Occult squamous cell carcinoma presenting as oligometastatic lymphadenopathy. A systematic review with a case report [0.03%]
隐形鳞状细胞癌继发寡转移性淋巴结病——系统回顾与一例报告
Łukasz Ważny,Jakub Ciesielka,Krzysztof Jakimów et al.
Łukasz Ważny et al.
Background: An occult squamous cell carcinoma (SCC) is a rare subtype of SCC for which standard radiological protocols are often unable to identify the primary tumour. We describe our patient's history and provide a syste...
Recurrent retroperitoneal sarcoma: beyond resectability toward a biology-based therapeutic framework [0.03%]
复发性腹膜后肉瘤：从不可手术切除到基于生物学的治疗框架
Dorian Yarih Garcia-Ortega,Montiel Jiménez Fuertes,Sergio Damian Quildrian et al.
Dorian Yarih Garcia-Ortega et al.
Recurrent retroperitoneal sarcoma remains a significant therapeutic challenge. Recurrence does not always indicate treatment failure but reflects different tumor biologies with diverse implications for local and systemic management. This re...
Achuth Padmanabhan,Shailendra Dwivedi,Melissa A Merritt et al.
Achuth Padmanabhan et al.
Biological models aim to recapitulate the molecular and histologic characteristics, as well as the carcinogenesis of the disease of interest, to enable high-fidelity experimentation and impactful translational development. In high-grade ser...
PSMA-targeted radioligand therapy in advanced prostate cancer: a narrative review of ^177Lu-PSMA, emerging ^225Ac-PSMA strategies, and therapeutic sequencing [0.03%]
针对前列腺癌的PSMA靶向放射配体治疗：关于¹⁷⁷Lu-PSMA、新兴的²²⁵Ac-PSMA策略和治疗顺序的叙述性综述
Natalia Gierulska,Nina Jankowska,Adrianna Kwiatkowska et al.
Natalia Gierulska et al.
Prostate cancer remains a leading cause of cancer-related morbidity and mortality among men, and metastatic castration-resistant prostate cancer continues to present substantial therapeutic challenges despite advances in androgen receptor p...
Salivary cell-free DNA in head and neck cancer: emerging clinical applications and future perspectives [0.03%]
头颈部肿瘤中唾液无细胞DNA的临床应用及未来展望
Vaishnavi N Patel,Aditi B Patel,Shreya A Lotia et al.
Vaishnavi N Patel et al.
Head and neck cancer (HNC) diagnosis and surveillance still rely primarily on clinical examination, imaging, and tissue biopsy, with no established non-invasive biomarkers for routine early detection or disease monitoring. This limitation u...
Targeting glucocorticoid receptor signaling in platinum-resistant ovarian cancer: translational rationale and clinical advances following the ROSELLA trial [0.03%]
ROSELLA试验后铂耐药性卵巢癌糖皮质激素受体信号转导的靶向治疗：转化依据和临床进展
Wenxiang Wang,Zhanghuan Li,Junjie Zhao et al.
Wenxiang Wang et al.
Platinum-resistant ovarian cancer (PROC) remains a major clinical challenge, with limited effective treatment options and poor survival outcomes. Aberrant activation of the glucocorticoid receptor (GR) signaling pathway promotes tumor progr...
Comparative efficacy of subsequent-line therapies for advanced triple-negative breast cancer: a bayesian network meta-analysis [0.03%]
三阴性乳腺癌后续治疗疗效的网状meta分析研究
Zheng Xu,Linxian Ding,Tai Zhao et al.
Zheng Xu et al.
Background: Direct head-to-head randomized comparisons among emerging therapies are limited, making it difficult to determine the optimal subsequent-line treatment for advanced triple-negative breast cancer (TNBC). This s...
Targeting notch signaling pathway in esophageal cancer: from molecular insights to therapies [0.03%]
靶向调控食管癌中的Notch信号通路：从分子机理到临床治疗
Sangita Bhattacharyya,Hindole Ghosh,Ameer Hamza et al.
Sangita Bhattacharyya et al.
Esophageal cancer (EC) is a major digestive cancer with a poor 5-year survival rate of less than 20%. EC incidence is projected to increase by 35% in the US by 2025. The two subtypes of EC with distinct histology, esophageal squamous cell c...
Autophagy in thyroid cancer: stage-dependent switch, mutation-specific regulation, and therapeutic targeting [0.03%]
甲状腺癌中的自噬：阶段依赖性转换、突变特异性调节和治疗靶向
Lihua Fang,Chaowen Wu,Huimin Sun et al.
Lihua Fang et al.
Autophagy plays context-dependent roles in thyroid cancer, but whether its dual nature represents a reversible balance or an irreversible stage-dependent switch has remained unclear. This review synthesizes evidence across papillary, follic...
Nature-based physical activity in breast cancer survivors: a new frontier in supportive care [0.03%]
基于自然的体育活动在乳腺癌幸存者中的应用：支持性护理的新前沿领域
Giuditta Carretti,Mirko Manetti,Mirca Marini
Giuditta Carretti
Breast cancer (BC) survivors frequently experience long-term physical and psychosocial sequelae following treatment, including cancer-related fatigue, cardiovascular dysfunction, sarcopenia, sleep disturbances, and emotional distress, which...