制剂策略：通过解决药物剂型和毒性限制来扩大治疗指数
Jihoon Lee,Min-Koo Choi,Im-Sook Song
Jihoon Lee
Paclitaxel (PTX) is a standard-of-care antineoplastic agent that stabilizes microtubules. However, its clinical utility is limited by dose limiting toxicities (e.g., myelosuppression and neuropathy), influencing decades of formulation devel...
Entrectinib attenuates LPS-induced neuroinflammation by inhibiting JNK, p38, and AKT pathways and ameliorates cognitive impairment [0.03%]
艾瑞替尼通过抑制JNK、p38和AKT通路缓解LPS诱导的神经炎症并改善认知障碍
Hanwoong Woo,Sung Wook Kim,Sohee Kim et al.
Hanwoong Woo et al.
Entrectinib, a Food and Drug Administration-approved medication for cancers such as non-small cell lung cancer, inhibits tropomyosin receptor kinases and penetrates the blood-brain barrier. Despite its approval, the effects of Entrectinib o...
Tirzepatide mitigates atherosclerosis progression and modulates oxLDL-mediated proatherogenic effects in macrophages: evidence for M1/M2 homeostasis restoration [0.03%]
tirzepatide减轻动脉粥样硬化进展并调节oxldl介导的单核细胞泡沫化和巨噬细胞向促炎M1表型分化：恢复M1/m2平衡的证据
Mengjie Kang,HaoLin Ren,Yanru Zhen et al.
Mengjie Kang et al.
Tirzepatide (TZP), a novel dual agonist of glucagon-like peptide (GLP)-1/glucose-dependent insulinotropic polypeptide (GIP) receptors (GLP-1R/GIPR), has been shown to reduce cardiovascular (CV) risk in patients with diabetes or obesity. Thi...
Bavachin suppresses NF-κB signaling and angiogenic pathways to alleviate rheumatoid arthritis [0.03%]
Bavachin通过抑制NF-κB信号通路和血管生成途径来缓解类风湿关节炎
Debolina Chakraborty,Swati Malik,Ashish Sarkar et al.
Debolina Chakraborty et al.
Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory joint disorder that primarily affects females. Estrogen deficiency plays a key role in its development, prompting interest in phytoestrogens as safer alternatives to synthetic e...
Artemisinin attenuates 3-nitropropionic acid-induced neurodegeneration via HMGB1/TLR4/NF-κB modulation in a rat model of huntington's disease [0.03%]
青蒿素通过调节Hmgb1/Tlr4/Nf-κb信号途径缓解 Huntington 模型小鼠中 3-硝基丙酸诱导的神经退行性病变
Aya M Mustafa,Mustafa Mudhafar,Ali M Elgindy et al.
Aya M Mustafa et al.
Huntington's disease (HD) is a progressive neurodegenerative disorder characterized by motor, cognitive, and behavioral impairments associated with striatal neuronal loss, for which effective symptom-attenuating therapies remain lacking. Ar...
Nanostructured branched Y-DNA promotes antitumor immunity through dual activation of cGAS/STING and TLR9 [0.03%]
纳米结构分支型Y型DNA通过激活cGAS/STING和TLR9促进抗肿瘤免疫
Jin Kyung Seok,Jung In Jee,Jong Han Oh et al.
Jin Kyung Seok et al.
Effective activation of innate and adaptive immunity remains a major challenge in cancer immunotherapy. In this study, we aimed to develop an immunostimulatory oligonucleotides for antitumor immunotherapy. We designed branched Y-shaped DNA ...
Mechanisms and structure-activity relationship of hypolipidemic effects of polysaccharides from natural resources: a review [0.03%]
天然资源多糖降脂作用机制及构效关系的研究进展
Yao Wu,Yuying Zhang,Chuanming Gong et al.
Yao Wu et al.
Hyperlipidemia, characterized by aberrant lipid metabolism, constitutes a pivotal risk factor for cardiovascular diseases (CVDs) and contributes to various metabolic complications. Although conventional lipid-lowering agents are widely used...
Homoharringtonine inhibits growth and migration in non-small cell lung cancer via PDIA4-mediated modulation of autophagy and EMT [0.03%]
PDIA4介导的自噬和EMT调节介导的同环辛啶抑制非小细胞肺癌的生长和迁移
Xiaoyu Ma,Panpan Lei,Bingxi Ren et al.
Xiaoyu Ma et al.
Protein disulfide isomerase A4 (PDIA4) is overexpressed in non-small cell lung cancer (NSCLC) and is associated with poor prognosis. This study demonstrates that elevated PDIA4 expression promotes NSCLC progression, whereas its knockdown in...
P7C3 alleviates hepatic fibrosis via targeting eIF4A1-mediated protein translation and autophagy in hepatic stellate cells [0.03%]
P7C3通过靶向激活肝星状细胞中eIF4A1介导的蛋白质翻译和自噬来缓解肝纤维化
Ailing Liang,Ling Yao,Yuanyuan Liu et al.
Ailing Liang et al.
P7C3, an aminopropyl carbazole compound with established neuroprotective properties and therapeutic potential in neurodegenerative disorders, has demonstrated broad pharmacological activity across multiple pathologies. However, the effect o...