Successful remdesivir treatment of coronavirus OC43 pneumonia in a lung transplant recipient [0.03%]
成功利用瑞德西韦治疗一名肺移植受者患上的冠状病毒OC43肺炎
Raffaella Gallo,Lorenzo Bertolino,Fabian Patauner et al.
Raffaella Gallo et al.
Lung transplantation is a well-established treatment for end-stage lung disease. Viral infections represent major infective complications after lung transplantation. Respiratory viruses can increase immune responses and the development of a...
Efficacy and safety of trastuzumab deruxtecan in HER2-high and HER2-low breast cancer: a systematic review and meta-analysis of randomized controlled trials [0.03%]
抗HER2高表达及低表达阳性晚期乳腺癌疗效与安全性：德喜曲妥珠单抗的系统评价和网状Meta分析
Sheng-Yen Hsiao,Wei-Ting Lin,Cheng-Yao Lin et al.
Sheng-Yen Hsiao et al.
Breast cancer is the most common malignancy, with approximately ∼20% of cases involving HER2 overexpression. Trastuzumab deruxtecan (T-DXd), an HER2-targeted antibody-drug conjugate, is approved for HER2-high and HER2-low disease. This met...
Novel SNX25-ROS1 fusion mutation confers therapeutic sensitivity to entrectinib: a case report and literature review [0.03%]
新型SNX25-ROS1融合突变对恩曲替尼敏感性病例报道及文献复习
Qian Liu,Mingqin Wei,Youhong Dong et al.
Qian Liu et al.
ROS1 gene fusions are oncogenic driver in 1-2% non-small cell lung cancer (NSCLC). This report presents the first case of a novel SNX25-ROS1 fusion mutation in a 56-year-old female with lung adenocacinoma, presenting with headaches and beha...
USP54 suppresses bladder cancer proliferation, stemness, and cisplatin resistance via deubiquitination-mediated stabilization of SIRT6 [0.03%]
去泛素化介导的SIRT6稳定化抑制USP54膀胱癌增殖，肿瘤干细胞特性及顺铂耐药性
Yinan Han,Shengxing Wang,Rurui Xia et al.
Yinan Han et al.
Bladder cancer is a prevalent and lethal malignancy worldwide, with treatment options often limited by the development of chemoresistance, especially to cisplatin-based regimens. In this study, we identified ubiquitin-specific protease 54 (...
Regorafenib in adult patients with recurrent glioblastoma: a single-arm meta-analysis [0.03%]
瑞戈非尼治疗成人复发胶质母细胞瘤的单臂meta分析研究
Marcos Henrique da Silva Mezzari,Natan Lucca Lima,Bárbara Ghizoni Maggi et al.
Marcos Henrique da Silva Mezzari et al.
Glioblastoma is an aggressive brain tumor with median survival under 2 years despite standard therapy. At recurrence, treatment options are limited, and regorafenib has emerged as a promising option. A systematic search was conducted throug...
Genetic landscape and therapeutic evolution of cyclophosphamide: spotlight on breast cancer [0.03%]
环磷酰胺的基因组谱系和治疗演变：聚焦于乳腺癌研究
Jiaoyan Cao,Xin Xu,Tao Lu et al.
Jiaoyan Cao et al.
Cyclophosphamide is a chemotherapeutic agent widely used in breast cancer management. As a prodrug, its therapeutic efficacy and toxicity are profoundly influenced by host genetic variations that govern its metabolism, detoxification, DNA r...
RACGAP1 promotes the malignant phenotype and cisplatin resistance of nasopharyngeal carcinoma cells by upregulating HIF-1α [0.03%]
RACGAP1通过上调HIF-1α促进鼻咽癌细胞恶性表型和顺铂耐药性
Jiadi Dong,Yanghao Hu,Jingjing Chen et al.
Jiadi Dong et al.
Nasopharyngeal carcinoma (NPC) is a radiosensitive malignancy, but chemotherapy resistance remains a major challenge. This study investigated the role of RACGAP1, a GTPase regulator often overexpressed in cancers, in NPC progression and che...
Furmonertinib activity in NSCLC Harbouring EGFR L858R and ERBB2 S310F co-mutations: a case report with literature review [0.03%]
艾伏美替尼对EGFR L858R和ERBB2 S310F共突变非小细胞肺癌的疗效：一例报告及文献复习
Shiyue Liu,Runze Cao,Hong Li et al.
Shiyue Liu et al.
While targeted therapies have remarkably transformed the landscape of lung adenocarcinoma (LUAD) management, the clinical implications of concurrent mutations in EGFR and ERBB2 remain inadequately understood due to their exceptional rarity ...
Recent advances in polymer-based nanoparticles: current strategies and translational challenges in cancer therapy [0.03%]
基于聚合物的纳米颗粒近期在癌症治疗方面的进展：目前策略和转化挑战
Kumar Janakiraman,Vaidevi Sethuraman,Venkateshwaran Krishnaswami et al.
Kumar Janakiraman et al.
Polymer-based nanoparticles (PNPs) are emerging as a cornerstone in cancer therapy due to their ability to enhance drug solubility, improve pharmacokinetics and achieve precise tumor targeting. Nanoparticles, encompassing liposomes, dendrim...
Rethinking antibiotic use in hidradenitis suppurativa: a call for stewardship [0.03%]
重新思考汗腺炎中抗生素的使用：倡导管理规范
E Rosi,G Silvi,A Di Cesare et al.
E Rosi et al.