Multiplex Magnetic Biosensor Microarrays Facilitate Personalized Vaccination Schedules for SARS-CoV-2 Variants [0.03%]
多重磁性生物传感器微阵列可促进SARS-CoV-2变异株的个性化疫苗接种方案
Hyun-Kyung Um,Songeun Kim,Jueun Hwang et al.
Hyun-Kyung Um et al.
Rapid, sensitive, multiplexed antibody detection technologies are essential for assessing vaccine efficacy and recipient immunity against viruses. As severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants continue to emerge a...
CRISPR/Cas-Based Nanobiosensor Using Plasmonic Nanomaterials to Detect Disease Biomarkers [0.03%]
基于等离激元纳米材料的CRISPR / Cas纳米生物传感器用于检测疾病生物标志物
Jin-Ha Choi,Jinho Yoon,Meizi Chen et al.
Jin-Ha Choi et al.
The development of clustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR-associated protein (Cas) technology (CRISPR/Cas) as a gene-editing tool has the potential to revolutionize nucleic acid analysis. Recently, CRI...
Fabrication of Biomimetic Cell Culture Membranes Using Robust and Reusable Nickel Micropillar Molds [0.03%]
使用坚固且可重复使用的镍微柱模具制造仿生细胞培养膜
Taiki Otomo,Hyunsoo Noh,Tatsuya Matsubara et al.
Taiki Otomo et al.
In the practical application of organ-on-a-chip, mass production technology for flexible porous membranes is an essential element for mimicking the basement membrane of the body. Porous PDMS membrane is a promising material due to its high ...
Advanced Organotypic In Vitro Model Systems for Host-Microbial Coculture [0.03%]
用于宿主-微生物共培养的先进器官型体外模型系统
Raehyun Kim
Raehyun Kim
In vitro model systems have been advanced to recapitulate important physiological features of the target organ in vivo more closely than the conventional cell line cultures on a petri dish. The advanced organotypic model systems can be used...
Paper-Based Radial Flow Assay Integrated to Portable Isothermal Amplification Chip Platform for Colorimetric Detection of Target DNA [0.03%]
集成到便携等温扩增芯片平台上的纸基径向流动检测卡用于目标DNA的比色测定
Tai-Yong Kim,Sanha Kim,Jae Hwan Jung et al.
Tai-Yong Kim et al.
A novel integrated detection system that introduces a paper-chip-based molecular detection strategy into a polydimethylsiloxane (PDMS) microchip and temperature control system was developed for on-site colorimetric detection of DNA. For the...
Deep Learning-Assisted Droplet Digital PCR for Quantitative Detection of Human Coronavirus [0.03%]
深度学习辅助的滴定数字PCR用于人类冠状病毒的定量检测
Young Suh Lee,Ji Wook Choi,Taewook Kang et al.
Young Suh Lee et al.
Since coronavirus disease 2019 (COVID-19) pandemic rapidly spread worldwide, there is an urgent demand for accurate and suitable nucleic acid detection technology. Although the conventional threshold-based algorithms have been used for proc...
Pressed Lateral Flow Assay Strips for Flow Delay-Induced Signal Enhancement in Lateral Flow Assay Strips [0.03%]
压延式侧向流动试纸条用于延长流动时间以增强信号强度
Se Been Park,Joong Ho Shin
Se Been Park
This paper proposes that the signal intensity of a lateral flow assay (LFA) strip can be increased by pressing the top of the strip, effectively reducing its flow rate. The reduced flow rate allows more time for antigen-antibody interaction...
Highly Efficient DNA Reporter for CRISPR/Cas12a-Based Specific and Sensitive Biosensor [0.03%]
一种用于CRISPR / Cas12a的高效DNA报告基因的特异性和灵敏度生物传感器
Seungjin Lee,Deahan Nam,Jung Soo Park et al.
Seungjin Lee et al.
In addition to cis-cleavage activity that recognizes and cleaves nucleic acid sequences, a trans-cleavage activity that indiscriminately and non-specifically cleaves single-stranded DNA or RNA has been discovered in some Cas proteins, inclu...
A Lateral Flow Assay for Nucleic Acid Detection Based on Rolling Circle Amplification Using Capture Ligand-Modified Oligonucleotides [0.03%]
一种基于滚环扩增的核酸 lateral flow 试纸条检测法
Ha Neul Lee,Juhee Lee,Yoo Kyung Kang et al.
Ha Neul Lee et al.
We introduce a lateral flow assay (LFA) integrated with a modified isothermal nucleic acid amplification procedure for rapid and simple genetic testing. Padlock probes specific for the target DNA were designed for ligation, followed by roll...
Micro-injection Molded Droplet Generation System for Digital PCR Application [0.03%]
微注射模塑数字PCR应用液滴生成系统
Daae Jo,So Young Kim,Hyeon Woo Kang et al.
Daae Jo et al.
Sensitive, effective, and quantitative analysis of infectious pathogens is an important task for the prevention of human health threats. Herein, we present an advanced approach to producing gene-encapsulated microdroplets for quantitative a...