Enhancing colorectal cancer treatment with a triple therapy approach involving 5-fluorouracil, thymoquinone, Polygonum minus [0.03%]
一种新型联合疗法可有效治疗结直肠癌：5-氟尿嘧啶、芹菜素和Polygonum minus联合治疗
Kshidan Marim Abdullah Salem,Ibrahim Malami,Kim Wei Chan et al.
Kshidan Marim Abdullah Salem et al.
Colorectal cancer (CRC) remains a leading cause of cancer-related mortality globally, with chemoresistance to 5-fluorouracil (5-FU) and dose-limiting toxicities posing major therapeutic challenges. This study investigates the synergistic po...
Role of anthocyanins in protecting chondrocytes from high glucose damage through SIRT-1 and autophagy in diabetic osteoarthritis [0.03%]
花青素通过SIRT-1和自噬保护高糖所致糖尿病骨关节炎软骨细胞损伤的作用研究
Benjawan Wudtiwai,Pattaralawan Sittiju,Aitthiphon Chongchai et al.
Benjawan Wudtiwai et al.
Diabetes mellitus is linked to osteoarthritis through high glucose (HG)-induced inflammation and chondrocyte apoptosis, causing cartilage degradation. Preventing these processes may mitigate diabetic osteoarthritis. This study evaluated the...
In vitro assessment of pirfenidone anti-fibrotic properties in a humanized 3D bioprinted kidney tubulointerstitium model [0.03%]
皮尔菲尼东抗纤维化特性的体外评估：人源化3D生物打印肾小管间质模型的应用
Gabriele Addario,Alessandro Bortolin,Lorenzo Moroni et al.
Gabriele Addario et al.
Kidney fibrosis is a hallmark of chronic kidney disease (CKD), characterized by excessive extracellular matrix (ECM) deposition that progressively impairs kidney function. Fibrosis affects multiple segments of the nephron, particularly the ...
Protective effect of a novel metal-phenolic network composite against ultraviolet-induced skin damage by modulating MAPK/AP-1/NF-κB signaling pathways and attenuating oxidative stress in human keratinocytes [0.03%]
一种新型金属酚网络复合物通过调节MAPK/AP-1/NF-κB信号通路和减轻氧化应激来对抗紫外线引起的皮肤损伤的保护作用
Mi Hee Shin,Youngji Kwon,Seunghee Lee et al.
Mi Hee Shin et al.
Ultraviolet irradiation is a major inducer of oxidative stress, inflammation, and extracellular matrix degradation in skin, which contribute to photoaging. Melamax®, a novel metal-phenolic network (MPN)-based composite hair dye, was primar...
Metabolic profiles of the human blood-brain barrier cells treated by TNF-alpha and oxysterols [0.03%]
TNF-α和氧化固醇处理的人源血脑屏障细胞代谢谱型分析
Cindy Nguyen,Kenneth C P Cheung,Xiaoli Chen et al.
Cindy Nguyen et al.
The blood-brain barrier (BBB) is essential for central nervous system homeostasis, and its dysfunction is implicated in neuroinflammatory disorders such as Alzheimer's disease and multiple sclerosis. Oxysterols, cholesterol-derived metaboli...
Temporal and demographic patterns of peripheral nerve proteomes in preclinical neuropathic pain [0.03%]
临床前神经病理性疼痛的周围神经蛋白组的时空和人口统计学特征分析研究
Sabrina Grundtner,Feng Xian,Daniel Malzl et al.
Sabrina Grundtner et al.
Peripheral nerves drive movement and sensation but are highly vulnerable to injury, making them critical sites in the development of neuropathic pain. Nerve trauma initiates profound plasticity, yet the molecular programs driving both early...
Balancing cell cycle arrest and immune activation: A synergistic window for idasanutlin and anti-PD-1 therapy in a syngeneic mouse model [0.03%]
细胞周期阻滞和免疫激活的平衡：idalibulin与抗PD-1疗法在同基因小鼠模型中的协同窗口
Aneta Nieznanska,Malgorzata Statkiewicz,Zuzanna Sandowska-Markiewicz et al.
Aneta Nieznanska et al.
Recent studies have explored combining MDM2 antagonists with immunotherapy. Here, we assessed the effect of anti-PD-1 and idasanutlin co-treatment in a syngeneic CT26/BALB/c mouse model. Prior to in vivo testing, idasanutlin's activity was ...
Synergistic effects of fucoidan from Undaria pinnatifida and grouper peptides on glucocorticoid-induced muscle atrophy via protein turnover modulation [0.03%]
海带硫酸寡糖与石斑鱼寡肽通过调节蛋白质周转缓解糖皮质激素肌萎缩的协同作用机制研究
Huey-Jine Chai,Tsung-Kai Yi,Jerrell Felim et al.
Huey-Jine Chai et al.
Muscle atrophy, whether associated with aging, chronic disease, or glucocorticoid treatment, remains a significant clinical challenge with few effective therapeutic options. This study investigated the protective effects of fucoidan from Un...
The role of gut dysbiosis and mitochondrial dysfunction in type 2 diabetes: Insights on pathogenesis, intervention and future perspective [0.03%]
肠道菌群失调和线粒体功能障碍在2型糖尿病中的作用：发病机制、干预及未来展望的见解
Xuefei Yu,Mingxiao Li,Houkai Li
Xuefei Yu
Type 2 diabetes (T2D) is a typical metabolic disease which is attributed to genetic and environmental factors. Emerging evidence has highlighted that either gut dysbiosis or mitochondrial dysfunction plays critical roles in the development ...
Integrated systems vaccinology reveals distinct metabolic responses to SARS-CoV-2 infection and DNA-based vaccines in ferrets [0.03%]
整合系统疫苗学揭示了雪貂SARS-CoV-2感染和基于DNA的疫苗接种后的代谢反应不同
Gustaf Ahlén,Anoop Ambikan,Flora Mikaeloff et al.
Gustaf Ahlén et al.
Understanding how infection and vaccination reshape systemic metabolism is key to defining protective immunity against SARS-CoV-2. Using a ferret model, we performed untargeted serum metabolomics in two experimental settings: SARS-CoV-2 inf...