Eravacycline in sepsis complicated by Clostridioides difficile infection: a brief case series [0.03%]
埃拉瓦西林治疗由难辨梭状芽孢杆菌感染引起的脓毒症：3例简短报告
Federico Giovagnorio,Giovanni Del Fabro,Agnese Zanus-Fortes et al.
Federico Giovagnorio et al.
Clostridioides difficile infection complicating severe bacterial infections presents a therapeutic challenge, when antimicrobial discontinuation is unfeasible. Eravacycline, a synthetic fluorocycline with broad-spectrum activity against Gra...
Apatinib combined with capecitabine plus temozolomide versus sunitinib in advanced gastroenteropancreatic neuroendocrine tumours: a propensity score-matched real-world study [0.03%]
阿帕替尼联合卡培他滨和替莫唑胺与舒尼替尼治疗晚期胃肠胰神经内分泌肿瘤的疗效：一项倾向评分匹配的真实世界研究
Tiegang Li
Tiegang Li
Apatinib combined with CAPTEM (capecitabine plus temozolomide) has demonstrated preliminary activity in neuroendocrine tumours, yet head-to-head comparative efficacy data against standard-of-care sunitinib remain lacking. This study aims to...
Pharmacokinetic/pharmacodynamic optimization of antimicrobial therapy in neutropenic sepsis: a comprehensive review [0.03%]
抗微生物治疗中性粒细胞减少症合并脓毒血症的药代动力学/药效学优化：全面综述
Bin Qiu,Jianjiang Huang,Fang Zhang et al.
Bin Qiu et al.
Neutropenic sepsis remains a life-threatening complication in patients undergoing cytotoxic chemotherapy or haematopoietic stem cell transplantation. A comprehensive literature search was conducted across PubMed, Embase, and the Cochrane Li...
Cefiderocol for Stenotrophomonas maltophilia infections: real-world evidence from a multicenter study and a comprehensive literature review [0.03%]
头孢狄罗治疗产碱杆菌属感染：多中心研究的真实世界证据及全面文献回顾
Michela Comi,Giulia Mancarella,Silvia Di Bari et al.
Michela Comi et al.
Stenotrophomonas maltophilia is an opportunistic multidrug-resistant pathogen increasingly associated with severe infections. Although cefiderocol has demonstrated potent in-vitro activity against S. maltophilia, clinical evidence remains l...
Cefiderocol susceptibility in carbapenem-resistant Acinetobacter baumannii, Pseudomonas aeruginosa, and Stenotrophomonas maltophilia isolates: concordance of disk diffusion with the reference method and comparative analysis of CLSI-EUCAST criteria [0.03%]
头孢迪罗对碳青霉烯类耐药的产超广谱β-内酰胺酶肠杆菌科细菌、不动杆菌属和铜绿假单胞菌分离株的体外抗菌活性：与参考方法的一致性及CLSI-EUCAST breakpoint折点标准比较分析
Esra Saylam,Betul Cetin,Fatma Kalem et al.
Esra Saylam et al.
This study investigated the in vitro activity of cefiderocol against Acinetobacter baumannii, Pseudomonas aeruginosa, and Stenotrophomonas maltophilia isolates, comparing disk diffusion (DD) and broth microdilution (BMD) methods. 145 isolat...
High-dose continuous infusion of piperacillin/tazobactam via elastomeric pump in a pediatric patient with Kartagener syndrome: pharmacokinetic target attainment and clinical outcome [0.03%]
卡塔格内综合征患儿使用piperacillin/tazobactam高剂量连续输注的药代动力学指标及临床疗效分析
Marcello Mariani,Sandro Dallorso,Vera Morsellino et al.
Marcello Mariani et al.
Multidrug-resistant Achromobacter xylosoxidans infections in pediatric patients with primary ciliary dyskinesia (PCD) often require prolonged intravenous therapy. We evaluated the pharmacokinetics of continuous infusion piperacillin/tazobac...
Immunotherapeutic strategies in gastroenteropancreatic neuroendocrine neoplasms: present condition and future developments [0.03%]
胃肠胰神经内分泌肿瘤免疫治疗现状及未来展望
Durlav Chowdhury,Arunava Mishra,Maikala Muskan Rao et al.
Durlav Chowdhury et al.
Gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) are heterogeneous malignancies frequently resistant to standard therapies. Immunotherapy represents a novel management frontier. This review synthesises clinical and translational e...
Oritavancin as sequential therapy for vancomycin-resistant Enterococcus faecium prosthetic valve endocarditis: a case report [0.03%]
厄他培南作为耐万古霉素粪肠球菌生物人工心脏瓣膜感染序贯治疗的病例报告
Christina Petropoulou,George Eleftherakis,Alexandros Tousis et al.
Christina Petropoulou et al.
We report the case of a 91-year-old man with prosthetic valve endocarditis (PVE) caused by vancomycin-resistant Enterococcus faecium (VRE), successfully managed with an initial two-week course of intravenous daptomycin and fosfomycin, follo...
The impact of low-volume hydration on kidney function in low-dose cisplatin therapy for biliary tract cancer: a multicentre retrospective cohort study [0.03%]
小剂量顺铂治疗胆道癌时低容输液对肾功能影响的多中心回顾性队列研究
Hiroyuki Watanabe,Katsuya Makihara,Masahiko Nakao et al.
Hiroyuki Watanabe et al.
Hydration is crucial for preventing cisplatin-induced nephrotoxicity; however, optimal hydration for low-dose cisplatin (
Evaluating eravacycline dosing regimens in the treatment of SSTIs caused by carbapenem-resistant Enterobacteriaceae in adults: a pharmacokinetic/pharmacodynamic analysis using Monte Carlo simulation [0.03%]
成人治疗由碳青霉烯耐药肠杆菌科细菌引起的皮肤和软组织感染的埃拉瓦星剂量方案评估：使用蒙特卡洛模拟的药物代谢动力学/药物效应动力学分析
Xiang-Jun Yang,Xiao-Chen Wei,Hai-Rong Lyu et al.
Xiang-Jun Yang et al.
This study aimed to assess the efficacy of different eravacycline regimens for adult skin and soft-tissue infections (SSTIs) caused by carbapenem-resistant Enterobacteriaceae (CRE). Monte Carlo simulations were performed using pharmacokinet...