Rapid transcellular hepatic copper depletion by ARBM-101 rescues severe liver damage in Wilson disease rodents [0.03%]
ARBM-101通过快速的肝细胞内铜耗竭拯救威尔森病啮齿动物严重的肝脏损伤
Jonas Engler,Eun-Jung Kim,Dasol Kim et al.
Jonas Engler et al.
In Wilson disease (WD), excess copper provokes hepatocyte death due to impaired copper excretion, ultimately causing either acute or chronic liver damage. Current therapeutic compounds fail to reduce hepatic copper near to physiological lev...
Israel Martínez-Espinosa,José A Serrato,Jesús Germán-Valenzuela et al.
Israel Martínez-Espinosa et al.
Metastasis to distant organs remains the primary cause of cancer-related death worldwide. Although progress has been made in understanding the mechanisms behind metastasis, the processes that drive tumor cells to invade and colonize distant...
A comparative study of idarubicin and doxorubicin in a chemically-induced in vivo mouse model for hepatocellular carcinoma [0.03%]
异基因移植肝癌小鼠模型中idarubicin和doxorubicin的比较研究
Ada Lerma-Clavero,Maria Kopsida,Nathalie Arendt et al.
Ada Lerma-Clavero et al.
Hepatocellular carcinoma (HCC) remains a major therapeutic challenge with limited systemic treatment options and suboptimal response rates. Anthracyclines such as doxorubicin (DOX) and idarubicin (IDA) are frequently used in clinical settin...
Arkadiusz Grzeczka,Szymon Graczyk,Xutong Gong et al.
Arkadiusz Grzeczka et al.
Sirtuins are NAD⁺-dependent enzymes involved in metabolic regulation, aging, oxidative stress response, and inflammation, all of which are pivotal in the development of myocardial fibrosis. SIRT1, SIRT3, and SIRT6 are shown to exert protec...
Dexmedetomidine in ischemic and hemorrhagic brain injury: Neuroprotection from mechanisms to therapy [0.03%]
从机制到治疗：右美托咪定在缺血性和出血性脑损伤中的神经保护作用
Yixiao Zhu,Andi Chen,Chenglin Gai et al.
Yixiao Zhu et al.
Dexmedetomidine (DEX), a highly selective α2-adrenergic receptor agonist extensively used for sedation in clinical anesthesia, has recently attracted significant attention for its neuroprotective properties. These effects are mediated thro...
Immune checkpoint inhibition in renal cell carcinoma: Mechanisms of resistance and emerging therapeutic strategies [0.03%]
肾细胞癌中的免疫检查点抑制：耐药机制与治疗策略的发展方向
Ali Darzi,Mahla Shokouhfar,Narges Farajee et al.
Ali Darzi et al.
Renal cell carcinoma (RCC) represents a major therapeutic challenge due to its highly immunosuppressive tumor microenvironment. Over the past decade, immune checkpoint inhibitors (ICIs) have revolutionized the management of advanced RCC, sh...
Metabolic modulation as a therapeutic strategy for post-acute vaccination syndrome (PACVS): A review of pathomechanisms and existing therapeutic components [0.03%]
代谢调节作为治疗急性疫苗反应综合征(PACVS)的策略：病理机制和现有治疗方法综述
Matthew Halma,Joseph Varon
Matthew Halma
Post-Acute Vaccination Syndrome (PACVS) is a post-vaccination disorder marked by persistent fatigue, cognitive impairment, and exercise intolerance. Current research identifies interconnected pathophysiological processes, including persisti...
Retraction notice to "Chaiqin chengqi decoction alleviates severe acute pancreatitis associated acute kidney injury by inhibiting endoplasmic reticulum stress and subsequent apoptosis" [Biomed. Pharmacother. 125 (2020) 110024] [0.03%]
撤稿通知：“柴芩清胰汤通过抑制内质网应激及其介导的凋亡治疗急性重症胰腺炎相关性急性肾损伤[Biomed. Pharmacother. 125 (2020) 110024]”
Xuefei Yang,Xiaoxin Zhang,Ziqi Lin et al.
Xuefei Yang et al.
Retraction notice to "INF2 regulates oxidative stress-induced apoptosis in epidermal HaCat cells by modulating the HIF1 signaling pathway" [Biomed. Pharmacother., 111 (2019) 151-161] [0.03%]
有关“INF2通过调节HIF1信号通路调控氧化应激诱导的表皮HaCaT细胞凋亡”[Biomed. Pharmacother., 111 (2019) 151-161] 的撤稿通知
Zhixiong Chen,Chenyu Wang,Nanze Yu et al.
Zhixiong Chen et al.
Retraction notice to "Long noncoding RNA OIP5-AS1 promotes the progression of oral squamous cell carcinoma via regulating miR-338-3p/NRP1 axis" [Biomed. Pharmacother. 118 (2019) 109259] [0.03%]
撤销生物医学与药物疗法中题为“长链非编码RNA OIP5-AS1通过调节miR-338-3p/NRP1轴促进口腔鳞状细胞癌的发展”一文的通知[2019年118卷109259页]
Minghe Li,Jun Ning,Zhihong Li et al.
Minghe Li et al.