Colorectal cancer in south sulawesi: a case-control study for nongenetic risk factors [0.03%]
南苏拉威西的结直肠癌：非遗传危险因素病例对照研究
Upik A Miskad,Matthew Martianus Henry,Carissa Ikka Pardamean et al.
Upik A Miskad et al.
Background: This study analyzed the nongenetic risk factors that contributed to colorectal cancer (CRC) incidence in the South Sulawesi population through a case-control study. ...
A brief review of Lynch syndrome: understanding the dual cancer risk between endometrial and colorectal cancer [0.03%]
林奇综合征简述：理解子宫内膜癌和结直肠癌的双重致癌风险
Sneha Pallatt,Sibin Nambidi,Subhamay Adhikary et al.
Sneha Pallatt et al.
Lynch syndrome (LS) is an autosomal dominant disorder caused by germline mutations in DNA mismatch repair (MMR) genes. These mutations result in frameshift alterations, leading to the accumulation of errors within microsatellites. Individua...
Elham Babadi,Kamran Roudini,Kianmehr Aalipour et al.
Elham Babadi et al.
Colorectal cancer is a leading cause of cancer related deaths among patients worldwide, necessitating the development of more effective and tolerable therapies. Topoisomerase I inhibitors such as Irinotecan are integral components of chemot...
Targeting mitochondrial ClpP: structural insights and therapeutic potential of ClpP agonists in cancer therapy [0.03%]
靶向线粒体ClpP：ClpP激动剂在癌症治疗中的结构见解和潜在疗效
Mowei Kong,Yang Yu,Shuai Shao et al.
Mowei Kong et al.
Mitochondrial "powerhouses" play a central function in cellular metabolism and energy generation. Their dysregulation is directly correlated with a myriad of diseases, among them cancer. The serine protease ClpP, accompanied by its cochaper...
Efficacies of radiotherapy in rectal cancer patients treated with total mesorectal excision or other types of surgery: an updated meta-analysis [0.03%]
全直肠系膜切除术等手术治疗的直肠癌患者放射治疗的有效性：一项荟萃分析的更新结果
Wenshu Wang,Runyuan Zhao,Xi Liang et al.
Wenshu Wang et al.
Background: An updated meta-analysis was conducted to evaluate the efficacy of radiotherapy in rectal cancer patients treated with total mesorectal excision (TME) or other types of surgery (non-TME-only). ...
Saskia Hazout,Christoph Oehler,Daniel R Zwahlen et al.
Saskia Hazout et al.
Introduction: Since Röntgen's discovery of X-rays in 1895, advancements in radiobiology have significantly shaped radiotherapy practices. This historical review traces the evolution of radiobiological theories and their ...
The endocannabinoid system in cancer biology: a mini-review of mechanisms and therapeutic potential [0.03%]
癌生物学中的内源大麻素系统：机制和治疗潜力的简评
Kaio Cezar Rodrigues Salum,Gabriel Brendo Alves Miranda,Alessandra Lima Dias et al.
Kaio Cezar Rodrigues Salum et al.
The Endocannabinoid System (ECS) plays a critical role in maintaining physiological homeostasis, influencing a range of processes such as neuroprotection, inflammation, energy metabolism, and immune responses. Comprising cannabinoid recepto...
Prospects of engineered bacteria-assisted CAR T Cell therapy in gastrointestinal cancers [0.03%]
工程菌辅助的CAR-T细胞治疗胃肠肿瘤展望
Qingqing Zhang,Xiao Song,Junhong Liu et al.
Qingqing Zhang et al.
The high incidence and mortality rates associated with gastrointestinal cancers represent a significant global health challenge. In recent years, CAR T cell therapy has emerged as a promising immunotherapeutic approach, demonstrating favora...
Treating ER-positive breast cancer: a review of the current FDA-approved SERMs and SERDs and their mechanisms of action [0.03%]
治疗ER阳性乳腺癌：目前FDA批准的SERM和SERD及其作用机制综述
Nayoung Kim,Kiven Erique Lukong
Nayoung Kim
Breast cancer is one of the most significant causes of mortality among women and the second most prevalent cancer worldwide. Estrogen receptor (ER)-positive breast cancers are the most common molecular subtype of breast cancer, comprising a...
Advancements and challenges in personalized neoantigen-based cancer vaccines [0.03%]
个性化新抗原癌症疫苗的进展与挑战
Parminder Singh,Mahalaqua Nazli Khatib,Roopashree R et al.
Parminder Singh et al.
Advancements in personalized neoantigen-based cancer vaccines are ushering in a new era in oncology, targeting unique genetic alterations within tumors to enhance treatment precision and efficacy. Neoantigens, specific to cancer cells and a...