Naringenin enhances NK cell lysis activity by increasing the expression of NKG2D ligands on Burkitt's lymphoma cells [0.03%]
纳芦辛通过增加Burkitt淋巴瘤细胞上NKG2D配体的表达来增强NK细胞裂解活性
Jeong Hwa Kim,Jae Kwon Lee
Jeong Hwa Kim
Natural killer (NK) cells are capable of identifying and killing tumor cells as well as virus infected cells without pre-sensitization. NK cells express activating and inhibitory receptors, and can distinguish between normal and tumor cells...
Synthesis of biscoumarin and dihydropyran derivatives as two novel classes of potential anti-bacterial derivatives [0.03%]
两类新的潜在抗菌衍生物的合成：茋二耦和二氢吡喃类化合物
Jing Li,Xiao-Yan Xue,Xia Li et al.
Jing Li et al.
A series of bisoumarin (1-4) and dihydropyran (5-8) derivatives were successfully synthesized as new antibacterial agents. The molecular structures of three representative compounds 1, 5 and 7 were confirmed by single crystal X-ray diffract...
Octahydrocyclopenta[c]pyridine and octahydrocyclopenta[c]pyran analogues as a protease activated receptor 1 (PAR1) antagonist [0.03%]
八氢环戊基[c]吡啶和八氢环戊基[c]吡喃类似物作为蛋白酶激活受体1(PAR1)拮抗剂
Abdul Wadood,Haejin Kim,Chul Min Park et al.
Abdul Wadood et al.
Protease activated receptor 1 (PAR1) has been considered as a promising antiplatelet target to prevent thrombotic cardiovascular events in patients with prior myocardial infarction or peripheral arterial diseases. Previously, we found a ser...
Comparative Study
Archives of pharmacal research. 2015 Nov;38(11):2029-41. DOI:10.1007/s12272-015-0623-6 2015
Synthesis and anticancer activity of 4-aza-daurinol derivatives [0.03%]
4-aza-daunorubicin衍生物的合成及其抗肿瘤活性研究
Faisal Hayat,Seung-Hyuk Park,Nam-Song Choi et al.
Faisal Hayat et al.
Daurinol, a natural aryl naphthalene lactone, has been reported to have antiproliferative activity against various cell lines, and has also been shown to be efficacious in an in vivo xenograft mouse model. In this study, we tried to discove...
Comparative Study
Archives of pharmacal research. 2015 Nov;38(11):1975-82. DOI:10.1007/s12272-015-0619-2 2015
Anti-inflammatory and anticholinesterase activity of six flavonoids isolated from Polygonum and Dorstenia species [0.03%]
六种Polygonum和Dorstenia属植物黄酮类化合物的抗炎及抗胆碱酯酶活性研究
Jean Paul Dzoyem,Antoine H L Nkuete,Barthelemy Ngameni et al.
Jean Paul Dzoyem et al.
This study was aimed at investigating the anti-inflammatory and anticholinesterase activity of six naturally occurring flavonoids: (-) pinostrobin (1), 2',4'-dihydroxy-3',6'-dimethoxychalcone (2), 6-8-diprenyleriodictyol (3), isobavachalcon...
Target deconvolution of bioactive small molecules: the heart of chemical biology and drug discovery [0.03%]
活性小分子的作用靶点鉴定：化学生物学和新药研发之核心问题
Hye Jin Jung,Ho Jeong Kwon
Hye Jin Jung
Identification of the target proteins of bioactive small molecules isolated from phenotypic screens plays an important role in chemical biology and drug discovery. However, discovering the targets of small molecules is often the most challe...
A new 9,11-secosterol with a 1,4-quinone from a Korean marine sponge Ircinia sp [0.03%]
来自韩国海洋海绵Ircinia sp的一种新的具有1,4-醌结构的9,11-secosterol化合物
Inho Yang,Hyukjae Choi,Sang-Jip Nam et al.
Inho Yang et al.
An intensive investigation of chemical components for Ircinia sp. led to the isolation of a new 9,11-secosterol. The chemical structure of this compound was elucidated based on the interpretation of NMR and MS spectroscopic data. The isolat...
Development of fluorescent probes that bind and stain amyloid plaques in Alzheimer's disease [0.03%]
用于结合并染色阿尔茨海默病中的淀粉样斑块的荧光探针的发展
Seung-Jin Jung,Seung-Hwan Park,Eun Je Lee et al.
Seung-Jin Jung et al.
β-amyloid (Aβ) plaques in the brain are composed of Aβ40 and Aβ42 peptides, and are the defining pathological feature of Alzheimer's disease (AD). Fluorescent probes that can detect Aβ plaques have gained increasing interest as potenti...
Immune modulation of glycosaminoglycan derived from P. lewisi in TNF-α stimulated cells [0.03%]
源自P. lewisi的甘氨糖胺聚糖对TNF-α刺激细胞免疫调节的作用
Mi-Young Ahn,Soon-Ja Kim,NamJung Kim et al.
Mi-Young Ahn et al.
Poecilocoris lewisi (Korean name: "Kwangdaenolinjae") is a red-striped gold stink bug (insect) which has been used as a crude drug in traditional medicine of East Asia and Korea. In this study, ethanol extract and glycosaminoglycan from P. ...
Isoprenylated flavonoids from the root bark of Morus alba and their hepatoprotective and neuroprotective activities [0.03%]
白 mulberry 根皮中的异戊二烯黄烷醇及其保肝和神经营养活性
Jae-Woo Jung,Won-Min Ko,Ji-Hae Park et al.
Jae-Woo Jung et al.
A new isoprenylated flavonoid, 2S-5,7,2',4'-tetrahydroxy-3',5'-di-(γ,γ-dimethylallyl)flavanone, sanggenol Q (1), along with seven known isoprenylated flavonoids, sanggenol A (2), sanggenol L (3), kuwanon T (4), cyclomorusin (5), sanggenon...