Procaine hydrochloride improves DSS-induced colitis via inhibition of IL-6/STAT3 and FOXP3 methylation [0.03%]
procaine通过抑制IL-6/STAT3和FOXP3甲基化改善DSS诱导的结肠炎
An Xiong,Yi Tian,Xin Liang et al.
An Xiong et al.
Backgrounds: Disruption of immune barrier function is considered a hallmark feature of inflammatory bowel disease. In the present study, the potential effects of the methyltransferase inhibitor procaine hydrochloride on i...
VEGFC as a prognostic cytokine biomarker linking lymph node metastasis to immune suppression in breast cancer [0.03%]
乳腺癌中作为预后细胞因子生物标志物的VEGFC与淋巴结转移相关免疫抑制之间的关联
Hsing-Ju Wu,Yu-Chieh Tsai,Hung-Yu Lin
Hsing-Ju Wu
Backgrounds: Lymph node metastasis is a critical determinant of breast cancer prognosis, yet the specific microenvironmental cytokines driving this process remain elusive. This study aims to identify key prognostic cytoki...
Targeting the cytokine-epigenetic axis: a new paradigm and prospects for disease treatment [0.03%]
靶向细胞因子表观遗传轴：一种新的范式和疾病治疗前景
Yuyue Luo,Yikan Zheng,Jie Qin et al.
Yuyue Luo et al.
Cytokines, as key signaling molecules, are involved in the regulation of physiological and pathological processes such as inflammation, immunity, and cell growth. Epigenetic mechanisms, including DNA methylation, histone modifications, chro...
Cytokine signalling in vaginal epithelial cells: mechanistic insights into epithelial immunity and inflammatory milieu in vulvovaginal candidiasis [0.03%]
阴道上皮细胞细胞因子信号转导：上皮免疫和念珠菌病炎症微环境的机制见解
Kavee Shree Sukumaran,Nelli Giribabu,Naguib Salleh
Kavee Shree Sukumaran
Vulvovaginal candidiasis (VVC) is one of the most prevalent mucosal infections worldwide, experienced by women throughout their reproductive years. Candida albicans is involved in 85-95% of all VVC cases and given the stronger correlation b...
Xenosialylation as immunological chimerism: a host-centered unifying model for viral and post-vaccination immune complications [0.03%]
异种糖基化作为免疫嵌合体：一种以宿主为中心的病毒和疫苗接种后免疫并发症统一模型
Fiorella Carnevali,Maria Chiara Muollo,Lucia Biagini et al.
Fiorella Carnevali et al.
Severe immune-mediated complications following viral infections and vaccinations, including COVID-19 and anti-SARS-CoV-2 immunization, display remarkable clinical overlap despite occurring in distinct biological contexts. In a previous hypo...
Emerging viral infections: role of flavivirus NS1-mediated rewiring of PRR signaling [0.03%]
黄病毒NS1介导的PRR信号重编程与新兴病毒感染
Matteo Ferraresi,Giulia Pezzi,Silvia Beltrami et al.
Matteo Ferraresi et al.
Flaviviruses, including Dengue, West Nile, Zika, and Japanese encephalitis viruses, are arthropod-borne RNA viruses that pose an increasing global health threat. This review summarizes the role of nonstructural protein 1 (NS1), a multifunct...
Co-expression of CCR7 and H3K9me3 identifies aggressive B-cell lymphoma with bone marrow infiltration and poor prognosis [0.03%]
CCR7与H3K9me3共表达识别具有骨髓浸润及预后不良的侵袭性B细胞淋巴瘤
Jiawen Chen,Zelin Liu,Keke Huang et al.
Jiawen Chen et al.
Objectives: B-cell lymphoma exhibits significant clinical heterogeneity, necessitating improved biomarkers for risk stratification. C-C chemokine receptor 7 (CCR7) and trimethylation of histone H3 lysine 9 (H3K9me3) are i...
Re-evaluating cytokine storm syndromes: dysregulated host defense or contextual immune adaptation? [0.03%]
重新评估细胞因子风暴综合征：失调的宿主防御还是情境性免疫适应？
Kamaljeet;Abhishek Vijukumar,Hardik Kumar,Shilpa Debnath et al.
Kamaljeet;Abhishek Vijukumar et al.
Cytokine storm syndromes have become a much-invoked concept to describe severe immunopathology in infectious, inflammatory, and iatrogenic diseases, but the concept is poorly defined and often mechanistically imprecise. High levels of syste...
Propolis as a potential modulator of aryl hydrocarbon receptor signaling in inflammation [0.03%]
propolis通过调节芳香烃受体信号通路在炎症中的潜在作用
Natália Alvarenga Borges,Larissa Manhães,Ludmilla Dias de Santana E Santana et al.
Natália Alvarenga Borges et al.
The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that exhibits antagonistic pleiotropy, mediating both protective and detrimental cellular effects depending on the ligand and context. AhR can be activated by a ...
Association between interleukin-6 promoter polymorphisms and osteoporosis in javanese postmenopausal women [0.03%]
白细胞介素6启动子多态性与爪哇后裔绝经期妇女骨质疏松症的相关性研究
Sri Lestari Utami,Mohammad Hidayat,Diana Lyrawati et al.
Sri Lestari Utami et al.
The expression of the interleukin-6 (IL-6) gene promoter and its variations in postmenopausal women of Javanese ethnicity remains unexplored. This study aimed to examine IL-6 promoter polymorphisms at positions -174G/C, -572G/C, -597A/G, an...