Identification of a thienopyrimidine derivatives target by a kinome and chemical biology approach [0.03%]
采用激酶组和化学生物学方法鉴定一类噻二吡啶衍生物的作用靶点
Chulho Lee,Jee Sun Yang,Gyoonhee Han
Chulho Lee
Target identification through chemical biology has been considered one of the most efficient approaches for drug discovery. Thienopyrimidine derivatives were designed to discover potent IκB kinase β (IKKβ) inhibitors based on a known IKK...
Preparation and evaluation of enteric-coated delayed-release pellets of duloxetine hydrochloride using a fluidized bed coater [0.03%]
采用流化床包衣机制备盐酸度洛西汀肠溶缓释微丸及其评价研究
Yong-Il Kim,Roshan Pradhan,Bijay K Paudel et al.
Yong-Il Kim et al.
In this study, the enteric-coated delayed-release pellets of duloxetine hydrochloride (DLX) were formulated using a fluidized bed coater. Three separate layers, the drug layer, the barrier layer, and the enteric layer, were coated onto iner...
Chemical biology of compounds obtained from screening using disease models [0.03%]
基于疾病模型筛选所得化合物的化学生物学研究
Estu Tashiro,Masaya Imoto
Estu Tashiro
Bioactive compounds are extremely powerful tools for studying biological systems because they can rapidly, conditionally, often reversibly, and dose-dependently modulate the biological function of living cells. Moreover, they are expected t...
Triterpenoids isolated from the rhizomes and roots of Gentiana scabra and their inhibition of indoleamine 2,3-dioxygenase [0.03%]
从龙胆根及根茎中分离得到的三萜类成分及其对吲哚胺2，3-双氧酶的抑制作用
Wei Li,Lin Ying Li,Wei Zhou et al.
Wei Li et al.
Gentiana scabra Bunge (Gentianaceae) is an important traditional Chinese medicine commonly used as a stomachic or appetite stimulant. In this study, 21 triterpenoids (1-21) were isolated from a methanol extract of the rhizomes and roots of ...
Saponin from the fruit of Solanum anguivi protects against oxidative damage mediated by Fe2+ and sodium nitroprusside in rat brain synaptosome P2 fraction [0.03%]
用脑突触体P2片段研究Solanum anguivi果提取物皂苷抗氧化及抗神经细胞损伤作用
Olusola Olalekan Elekofehinti,Jean Paul Kamdem,Daiane Francine Meinerz et al.
Olusola Olalekan Elekofehinti et al.
Solanum anguivi fruit saponin has antidiabetic property via interference with cellular energy metabolism and inhibition of reactive oxygen species (ROS) generation. In the current study, brain specific in vitro anti-oxidant role of S. angui...
Preparation and performance evaluation of emulsomes as a drug delivery system for silybin [0.03%]
乳剂型胶束作为水飞蓟宾药物传递系统的研究及评价
Xiaodan Zhou,Zhipeng Chen
Xiaodan Zhou
We developed silybin (SIL) emulsomes and evaluated their physicochemical properties and the in vivo pharmacokinetics of SIL delivered by emulsomes in rats. SIL emulsomes were prepared using the thin film dispersion method. SIL emulsomes wer...
Anti-diabetic and anti-Alzheimer's disease activities of Angelica decursiva [0.03%]
Angelica decursiva的降血糖及抗阿茨海默症活性研究
Md Yousof Ali,Hyun Ah Jung,Jae Sue Choi
Md Yousof Ali
Diabetes mellitus (DM) and Alzheimer's disease (AD) constitute two global health issues. DM is an ever-increasing epidemic affecting millions of elderly people worldwide, causing major repercussions on patients' daily lives, mostly due to c...
Existing drugs and their application in drug discovery targeting cancer stem cells [0.03%]
抗癌药物筛选及现有药物再定位在癌症干细胞研究中的应用
Junfang Lv,Joong Sup Shim
Junfang Lv
Despite standard cancer therapies such as chemotherapy and targeted therapy have shown some efficacies, the cancer in many cases eventually relapses and metastasizes upon stopping the treatment. There is a small subpopulation of cancer cell...
Anti-adipogenic effect of epiberberine is mediated by regulation of the Raf/MEK1/2/ERK1/2 and AMPKα/Akt pathways [0.03%]
黄连碱通过调节Raf/MEK1/2/ERK1/2和AMPKα/Akt信号通路发挥抗肥胖作用
Jae Sue Choi,Ji-Hye Kim,Md Yousof Ali et al.
Jae Sue Choi et al.
It has been reported that alkaloids derived from Coptis chinensis exert anti-adipogenic activity on 3T3-L1 adipocytes by downregulating peroxisome proliferation-activity receptor-γ (PPAR-γ) and CCAAT/enhancer binding protein-α (C/EBP-α)...
Naringenin enhances NK cell lysis activity by increasing the expression of NKG2D ligands on Burkitt's lymphoma cells [0.03%]
纳芦辛通过增加Burkitt淋巴瘤细胞上NKG2D配体的表达来增强NK细胞裂解活性
Jeong Hwa Kim,Jae Kwon Lee
Jeong Hwa Kim
Natural killer (NK) cells are capable of identifying and killing tumor cells as well as virus infected cells without pre-sensitization. NK cells express activating and inhibitory receptors, and can distinguish between normal and tumor cells...