Effective treatment of a highly active antiretroviral regimen through jejunostomy [0.03%]
空肠给药高效抗逆转录病毒疗法成功治疗一名患者
Marta Florit-Sureda,Maria Giner-Soriano,Javier Mateu-de Antonio et al.
Marta Florit-Sureda et al.
A 49-year-old woman voluntarily not receiving HIV treatment was admitted to the emergency department showing sepsis and peritonism. She required several surgical procedures for intestinal perforations. Finally, a proximal-terminal jejunosto...
Activity of the colistin-rifampicin combination against colistin-resistant, carbapenemase-producing Gram-negative bacteria [0.03%]
多粘菌素-利福平联合应用对多粘菌素耐药的碳青霉烯酶产生革兰阴性细菌的作用
Marcela Nastro,Carlos Hernan Rodríguez,Renata Monge et al.
Marcela Nastro et al.
Colistin (COL) is one of the few antimicrobials that retain activity against carbapenemase-producing Gram-negative bacteria (GNB). However, the emergence of COL resistance has renewed the use of combination therapy. The aim of this study wa...
Molecular epidemiology and mechanisms of antimicrobial resistance in Pseudomonas aeruginosa isolates causing burn wound infection in Iran [0.03%]
伊朗烧伤创面感染铜绿假单胞菌的分子流行病学和耐药机制研究
Hossein Fazeli,Hooman Sadighian,Bahram Nasr Esfahani et al.
Hossein Fazeli et al.
In this study, the contributions of different resistance mechanisms in Pseudomonas aeruginosa isolates were investigated among burned patients. The real-time reverse transcription polymerase chain reaction was performed to determine the exp...
Molecular characterization of Rifr mutations in Enterococcus faecalis and Enterococcus faecium [0.03%]
屎肠球菌和粪肠球菌中Rifr基因突变的分子特征分析
Xiaoxing Du,Xiaoting Hua,Tingting Qu et al.
Xiaoxing Du et al.
Mutation rate is an important factor affecting the appearance and spread of acquired antibiotic resistance. The frequencies and types of enterococci mutations were determined in this study. The MICs of rifampicin in enterococci and their ri...
A novel ruthenium(II)-polypyridyl complex inhibits cell proliferation and induces cell apoptosis by impairing DNA damage repair [0.03%]
一种新型钌(ii)多吡啶配合物通过破坏dna修复抑制细胞增殖并诱导凋亡
Qingyuan Yang,Zhao Zhang,Wenjie Mei et al.
Qingyuan Yang et al.
Ruthenium complexes are widely recognized as one of the most promising DNA damaging chemotherapeutic drugs. The main goal of this study was to explore the anticancer activity and underlying mechanisms of [Ru(phen)(2)(p-BrPIP)](ClO(4))(2), a...
A phase II FOLFOX-4 regimen as second-line treatment in advanced biliary tract cancer refractory to gemcitabine/cisplatin [0.03%]
吉西他滨/顺铂治疗失败的胆道癌晚期患者的第二线FOLFOX-4方案治疗试验（II期）
Shengli He,Jie Shen,Xianjun Sun et al.
Shengli He et al.
Objective: We aimed to evaluate the efficacy and safety of oxaliplatin, 5-fluorouracil (5-FU), and leucovorin (LV) (FOLFOX-4) as second-line treatment in patients with advanced biliary tract cancer (BTC) failing gemcitabi...
The Pan European Emesis Registry (PEER): a critical appraisal of the Italian experience [0.03%]
欧洲泛区域呕吐登记处（PEER）：对意大利经验的批判性评估
Davide Pastorelli,Maria Adelia Locatelli,Barbara Melotti et al.
Davide Pastorelli et al.
Purpose: Data from a large European prospective observational study were analysed to describe the antiemetic prescribing pattern for chemotherapy-induced nausea and vomiting (CINV) in Italian clinical practice. ...
Observational Study
Journal of chemotherapy (Florence, Italy). 2013 Oct;25(5):309-17. DOI:10.1179/1973947813Y.0000000118 2013
Isogambogenic acid inhibits tumour angiogenesis by suppressing Rho GTPases and vascular endothelial growth factor receptor 2 signalling pathway [0.03%]
异甘博基酸通过抑制Rho小G蛋白和血管内皮生长因子受体2信号通路来抑制肿瘤新生血管生成
Yi Fan,Aihua Peng,Shichao He et al.
Yi Fan et al.
Isogambogenic acid (iso-GNA) is a well-known herbal medicine extracted from Garcinia hanburyi. Although it is thought to have anti-tumour effects, its function is still unknown. This study carried out in vitro and in vivo evaluations of the...
Anticancer activity of an antisense oligonucleotide targeting TRADD combined with proteasome inhibitors in chemoresistant hepatocellular carcinoma cells [0.03%]
针对TRADD的反义寡核苷酸联合蛋白酶体抑制剂在化疗耐药肝癌细胞中的抗肿瘤活性
Ewa Witort,Matteo Lulli,Vinicio Carloni et al.
Ewa Witort et al.
Chemoresistance is a major cause of mortality of patients with advanced and metastatic hepatocellular carcinoma (HCC), the fifth most common cancer in the world. We employed a molecular approach to inhibit cell proliferation and induce apop...
Can low-dose preemptive valganciclovir replace standard intravenous ganciclovir treatment in recipients of allogeneic stem cell transplantation? [0.03%]
低剂量的バルシクリバール能否替代allo-HSCT受者常规应用的静脉诱导性加替沙星治疗？
Leylagül Kaynar,Gökhan Metan,Selma Gökahmetoğlu et al.
Leylagül Kaynar et al.
The aim of this retrospective study was to compare the efficacy and safety of standard intravenous ganciclovir (GCV) with low-dose oral valganciclovir (VGC) in preemptive treatment of cytomegalovirus (CMV) infection in patients who received...