Bertrand Jordan
Bertrand Jordan
Since 2017, the CAR-T ex vivo approach has been very successful for the treatment of B cell malignancies in spite of its complexity and cost. A novel method involves transforming T lymphocytes into CAR-T cells in situ (therefore, in vivo) a...
Marc-André Selosse
Marc-André Selosse
Hélène Gilgenkrantz
Hélène Gilgenkrantz
Hélène Gilgenkrantz
Hélène Gilgenkrantz
[Assessing the risk-benefit balance of medicines: Some lessons from Covid-19] [0.03%]
[评估药品的风险效益平衡：来自新冠的一些启示]
Jean-Luc Cracowski,Mathieu Molimard,Vincent Richard et al.
Jean-Luc Cracowski et al.
The efficacy of medications is evaluated by clinical trials. However, such trials are not designed to assess adverse effects, particularly when those are rare. A robust pharmacovigilance system is therefore required to assess risks, supplem...
[Researchers, students, and faculty researchers: how AI has transformed their daily lives] [0.03%]
[研究人员、学生和教师：人工智能如何改变他们的生活]
Laurent Aussel
Laurent Aussel
Since the introduction of ChatGPT in late 2022, academia has undergone a radical transformation in the use of artificial intelligence. While students widely adopted the tool, professors remain concerned about its impact. Initially skeptical...
[Post-COVID neurological sequelae, proposed mechanisms and therapeutic approaches] [0.03%]
[新冠肺炎后的神经系统后遗症及其发病机制和治疗策略]
Anny Slama Schwok
Anny Slama Schwok
Approximately 5 % of patients suffer from the sequelae of the COVID-19 pandemics, representing a considerable number of individuals, often young or middle-aged working adults (18-50 years). Among them, women are disproportionately affected....
Eléanor Luce,Jean-Charles Duclos-Vallée
Eléanor Luce
Recent advances in stem cell biology and tissue engineering have profoundly renewed the field of liver organoids. More mature and complex, they now incorporate functional canalicular networks, metabolic gradients, and co-cultures including ...
Étienne Ruppé,Philippe Glaser
Étienne Ruppé
Antibiotic resistance is a major public health issue, responsible for around one million deaths worldwide each year. It arises in bacteria as a result of mutations or horizontal gene transfer of resistance genes. The environment plays a cru...
Katerina Jerabkova-Roda,Vincent Hyenne,Jacky G Goetz
Katerina Jerabkova-Roda
Long considered mere degradative compartments, lysosomes are now recognized as key regulators of metabolism, signaling, and tumor invasion. Here, we discuss how their intracellular localization controls their function, signaling, and secret...