Innovative CAR-T approaches targeting Claudin 18.2 to counteract drug resistance in gastric cancer [0.03%]
创新的CAR-T方法靶向Claudin 18.2以对抗胃癌药物耐药性
Giovanni Calice,Carlo Calabrese,Tiziana Notarangelo
Giovanni Calice
Claudins, integral components of tight junctions, have recently emerged as key modulators of drug resistance in gastric cancer. Claudin18.2 is aberrantly expressed in a subset of gastric tumors, where it disrupts epithelial integrity and pr...
β-glucan-loaded nano-niosomes ameliorate spatial and associative memory impairment in a D-galactose-induced aging rat model via modulation of microglial pyroptosis and autophagy [0.03%]
β-葡聚糖载药nano-niosome通过调节小胶质细胞pyroptosis和自噬改善d-半乳糖诱导的大鼠衰老模型的空间记忆和联想记忆损伤
Fatemeh Rahmati-Dehkordi,Elham Zahedi,Soheila Adeli et al.
Fatemeh Rahmati-Dehkordi et al.
Introduction: Considering the anti-inflammatory effects of β-glucan, a natural polysaccharide, this study investigated whether β-glucan nano-formulated in niosomes (vesicles made of non-ionic surfactants used for drug d...
Laser-activated NGQDs boost the therapeutic response of 5-FU in breast cancer cells [0.03%]
激光激活的NGQDs可增强5-FU在乳腺癌细胞中的治疗效果
Seyedeh Zohreh Azarshin,Masoud Mozaffari,Jaber Zafari et al.
Seyedeh Zohreh Azarshin et al.
The development of efficient therapeutic approaches for cancer has attracted much attention. Photodynamic therapy combines photosensitizer materials with a laser to enhance ROS production at the tumor site, leading to cancer cell apoptosis....
Exosome therapeutics: A paradigm shift in skin repair through multidimensional immunomodulation and biomaterial-driven delivery [0.03%]
外泌体治疗：通过多维度免疫调节和生物材料驱动的递送实现皮肤修复的新范式
Tinghan Deng,Yiyi Zhang,Yabo Yao et al.
Tinghan Deng et al.
Exosomes, nanoscale extracellular vesicles (30-150 nm) carrying bioactive molecules such as proteins, miRNAs, and lipids, are pivotal mediators of skin repair, modulating immune responses, angiogenesis, oxidative stress, and fibroblast func...
Endoplasmic reticulum, mitochondria, and their crosstalk in retinal ganglion cell degeneration [0.03%]
内质网、线粒体及其对话在视网膜神经节细胞退变中的作用
Baohua Li,Yipeng Shi,Mengyu Liu et al.
Baohua Li et al.
Retinal ganglion cells (RGCs) serve as the terminal output neurons in the retina and are responsible for transmitting visual information from photoreceptors to higher-level centers in the brain. Because of their highly polarized structure, ...
Cyclooxygenase-2 inhibition improves hypercholesterolemia-induced cardiac dysfunction [0.03%]
环氧化酶-2抑制改善高胆固醇血症所致的心功能不全
Bernadett Kiss,Regina N Nagy,Gábor B Brenner et al.
Bernadett Kiss et al.
Hidden cardiotoxicity is defined as cardiotoxicity of a drug that manifests only in the diseased heart. We have previously shown that the proarrhythmic hidden cardiotoxic properties of a model drug, the selective cyclooxygenase-2 inhibitor ...
Dapagliflozin enhances hemodynamic and metabolic recovery following cardioplegic arrest in the isolated working mouse heart [0.03%]
达格列净可增强心肌停搏的工作型单个体小鼠心脏的血流动力学和代谢恢复效果
Christopher Dostal,Johanna Reiner,Daniel Spona et al.
Christopher Dostal et al.
Objective: This experimental study investigates the potential of sodium-glucose cotransporter 2 inhibitor (SGLT2i) dapagliflozin to enhance cardiac hemodynamic and metabolism function following ischemia/reperfusion (I/R) ...
A new biocompatible amino-Gd-metallofullerenol (Amino-Gd-FulOH) nanoplatform as a potential MRI contrast agent and its effect on macrophages [0.03%]
一种新型生物相容性氨基-Gd-金属富勒烯醇(Amino-Gd-FulOH)纳米平台作为磁共振成像对比剂及其对巨噬细胞的影响研究
Marta Halasa,Beata Brzozowska,Malgorzata Kloc et al.
Marta Halasa et al.
Endohedral gadolinium-containing metallofullerenols are promising multifunctional nanomaterials with low cytotoxicity and strong imaging capabilities. Structurally organized at atomic, molecular, and supramolecular levels, these nanoparticl...
Ardisiaoside A, a new triterpenoid glycoside from Ardisia gigantifolia, induces cell senescence and targets cancer stem cells in gastric cancer [0.03%]
牵牛花素A，牵牛花素纲叶大属中的三萜苷，可诱导胃癌细胞衰老并靶向胃癌干细胞
Van Khang Pham,Thi Thanh Huong Le,Nguyet Mai Hua et al.
Van Khang Pham et al.
This study aimed to isolate bioactive constituents from Ardisia gigantifolia and assess their effects on gastric cancer stem cells (CSCs) properties. Cytotoxicity and proliferation were quantified using the MTT assay; cell-cycle distributio...
Nanobody CAR-T cells in cancer: From molecular design to clinical translation [0.03%]
纳米抗体CAR-T细胞在癌症治疗中的应用：从分子设计到临床转化
Alaa Rifaah Eisa,Fatemeh Tavassoli Razavi,Akram Hoseinzadeh et al.
Alaa Rifaah Eisa et al.
Chimeric antigen receptor (CAR)-T cell therapy has revolutionized the management of hematologic malignancies. This review provides an overview of nanobody-based CAR-T therapy, highlighting how structural advancements in single-domain antibo...