Cytosolic DNA sensing pathway in senescence and aging: Underlying mechanisms and targeted interventions [0.03%]
细胞DNA感受通路在衰老中的作用机制及干预策略
Elaheh Alipour-Khezri,Amin Moqadami,Sepideh Zununi Vahed et al.
Elaheh Alipour-Khezri et al.
The global increase in the older population presents major healthcare challenges due to increased prevalence of age-related diseases. Cellular senescence is a defining feature of aging, and the cyclic GMP-AMP synthase (cGAS) and stimulator ...
Cyclic nucleotide phosphodiesterase 1 and cognitive impairment: Mechanistic insights and therapeutic implications [0.03%]
环核苷酸磷酸二酯酶1与认知障碍：机制见解及治疗意义
Hailiang Li,Olivia Brzostek,Jason Sherman et al.
Hailiang Li et al.
Cognitive impairment is a defining feature of neurodegenerative diseases such as Alzheimer's disease (AD) and vascular dementia (VaD). However, the pathogenesis of cognitive impairment remains unclear, mainly because it involves complex pat...
KN21, a direct AMPK activator, alleviates hepatic steatosis and fibrosis by modulating long-chain TAG and pyrimidine metabolism in a MASH mouse model [0.03%]
KN21直接激活AMPK通过调节长链三酰甘油和嘧啶代谢缓解MASH小鼠模型的肝脂肪变性和纤维化
Jueun Lee,Seojeong Kim,Yeajin Ju et al.
Jueun Lee et al.
Metabolic dysfunction-associated steatohepatitis (MASH) is a severe form of metabolic dysfunction-associated steatotic liver disease (MASLD) that is characterized by hepatic steatosis, inflammation, and fibrosis and can progress to cirrhosi...
Apoptosis-promoting autophagy mediates anti-migratory effects of unsymmetrical bisacridines in pancreatic cancer cells [0.03%]
不对称双吖啶通过促进细胞凋亡介导胰腺癌细胞的抗迁移效应
Agnieszka Kurdyn,Bożena Pezała,Ewa Paluszkiewicz et al.
Agnieszka Kurdyn et al.
Pancreatic cancer (PC) remains one of the most lethal malignancies, underscoring the urgent need for new therapeutic strategies. Our previous studies demonstrated that unsymmetrical bisacridines (UAs) exhibit strong anticancer activity agai...
Corrigendum to "Mechanical stress protects against chondrocyte pyroptosis through TGF-β1-mediated activation of Smad2/3 and inhibition of the NF-κB signaling pathway in an osteoarthritis model" [Biomed. Pharmacother., 2023 Mar:159:114216. doi: 10.1016/j.biopha.2023.114216. Epub 2023 Jan 11] [0.03%]
“机械应力通过TGF-β1介导的Smad2/3激活和NF-κB信号通路抑制保护软骨细胞焦亡： biomed. pharmacother., 2023年3月:159卷:114216的勘误表”
Yang Wang,Zhuangzhuang Jin,Shuangshuo Jia et al.
Yang Wang et al.
Corrigendum to "Undesirable ER stress induced by bavachin contributed to follicular atresia in zebrafish ovary" [Biomed. Pharmacother. 166 (2023) 115322] [0.03%]
关于“巴瓦チン诱导的不良内质网应激导致斑马鱼卵巢卵泡闭锁”的勘误[Biomed. Pharmacother. 166 (2023) 115322]
Cong-Shu Huang,Hui-Fang Deng,Lei Zhou et al.
Cong-Shu Huang et al.
Antagonizing epigenetically controlled PAF/PAF-R pathway improves liver function during experimental cirrhosis [0.03%]
表观遗传调控的PAF/PAF-R通路拮抗剂可改善实验性肝硬化肝功能
Enrique Ángel-Gomis,Esther Caparrós,Isabel Gómez-Hurtado et al.
Enrique Ángel-Gomis et al.
Background and aims: Platelet-activating factor (PAF) phospholipid is mainly produced by macrophages and involved in pro-inflammatory responses. We evaluated the regulation of PAF-R gene expression during experimental cir...
Next-generation CAR T cells targeting integrin αvβ6 and PD-L1 to enhance immunotherapy for cholangiocarcinoma [0.03%]
下一代靶向整合素αvβ6和PD-L1的CAR-T细胞以增强肝内胆管癌免疫治疗的效果
Chalermchai Somboonpatarakun,Nattaporn Phanthaphol,Kwanpirom Suwanchiwasiri et al.
Chalermchai Somboonpatarakun et al.
Cholangiocarcinoma (CCA) is an aggressive epithelial malignancy characterized by poor prognosis, limited treatment options, and high recurrence rates even after surgery. Chimeric antigen receptor (CAR) T cell therapy has achieved notable su...
The CXCL13-CXCR5 axis and follicular cytotoxic T cells: Linking T-B crosstalk in autoimmune diseases [0.03%]
CXCL13-CXCR5轴和滤泡性细胞毒性T细胞：自身免疫性疾病中T-B相互作用的联系
Shun-Yu Yao,Yong Peng,Xiuli Zhang et al.
Shun-Yu Yao et al.
Follicular cytotoxic T (Tfc) cells, a distinct subset of CXCR5⁺CD8⁺ T lymphocytes, have recently gained attention for their dual roles in cytotoxicity and immune regulation within lymphoid follicles. Unlike conventional cytotoxic T cells,...
Development of recombinant Mesozumab-CPTin that dual-targets mesothelin and CP2c for anticancer therapy [0.03%]
一种同时靶向间皮素和CP2c的重组Mesozumab-CPTin的开发用于癌症治疗
Boram Kim,Kyu Tae Byun,Junmin Cho et al.
Boram Kim et al.
Current pharmacotherapeutics using antibody-drug conjugates (ADCs) for cancer therapy present limitations, such as off-target effects and safety concerns. To address them, we have developed CPTin, a cell-penetrating, cancer cell-specific cy...