Self-propelled biohybrids co-deliver oxaliplatin and glucose oxidase for multimodal treatment of colon cancer [0.03%]
一种自我驱动的生物混合体用于协同递送奥沙利铂和葡萄糖氧化酶治疗结肠癌
Hongjun Deng,Shilin Xu,Kang Xiong et al.
Hongjun Deng et al.
As a frontline chemotherapeutic agent for colorectal cancer, oxaliplatin (OXA) exhibits significantly reduced therapeutic efficacy and may induce severe adverse effects, primarily due to limited targeting capacity and impaired drug penetrat...
Anti-prion drugs reduce endoplasmic reticulum stress and protect human dopaminergic neurons from death [0.03%]
抗朊药物可降低内质网应激并保护人类多巴胺能神经元免于死亡
Lucile Gentile,Adeel Nasir,Loane Simon et al.
Lucile Gentile et al.
Parkinson's disease (PD) is characterized by the pathologic aggregation of α-synuclein, which induces endoplasmic reticulum (ER) stress and activates the unfolded protein response (UPR), ultimately leading to the death of dopaminergic neur...
Binding domains of α-synuclein receptors with monomeric/oligomeric α-synuclein: Implications for Parkinson's disease [0.03%]
单体/寡聚α-突触核蛋白与α-突触核蛋白受体结合域：帕金森病的潜在治疗靶标
Rosalie Elvira,Jia Sheng Guan,Yuguang Mu et al.
Rosalie Elvira et al.
Parkinson's disease (PD) and related synucleinopathies are characterized by the pathological aggregation and spread of alpha-synuclein (α-syn), a protein central to neurodegeneration. Currently three neuronal receptors -Family with sequenc...
Corrigendum to "In vitro screening of synbiotics based on a four-strain probiotic blend and their therapeutic potential for ulcerative colitis" [Biomed. Pharmacother., vol. 191 (2025) page 118521] [0.03%]
关于“基于四种益生菌混合物的合生元体外筛选及其治疗溃疡性结肠炎的潜力”的勘误(《生物医学和药物疗法》第191卷(2025年)页码118521)
Jiahao Liao,Ying Guo,Zhuoya Guo et al.
Jiahao Liao et al.
Mitochondrial stress bridge: Could muscle-derived extracellular vesicles be the missing link between sarcopenia, insulin resistance, and chemotherapy-induced cardiotoxicity? [0.03%]
线粒体压力桥梁：肌细胞源性外泌体是否是肌肉减少症、胰岛素抵抗和化疗诱导的心脏毒性之间的缺失环节？
Okechukwu Paul-Chima Ugwu,Fabian C Ogenyi,Chinyere Nneoma Ugwu et al.
Okechukwu Paul-Chima Ugwu et al.
Sarcopenia is currently considered a systemic condition that goes beyond muscle atrophy to include multifunctional metabolic and cardiovascular dysfunction. The mediators between skeletal muscle loss and entire body insulin resistance and i...
Revisiting soluble guanylate cyclase pharmacology: Additive potential of stimulators and activators [0.03%]
可溶性鸟苷酸环化酶药理的再研究：刺激剂和激活剂的附加潜力
Alexandra Petraina,Mahmoud H Elbatreek,Christopher T Neullens et al.
Alexandra Petraina et al.
Nitric oxide (NO) is a key gasotransmitter that binds to soluble guanylate cyclase (sGC), thereby stimulating cGMP production. Under disease conditions, reactive oxygen species disrupt this signaling by either: (1) scavenging NO, or (2) pro...
Exosomal microRNA in diabetic myocardial disorder: Mechanisms, diagnosis, and treatment [0.03%]
糖尿病心肌病变的外泌体微小核糖核酸：机制、诊断和治疗
Yunfeng Yu,Xinyu Yang,Yuman Yin et al.
Yunfeng Yu et al.
Exosomes are intracellular vesicles formed through the endocytic pathway, progressing from early endosome formation to late endosome maturation, multivesicular body generation, and fusion with the plasma membrane. MicroRNAs (miRs), key func...
Anti-cathepsin D antibody-drug conjugates for the targeted delivery of monomethyl auristatin F and E elicit potent anticancer activity in breast cancer [0.03%]
抗Cathepsin D抗体-药物偶联物可有效携带单甲基auristatine F和E，用于乳腺癌的靶向治疗
Diane Nishimwe,Gaëlle Guillon,Aude Mallavialle et al.
Diane Nishimwe et al.
Breast cancer (BC) is the leading cause of cancer deaths in women. Patients with estrogen receptor-positive (ER+) and human epidermal growth factor receptor 2-negative or low (HER2-; HER2low) BC exhibit a late recurrence pattern and resista...
Fangchinoline suppresses melanoma metastasis by inducing senescence of circulating tumor cells [0.03%]
方樟碱通过诱导循环肿瘤细胞衰老抑制黑色素瘤转移
Junhao Chen,Jianyang Hu,Jiapeng He et al.
Junhao Chen et al.
Melanoma metastasis is largely driven by blood-borne dissemination of circulating tumor cells (CTCs), yet effective strategies to target them remain limited. Using patient-derived CTC experimental systems, we identified Fangchinoline, a bis...
Corrigendum to "Apixaban kinetics could be influenced by sex, cytochrome P450 enzymes and SLC6A2 transporter" [Biomed. Pharmacother. 193 (December) (2025) 118732] [0.03%]
关于“阿哌沙班的药动学可能受性别、细胞色素P450酶和SLC6A2转运蛋白的影响”的勘误[生物医学和药物治疗，第193卷（2025年12月），118732]
Eva González-Iglesias,Dolores Ochoa,Houwaida Abbes et al.
Eva González-Iglesias et al.