Endothelial dysfunction: Pathophysiology and therapeutic targets for sepsis-induced multiple organ dysfunction syndrome [0.03%]
内皮功能障碍：脓毒症诱导的多器官功能综合征的病理生理和治疗靶点
Fei Tang,Xiao-Lan Zhao,Li-Yue Xu et al.
Fei Tang et al.
Sepsis and septic shock are critical medical conditions characterized by a systemic inflammatory response to infection, significantly contributing to global mortality rates. The progression to multiple organ dysfunction syndrome (MODS) repr...
Exploring the high-quality ingredients and mechanisms of Da Chuanxiong Formula in the treatment of neuropathic pain based on network pharmacology, molecular docking, and molecular dynamics simulation [0.03%]
基于网络药理学、分子对接和分子动力学模拟探讨大川芎制剂治疗神经病理性疼痛优质药材及机制
Jinshi Li,Dongxu Wang,Xiaotong Hao et al.
Jinshi Li et al.
Da Chuanxiong Formula (DCXF) is a traditional herbal prescription used for pain management. It consists of Chuanxiong Rhizoma (CR) and Gastrodiae Rhizoma (GR). Despite its long history of use, the underlying therapeutic mechanism of DCXF re...
How neutrophils shape the immune response of triple-negative breast cancer: Novel therapeutic strategies targeting neutrophil extracellular traps [0.03%]
中性粒细胞如何塑造三阴性乳腺癌的免疫反应：针对中性粒细胞胞外诱捕网的新型治疗策略
Bing Liang,Ye Yuan,Qianheng Jiang et al.
Bing Liang et al.
Triple-negative breast cancer (TNBC) is labeled as an aggressive type of breast cancer and still has limited therapeutic targets despite the advanced development of cancer therapy. Neutrophils, representing the conventional inflammatory res...
The communication mechanism of the gut-brain axis and its effect on central nervous system diseases: A systematic review [0.03%]
肠-脑轴的交流机制及其对中枢神经系统疾病的影响：系统性综述
Shengwen Lu,Qiqi Zhao,Yu Guan et al.
Shengwen Lu et al.
Gut microbiota is involved in intricate and active metabolic processes the host's brain function, especially its role in immune responses, secondary metabolism, and symbiotic connections with the host. Gut microbiota can promote the product...
Mycobacterium bovis BCG reverses deleterious effects of H. pylori components towards gastric barrier cells in vitro [0.03%]
BCG逆转幽门螺旋杆菌成分对胃粘膜屏障细胞的不良影响
Weronika Gonciarz,Patrycja Płoszaj,Magdalena Chmiela
Weronika Gonciarz
Mycobacterium bovis (M. bovis) Bacillus Calmette-Guerin (BCG) strain used in immunotherapy of bladder cancer (onco-BCG) due to its acid tolerance can be a candidate for prevention or reversion of deleterious effects towards gastric cell bar...
L-arginine attenuates dichlorvos-induced testicular toxicity in male Wistar rats by suppressing oxidative stress-dependent activation of caspase 3-mediated apoptosis [0.03%]
L-精氨酸通过抑制氧化应激依赖的半胱天冬酶3介导的凋亡来缓解敌敌畏诱导的大鼠睾丸毒性
W A Saka,A E Adeogun,V I Adisa et al.
W A Saka et al.
Background: The continuous use of pesticides, such as dichlorvos, is a common agricultural and domestic practice. However, it is associated with shortfalls like testicular toxicity through the induction of oxidative stres...
PBMC therapy reduces cell death and tissue fibrosis after acute kidney injury by modulating the pattern of monocyte/macrophage survival in tissue [0.03%]
外周血单个核细胞治疗通过调节单核/巨噬细胞在组织中的存活模式降低急性肾损伤后的细胞死亡和组织纤维化
Selene Torrico,Georgina Hotter,Ángeles Muñoz et al.
Selene Torrico et al.
In this study, we investigated if the therapeutic potential of peripheral blood mononuclear cell (PBMC) therapy in a murine model of ischemic AKI is related with the survival pattern of monocyte/macrophages in tissue. CD-1 mice were subject...
The natural compound sinometumine E derived from Corydalis decumbens promotes angiogenesis by regulating HIF-1/ VEGF pathway in vivo and in vitro [0.03%]
防己黄药中活性成分新代延胡素E通过调节缺氧诱导因子-1/血管内皮生长因子信号通路促进体内外新生血管形成
Yuqi Wang,Shuhui Wang,Yanhang Wang et al.
Yuqi Wang et al.
The rhizome of Corydalis decumbens is a traditional Chinese medicine commonly utilized in the clinical treatment of acute ischemic stroke. Numerous phytochemical and biological investigations have demonstrated that protoberberine alkaloids ...
Review of pre-metastatic niches induced by osteosarcoma-derived extracellular vesicles in lung metastasis: A potential opportunity for diagnosis and intervention [0.03%]
骨肉瘤来源的细胞外囊泡诱导肺转移前生态位的研究：诊断和干预的机会展望
Xia Zhongyu,Xu Wei,Zhang Hongmei et al.
Xia Zhongyu et al.
Osteosarcoma (OS) has a high propensity for lung metastasis, which is the leading cause of OS-related death and treatment failure. Intercellular communication between OS cells and distant lung host cells is required for the successful lung ...
Advances in the development of lipid nanoparticles for ophthalmic therapeutics [0.03%]
眼科治疗中脂质纳米颗粒开发的进步
Shen Chen,Zhihong Deng,Dan Ji
Shen Chen
Previously, researchers have employed Lipid nanoparticles (LNPs) to directly encapsulate medicines. In the realm of gene therapy, researchers have begun to employ lipid nanoparticles to encapsulate nucleic acids such as messenger RNA, small...