Effects of fluconazole on the pharmacokinetics of celecoxib and its carboxylic acid metabolite in different CYP2C9 genotypes [0.03%]
氟康唑对不同CYP2C9基因型中塞来昔布及其羧酸代谢产物药代动力学的影响
Chang-Keun Cho,Pureum Kang,Choon-Gon Jang et al.
Chang-Keun Cho et al.
This study aimed to investigate the effects of fluconazole, a moderate inhibitor of CYP2C9 and CYP3A4, on the pharmacokinetics of celecoxib and its carboxylic acid metabolite in different CYP2C9 genotypes. A total of thirty-nine healthy Kor...
Immunosenescence and age-related immune cells: causes of age-related diseases [0.03%]
免疫衰老和与年龄相关的免疫细胞：导致与年龄相关疾病的原因
Nam-Hee Kim,So-Jin Sim,Hong-Gyu Han et al.
Nam-Hee Kim et al.
Immunosenescence is a weakening of the immune system due to aging, characterized by changes in immune cells and dysregulated immune function. Age-related immune cells are increasing with aging. They are associated with chronic prolonged inf...
Three new xanthones and other anti-inflammatory components from the aerial parts of Hypericum beanii [0.03%]
采自喜马薄叶红景天的三个新丹参素及其他抗炎成分
Wei Ma,Fu-Cai Ren,Xue-Ru Wang et al.
Wei Ma et al.
Hypericum beanii, a traditional folk medicine plant, has been employed in treating various inflammation-related diseases. In this study, three new prenylated xanthones, named beanigenin A (1), beanigenin B (2), and beanigenin C (3), along w...
Ideal animal models according to multifaceted mechanisms and peculiarities in neurological disorders: present and challenges [0.03%]
多面机制和特异性神经疾病的理想动物模型：现状与挑战
Shrawani Lamichhane,Jo-Eun Seo,Ji Hoon Jeong et al.
Shrawani Lamichhane et al.
Neurological disorders, encompassing conditions such as Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), and amyotrophic lateral sclerosis (ALS), pose a significant global health challenge, affecting millions w...
Cell membrane chromatography relative competitive method for the accurate determination of relative KD values of drug-receptor interactions [0.03%]
细胞膜色谱相对竞争法精准测定药物与受体相互作用的相对平衡解离常数
Panpan Lei,Weina Ma,Jiapan Gao et al.
Panpan Lei et al.
The specific binding of a drug to the receptor is a prerequisite for its action. The equilibrium dissociation constant (KD) is an important parameter for measuring the strength of drug-receptor interactions. Cell membrane chromatography (CM...
Exploring β-caryophyllene: a non-psychotropic cannabinoid's potential in mitigating cognitive impairment induced by sleep deprivation [0.03%]
探究β-石竹烯：非精神活性的大麻二酚在缓解睡眠剥夺引起的认知障碍方面的潜力
Cher Ryn Lim,Satoshi Ogawa,Yatinesh Kumari
Cher Ryn Lim
Sleep deprivation or sleep loss, a prevalent issue in modern society, is linked to cognitive impairment, leading to heightened risks of errors and accidents. Chronic sleep deprivation affects various cognitive functions, including memory, a...
Biological insights and therapeutic potential of Glycyrrhiza uralensis and its bioactive compounds: an updated review [0.03%]
甘草及其活性成分的生物学见解和治疗潜力：最新综述
Sibhghatulla Shaikh,Khurshid Ahmad,Jeong Ho Lim et al.
Sibhghatulla Shaikh et al.
The recent resurgence of traditional medicines, driven by a renewed interest in the medicinal use of plant extracts, has garnered significant scientific attention for their therapeutic efficacy in treating a wide range of diseases. Glycyrrh...
Curcumin targets CXCL16-mediated podocyte injury and lipid accumulation in diabetic kidney disease treatment [0.03%]
姜黄素通过靶向CXCL16介导的肾小球足细胞损伤和脂质蓄积治疗糖尿病肾脏疾病
Ying Chen,Jun Tao,Yijun He et al.
Ying Chen et al.
Among the complications of diabetes, diabetic kidney disease (DKD) frequently emerges, typified by the detrimental effects on renal function, manifesting through inflammation, dysregulated lipid metabolism, and harm to podocytes. Existing r...
Jeongwoo Park,Eun Jin Shin,Tae Hyun Kim et al.
Jeongwoo Park et al.
Cellular metabolism-related epigenetic modulation plays a pivotal role in the maintenance of cellular homeostasis. Nicotinamide N-methyltransferase (NNMT) serves as a crucial link between cellular metabolism and epigenetics by catalyzing ni...
Prediction of human pharmacokinetic parameters incorporating SMILES information [0.03%]
结合SMILES信息预测人药动学参数
Jae-Hee Kwon,Ja-Young Han,Minjung Kim et al.
Jae-Hee Kwon et al.
This study aimed to develop a model incorporating natural language processing analysis for the simplified molecular-input line-entry system (SMILES) to predict clearance (CL) and volume of distribution at steady state (Vd,ss) in humans. The...