Analysis of risk factors for infusion-related reactions in patients with B-cell lymphoma during obinutuzumab treatment [0.03%]
奥妥珠单抗治疗B细胞淋巴瘤患者输液相关反应风险因素分析
Zi Wang,Yan Zhang,Danqing Zhao et al.
Zi Wang et al.
This study investigated the risk factors associated with infusion-related reactions (IRRs) in B-cell lymphoma patients receiving obinutuzumab. A retrospective analysis of Peking Union Medical College Hospital patients (January 2021-December...
Real-world evidence for the use of olaparib in pancreatic cancer in Spanish hospitals [0.03%]
奥拉帕利在西班牙医院胰腺癌患者中使用的真实世界证据
Héctor Carlos García-Díaz,Javier Gómez-Alonso,María Teresa Rabuñal-Álvarez et al.
Héctor Carlos García-Díaz et al.
Patients with pancreatic cancer (PC) harboring DNA damage repair genes (DDRg) alterations, particularly BRCA1/2, may benefit from olaparib. Although the phase III POLO trial demonstrated improved progression-free survival (PFS) with olapari...
Intracranial efficacy of systemic therapies for patients with ALK-positive non-small cell lung cancer in patients with brain metastases: a systematic review and meta-analysis [0.03%]
系统治疗对ALK阳性的非小细胞肺癌脑转移患者颅内有效性的系统评价和meta分析
Diego A Hernandez,Gabriela Petersen,Jimena Gonzalez-Salido et al.
Diego A Hernandez et al.
Lung cancer remains the leading cause of cancer-related mortality worldwide. Among patients with advanced non-small cell lung cancer (NSCLC), ALK-positive disease accounts for roughly 5% of cases We conducted a systematic search of PubMed, ...
Cisplatin-based chemotherapy is a possible risk factor for cerebral stroke in patients with testicular germ cell tumour - a case report and review of the literature [0.03%]
以顺铂为基础的化疗可能是睾丸生殖细胞肿瘤患者发生脑卒中的风险因素-一例报告及文献复习
Klaus-Peter Dieckmann,Markus Angerer,Bernd Eckert et al.
Klaus-Peter Dieckmann et al.
Cerebral stroke secondary to cisplatin-based chemotherapy in young patients undergoing chemotherapy for testicular germ cell tumour (GCT) has been reported only sporadically. Here, we report a 49-year-old man undergoing adjuvant chemotherap...
Effectiveness of azacytidine for poly ADP-ribose polymerase inhibitor-induced myelodysplastic syndrome in ovarian cancer patient: a twofold triumph [0.03%]
阿扎胞苷治疗卵巢癌患者PARP抑制剂所致骨髓增生异常综合征的有效性：双重胜利
Stefano Fucina,Riccardo Vida,Arianna Dri et al.
Stefano Fucina et al.
Ovarian cancer is characterised by a high mortality rate. Standard of care treatment is based on upfront debulking surgery followed by platinum-based chemotherapy. Currently, the majority of patients in response to platinum agents could ben...
Nab-paclitaxel for the treatment of cervical cancer: a systematic review of clinical safety and effectiveness [0.03%]
纳米白蛋白结合型紫杉醇治疗宫颈癌的临床安全性和有效性系统评价
I Gusti Ngurah Agung Wiwekananda,Nik Ahmad Nizam Nik Malek,Agustina Tri Endharti et al.
I Gusti Ngurah Agung Wiwekananda et al.
Cervical cancer remains a major global health burden, particularly in advanced and recurrent disease, where therapeutic options are limited. We conducted a systematic review of clinical studies evaluating nab-paclitaxel-based regimens in ce...
Safety analysis of vinorelbine in the real world: a pharmacovigilance study based on the FAERS database [0.03%]
基于FAERS数据库的长春瑞滨安全性的信号检测及分析研究
Yuhui Li,Zheng Shi,Xiaoshuang Fu et al.
Yuhui Li et al.
Vinorelbine is widely used for non-small cell lung cancer, breast cancer, and other solid tumors, yet real-world safety data remain limited. We analyzed adverse events associated with vinorelbine using the FDA Adverse Event Reporting System...
Efficacy and safety of trabectedin and pegylated liposomal doxorubicin in elderly patients: a subgroup analysis of a retrospective cohort [0.03%]
关于曲贝替丁和脂质体多柔比星治疗老年患者的疗效和安全性亚组分析：一项回顾性队列研究
Martina Catalano,Greta Zennaro,Maria Cristina Petrella et al.
Martina Catalano et al.
Elderly patients with recurrent ovarian cancer are often underrepresented in clinical trials, complicating treatment decisions because of comorbidities and altered drug tolerance. Trabectedin plus pegylated liposomal doxorubicin is a non-pl...
Biliary disorders associated with immune checkpoint inhibitors: a pharmacovigilance analysis of the FDA adverse event reporting system (FAERS) database [0.03%]
免疫检查点抑制剂相关胆道损伤的药物警戒分析：来源于美国食品药品管理局不良事件数据库报告
Shiju Wei,Zhenyu Zhang,Xuhua Song et al.
Shiju Wei et al.
Immune checkpoint inhibitors (ICIs) are linked to severe biliary disorders (BDs). Using FAERS data (Q1 2015-Q1 2025), we identified 4,405 BD cases via standardized MedDRA queries (144 preferred terms). ICIs were significantly associated wit...
Efficacy and safety of adjuvant chemotherapy for locally advanced cervical carcinoma: an updated Systematic review and meta-analysis [0.03%]
局部晚期宫颈癌辅助化疗有效性和安全性的系统评价和meta分析更新
Eeshal Fatima,Khawaja Abdul Rehman,Obaid Ur Rehman et al.
Eeshal Fatima et al.
This meta-analysis assessed the latest clinical efficacy and safety of adjuvant chemotherapy (ACT) after concurrent chemoradiotherapy (CCRT) compared to CCRT alone for locally advanced cervical cancer. Studies were pooled via random effects...