Protecting organs-at-risk in cancer therapies through temporary organ displacement: a comprehensive review [0.03%]
癌症治疗中通过暂时移位保护高危器官的全面综述
Rance B Tino,Michael Li,Amirreza Heshmat et al.
Rance B Tino et al.
Radiation therapy (RT) and locoregional ablation are cornerstones of modern oncology, yet their therapeutic potential is frequently limited by the challenge of sparing healthy organs-at-risk (OARs) from treatment-related complications. Temp...
Non-coding RNAs as novel biomarkers and therapeutic targets in breast cancer [0.03%]
非编码RNA在乳腺癌中的生物标志物和治疗靶点作用的新兴概念
Veronica Barbi,Sara De Martino,Aurora Aiello et al.
Veronica Barbi et al.
Breast cancer (BC) remains a leading cause of cancer-related morbidity and mortality worldwide. Its marked heterogeneity - encompassing molecular subtypes, histological characteristics, and variable therapeutic responses - continues to pose...
Radiation-induced intestinal injury: from molecular mechanisms to clinical translation [0.03%]
辐射诱导的肠损伤：从中分子机制到临床转化
Wenjue Wu,Yubo Cai,Zhi Yang et al.
Wenjue Wu et al.
Radiation-induced intestinal injury (RIII) poses a significant clinical challenge for patients undergoing pelvic or abdominal radiotherapy, characterized by dual features of acute symptoms (diarrhea, abdominal pain, rectal bleeding) and chr...
Janus kinase inhibitors - a role for the treatment of cutaneous T-cell lymphomas? [0.03%]
Janus激酶抑制剂在皮肤T细胞淋巴瘤治疗中的作用？
Sarah E Packer,Patrick M Brunner
Sarah E Packer
Despite increases in prevalence, many cutaneous T-cell lymphoma (CTCL) patients still lack effective and safe therapies for their disease. The most prevalent subtype, mycosis fungoides is usually managed with skin directed treatments in ear...
METTL1 in human cancers: recognition of their functions, mechanisms and therapeutic value [0.03%]
METTL1在人类癌症中的作用：功能、机制及治疗价值的认识
Xinyu Zhang,Yuan Chen,Min Li et al.
Xinyu Zhang et al.
Methyltransferase-like 1 (METTL1) is a methyltransferase that modulates the RNA methylation process and has been increasingly investigated in cancer research over the past decade. The review aims to summarize the diverse roles of METTL1 in ...
Triplet systemic therapy for hormone-sensitive prostate cancer: a critical review with a multidisciplinary approach [0.03%]
激素敏感型前列腺癌的三联系统疗法：采用多学科方法进行批判性回顾
Almudena Zapatero,Teresa Alonso-Gordoa,Alfredo Rodríguez Antolín et al.
Almudena Zapatero et al.
This article aims to critically evaluate the evidence for triplet therapy consisting of androgen deprivation therapy (ADT), docetaxel and a second-generation androgen receptor pathway inhibitor ([ARPI]; abiraterone, enzalutamide, darolutami...
Genetic counseling for hereditary cancer syndromes: a 5-year experience from a single center in Bulgaria [0.03%]
保加利亚一家医学中心5年来的遗传性癌症综合征的遗传咨询经验
Mari Hachmeriyan,Mariya Levkova,Dinnar Yahya et al.
Mari Hachmeriyan et al.
This study presents a 5-year retrospective analysis of genetic counseling (GC) services for hereditary cancer syndromes (HCS) at a single center in Bulgaria. The aim is to describe the demographic and epidemiological characteristics of pati...
Xiaoyi Yan,Hui Ding,Mengxiao Ren et al.
Xiaoyi Yan et al.
This review aims to explore the mechanisms by which mitophagy contributes to treatment resistance in solid tumors. As advancements in cancer therapies continue to evolve, treatment resistance emerges as a significant barrier to successful t...
Fibroblast activation protein and the tumour microenvironment: challenges and therapeutic opportunities [0.03%]
纤维活化蛋白与肿瘤微环境：挑战和治疗机会
Hsing Hwa Lee,Zeyad Al-Ogaili
Hsing Hwa Lee
Fibroblast Activation Protein (FAP) has emerged as a critical player in cancer biology, particularly in shaping the tumour microenvironment (TME) and influencing immunotherapy outcomes. FAP-positive cancer-associated fibroblasts (CAFs) play...
The role and research progress of the MET signalling pathway in targeted therapy for osteosarcoma [0.03%]
MET信号通路在骨肉瘤靶向治疗中的作用及研究进展
Qilong Su,Jingyu Hou,Xinhui Du et al.
Qilong Su et al.
MET, a receptor tyrosine kinase proto-oncogene and the specific receptor for hepatocyte growth factor (HGF), plays a critical role in the initiation and progression of osteosarcoma (OS) through sustained pathway activation. Aberrant activat...