Real-world effectiveness and safety of meropenem-vaborbactam in the treatment of carbapenem-resistant enterobacterales (CRE) infections: a systematic review and meta-analysis [0.03%]
美罗培南-瓦博巴克特在治疗碳青霉烯耐药肠杆菌感染中的真实世界有效性和安全性：系统回顾和荟萃分析
Dongcai Jin,Danyang Hu,Yuhong Jin
Dongcai Jin
This study aimed to evaluate the effectiveness and safety of Meropenem-Vaborbactam(M-V) for treating carbapenem-resistant Enterobacterales (CRE) infections based on real-world data. A systematic search of PubMed, Embase, Cochrane Library, a...
Piperacillin/Tazobactam is associated with a higher risk of acute kidney injury compared to cefepime and meropenem [0.03%]
相比头孢哌酮和美罗培南，哌拉西林他唑巴坦更易引起急性肾损伤
Nami Obara,Toshiaki Komatsu,Kazuyoshi Shiratsu et al.
Nami Obara et al.
This retrospective study investigated whether piperacillin/tazobactam (PIPC/TAZ) monotherapy affects renal function compared to cefepime (CFPM) or meropenem (MEPM) monotherapy. Hospitalized patients who received PIPC/TAZ, CFPM, or MEPM mono...
Therapeutic drug monitoring-guided high-dose isavuconazole therapy for invasive pulmonary aspergillosis in a patient on extracorporeal membrane oxygenation support [0.03%]
体外膜氧合支持下治疗侵袭性肺曲霉病的高剂量艾沙康唑血药浓度指导给药疗法
Alba Pau-Parra,Manuel Sosa Garay,Laura Doménech Moral et al.
Alba Pau-Parra et al.
We review the case of a 58-year-old female on extracorporeal membrane oxygenation (ECMO) support diagnosed with invasive pulmonary aspergillosis (IPA). Intravenous isavuconazole was started, requiring dose escalation to achieve isavuconazol...
Immune-related adverse events not associated with survival in advanced or metastatic gastroesophageal cancers [0.03%]
免疫相关不良事件与晚期或转移性胃食管癌患者的生存无关
Omar Elghawy,Reema Patel,Abhishek Mullapudi et al.
Omar Elghawy et al.
Immune checkpoint inhibitors (ICIs) have shown promise in the treatment of gastric and oesophageal cancers (GEC). Despite their promising efficacy, ICIs have been associated with unique side effects known as immune-related adverse events (I...
An acquired CCDC6:: RET gene fusion as resistance mechanism for Osimertinib in exon 21 EGFR(L858R)-mutated non-small cell lung cancer and its successful management with Osimertinib and Selpercatinib: a case report and review of literature [0.03%]
非小细胞肺癌患者接受奥希替尼治疗后因CCDC6::RET融合突变产生耐药及其联合奥希替尼和塞尔帕替尼成功克服耐药的病例报告及文献回顾（L858R突变）
Maud Lormans,Peter Van Haecke,Ingel Demedts
Maud Lormans
Background: Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKI) are the recommended front-line therapy for treatment-naïve patients with advanced stage EGFR mutated Non-Small Cell Lung Cancer (NSCLC), with better toleran...
Assessment of in vitro interactions between delafloxacin and other antimicrobials against multi-drug resistant Pseudomonas aeruginosa strains [0.03%]
德拉沙星与其他抗菌药物对多重耐药铜绿假单胞菌株的体外相互作用评估
Emel Mataracı Kara,Selin Melis Çakmak,Sevda Er
Emel Mataracı Kara
Novel therapeutic interventions are required to address the critical antimicrobial resistance caused by multidrug-resistant Pseudomonas aeruginosa (MDR-PA) infections. This study examines the impact of combining delafloxacin with antibiotic...
Durlav Chowdhury,Ashmita Das,Mrityunjay Mishra et al.
Durlav Chowdhury et al.
Immunotherapy has been advanced through multiple approaches, including immunogenic cytokines, monoclonal antibodies, therapeutic vaccinations, adoptive cell transfer, stem cell transplantation, and oncolytic viruses. This review analyses va...
Optimizing the dosing regimens of linezolid against gram-positive cocci in critically ill patients with different renal functions: a Monte Carlo simulation [0.03%]
Monte Carlo模拟优化利奈唑胺在不同程度肾功能危重患者中治疗革兰氏阳性球菌的给药剂量方案
Hongyu Qiu,Hao Li,Lingti Kong
Hongyu Qiu
To promote the accurate administration of linezolid, this study aimed to evaluate its dosage regimens in critically ill patients with varying renal functions. This evaluation was based on a combined analysis of pharmacokinetic (PK), pharmac...
Bilha Baby,Nevin Sam,Narmadha M P et al.
Bilha Baby et al.
Anti-tumor drugs cause hand-foot syndrome through a variety of pathogenic mechanisms. Some chemotherapeutic medications that can cause HFS include 5FU, doxorubicin, capecitabine, high dose cytarabine, and others. These medications each have...
The acceleration of cisplatin resistance in colorectal cancer by lncRNA NORAD through regulation of miR-106a-5p/Cyclin D1 axis [0.03%]
长链非编码RNA NORAD通过调节miR-106a-5p/Cyclin D1轴加速顺铂耐药在结直肠癌中的作用
Liping Guo,Xianmei Li,Yujuan Kang et al.
Liping Guo et al.
Colorectal cancer (CRC) is one of the leading causes of cancer-related mortality. LncRNA NORAD is frequently upregulated and positively associated with various cancer progressions. We discovered NORAD was significantly upregulated in CRC ti...