Management of neuroblastoma: a study of first- and second-line chemotherapy responses, a single institution experience [0.03%]
神经母细胞瘤的治疗：一项单中心关于一、二线化疗反应的研究
Emmad E Habib,Amr T El-Kashef,Ezzat S Fahmy
Emmad E Habib
Neuroblastoma is a high-grade malignancy of childhood. It is chemo- and radio-sensitive but prone to relapse after initial remission. The aim of the current study was to study the results of the first- and second-line chemotherapy on the sh...
Theofilou Paraskevi
Theofilou Paraskevi
Health-related quality of life is now considered an important endpoint in cancer clinical trials. It has been shown that assessing quality of life in cancer patients could contribute to improved treatment and could even serve as a prognosti...
Keechilat Pavithran,Shripad Brahmanand Pande
Keechilat Pavithran
The reports of a unique mutation in the Janus kinase-2 gene (JAK2) in polycythemia vera by several independent groups in 2005 quickly spurred the development of the Janus kinase inhibitors. In one of the great victories of translational res...
Thales Paulo Batista,Mário Rino Martins
Thales Paulo Batista
Gastric cancer is one of the most common neoplasms and an important cause of cancer-related death worldwide. Efforts to reduce its high mortality rates are currently focused on multidisciplinary management. However, surgery remains a corner...
Emiel Beijer,Janna Schoenmakers,Guy Vijgen et al.
Emiel Beijer et al.
Until a few years ago, adult humans were not thought to have brown adipose tissue (BAT). Now, this is a rapidly evolving field of research with perspectives in metabolic syndromes such as obesity and new therapies targeting its bio-energeti...
A review of penile metastasis [0.03%]
阴茎转移瘤评论
Luigi Mearini,Renato Colella,Alessandro Zucchi et al.
Luigi Mearini et al.
Penile cancer as primary disease is relatively rare in developed countries. The penis is a rare site of metastases in spite of its rich vascularization. Approximately 500 cases have been reported in the literature; almost 70% of primary les...
Fabiola Paiar,Vanessa Di Cataldo,Giacomo Zei et al.
Fabiola Paiar et al.
Nasopharyngeal carcinoma (NPC) is a unique malignant head and neck cancer with clinical, demographic, and geographic features distinct from other head and neck epithelial malignancies. Non-keratinizing, poorly differentiated, and undifferen...
Can we develop effective combination antiangiogenic therapy for patients with hepatocellular carcinoma? [0.03%]
我们能开发出有效的抗血管生成联合疗法以治疗肝细胞癌患者吗？
Justin B Wenger,Napoleon Santos,Yanxia Liu et al.
Justin B Wenger et al.
Antiangiogenic therapy has shown promise in the treatment of patients with hepatocellular carcinoma (HCC). Bevacizumab, sorafenib, and sunitinib showed efficacy in patients with HCC; and sorafenib is approved by the FDA for treatment of thi...
A limited Review of Over Diagnosis Methods and Long Term Effects in Breast Cancer Screening [0.03%]
乳腺癌筛查中过度诊断方法及长期影响的综述性研究
Dongfeng Wu,Adriana Pérez
Dongfeng Wu
Breast cancer screening programs have been effective in detecting tumors prior to symptoms. Recently, there has been concern over the issue of over-diagnosis, that is, diagnosis of a breast cancer that does not manifest prior to death. Esti...
Metastatic breast cancer cells in the bone marrow microenvironment: novel insights into oncoprotection [0.03%]
骨髓微环境中的乳腺癌转移细胞：新的肿瘤保护机制研究视角
Shyam A Patel,Meneka A Dave,Raghav G Murthy et al.
Shyam A Patel et al.
Among all cancers, malignancies of the breast are the second leading cause of cancer death in the United States after carcinoma of the lung. One of the major factors considered when assessing the prognosis of breast cancer patients is wheth...