Deciphering the immunomodulatory mechanisms of Bojungikki-tang via systematic transcriptomic and immune cell interaction network analysis [0.03%]
基于转录组和免疫细胞互作网络的补君素汤调节免疫机制研究
Sang-Yun Kim,Jin-Mu Yi,Jaemoo Chun et al.
Sang-Yun Kim et al.
Bojungikki-tang (BJIKT), a traditional herbal formula with immunomodulatory properties, has synergistic effects with immune checkpoint inhibitors. However, the detailed molecular mechanisms underlying its effects on various immune cell type...
Downregulation of transforming growth factor-β2 enhances the chemosensitivity to gemcitabine with diminished metastasis in pancreatic cancers [0.03%]
转化生长因子-β2下调可减少转移并增强胰腺癌对吉西他滨的化疗敏感性
Dohee Ahn,Hong Kyu Lee,Sang Hyeok Bae et al.
Dohee Ahn et al.
Pancreatic cancer is characterized by high rates of metastasis, recurrence, and chemoresistance, contributing to its poor prognosis. Transforming growth factor-β2 (TGF-β2), a member of the TGF-β family, plays a pivotal role in promoting ...
Esculetin inhibits liver cancer by targeting glucose-6-phosphate isomerase mediated glycolysis [0.03%]
Esculetin通过作用于葡萄糖-6-磷酸异构酶抑制肝癌中糖酵解的发展
Zongchao Hong,Jingbo Wang,Baodan Hu et al.
Zongchao Hong et al.
Background: Liver cancer is challenging to detect in its early stages, and the global incidence rate and mortality associated with this disease have reached alarming levels. Currently, treatment options for liver cancer a...
Rosa multiflora fructus and its active compound ellagic acid improve depressive-like behaviors in mice via monoamine oxidase inhibition [0.03%]
多花蔷薇果通过单胺氧化酶抑制改善小鼠抑郁样行为及其活性成分ellagic acid的作用机制研究
Minji Kim,Dong Wook Lim,Min-Sun Kim et al.
Minji Kim et al.
Depression is a significant global health challenge, imposing severe social and economic burdens. Rosa multiflora fructus possesses a range of biological properties; however, its role in reducing stress hormone-induced depression remains un...
Unravelling the cardioprotective effects of calcitriol in Sunitinib-induced toxicity: A comprehensive in silico and in vitro study [0.03%]
钙三醇拆解索坦诱导的心脏毒性(cardioprotective effects)的保护作用：一项全面的计算机模拟和体外研究
Yoshika Sakamoto,Takahiro Niimura,Mitsuhiro Goda et al.
Yoshika Sakamoto et al.
Sunitinib (SUN), a drug used to treat advanced renal cell carcinoma and other cancers, causes cardiotoxicity. This study aimed to identify a potential drug candidate to counteract SUN-induced cardiotoxicity. We analysed real-world data from...
Cancer-associated fibroblasts (CAFs) and plaque-associated fibroblasts (PAFs): Unraveling the cellular crossroads of atherosclerosis and cancer [0.03%]
与癌症相关成纤维细胞（CAFs）和与斑块相关的成纤维细胞（PAFs）：揭示动脉粥样硬化和癌症的细胞交叉点
Gavino Faa,Pina Ziranu,Andrea Pretta et al.
Gavino Faa et al.
Atherosclerosis is a complex process involving various cells and molecules within the atherosclerotic plaque. Recent evidence suggests that plaque-associated fibroblasts (PAFs), also known as atherosclerosis-associated fibroblasts (AAFs), m...
Stem cell-mediated bone regeneration of marine-derived fibrinolytic compound (FGFC-1) loaded carboxymethyl chitosan hydrogels [0.03%]
海洋衍生纤溶化合物(FGFC-1)负载的羧甲基壳聚糖水凝胶介导干细胞成骨修复
Lakshmi Jeevithan,Wang Shuyue,Sabu Thomas et al.
Lakshmi Jeevithan et al.
Carboxymethyl chitosan (CMC)-based hydrogels (HG) have gained significant attention for therapeutic applications due to their biomimetic properties and biocompatibility. This study explores, for the first time, the regenerative and osteogen...
Corrigendum to "Bone marrow mesenchymal stem cell exosome-derived lncRNA TUC339 influences the progression of osteoarthritis by regulating synovial macrophage polarization and chondrocyte apoptosis" [Biomed. Pharmacother. 167 (2023) 115488] [0.03%]
骨髓间充质干细胞外泌体来源的长链非编码RNA TUC339通过调节滑膜巨噬细胞极化和软骨细胞凋亡影响骨关节炎进展的勘误[Biomed. Pharmacother. 167 (2023) 115488]
Xun Shen,Jian Qin,Zijian Wei et al.
Xun Shen et al.
MicroRNA-325 ameliorates angiotensin II-induced abdominal aortic aneurysm by inhibiting the endothelial-to-mesenchymal transition through regulation of the MAPK/SNAI1/MMP-2 pathway [0.03%]
miR-325通过调节MAPK/SNAI1/MMP-2信号通路抑制血管内皮细胞间充质转化从而改善AngⅡ诱导的腹主动脉瘤形成
Jen-Chun Wang,Min-Chien Tsai,Shih-Hung Tsai et al.
Jen-Chun Wang et al.
Objective: Angiotensin II (Ang II)-induced chronic inflammation can lead to the formation of abdominal aortic aneurysms (AAAs). Previous studies have revealed associations between endothelial-to-mesenchymal transition (En...
Gianluigi Forloni
Gianluigi Forloni
The identification of active interventions in neurodegenerative disorders is a major challenge in neurology; the use of repurposed drugs may represent a valuable strategy. Tetracyclines, a second generation of antibiotic molecules, offer va...