Clinical stage anti-RGMa monoclonal antibody elezanumab promotes bladder recovery and neuroplasticity after traumatic spinal cord injury [0.03%]
临床阶段抗RGMa单克隆抗体elezanumab可促进脊髓损伤后的膀胱恢复和神经可塑性
Andrea J Mothe,Magdy Hassouna,Christopher Ahuja et al.
Andrea J Mothe et al.
Spinal cord injury (SCI) causes severe and often permanent neurological deficits, including neurogenic lower urinary tract dysfunction. Although restoration of bladder function is a major clinical priority after SCI and would profoundly imp...
Suprachoroidal hydrogel systems for posterior ocular therapy: Design principles, therapeutic applications, and translational challenges [0.03%]
适用于眼后段治疗的超巩膜羟基凝胶系统：设计原理、治疗应用和转化挑战
Zainab Ahmadian,Hirokazu Kaji
Zainab Ahmadian
Suprachoroidal delivery offers a minimally invasive route for targeting the choroid and retina, while reducing complications related to conventional ocular delivery methods. This review focuses on hydrogels engineered for the suprachoroidal...
Chemical synthesis and biological activity of semisynthetic derivatives against Chagas disease and leishmaniasis composed of fragments of natural products and 1,2,3-triazine 1-oxide scaffold [0.03%]
基于天然产物片段和1,2,3-三嗪1-氧化物骨架的抗恰加斯病和利什曼病半合成衍生物的化学合成及生物学活性研究
Diana V Navarrete-Carriola,Adriana Moreno-Rodríguez,Benjamín Nogueda-Torres et al.
Diana V Navarrete-Carriola et al.
Chagas disease and leishmaniasis are neglected diseases caused by Trypanosoma cruzi and Leishmania sp., respectively, leading to morbidity and mortality worldwide and affecting more than 6 million people per year. Despite the availability o...
Adaptive nanocarriers targeting tumor systemic intelligence: A paradigm to overcome systemic barriers in precision drug delivery [0.03%]
针对肿瘤全身智能的适应性纳米载体：精准药物传输克服全身屏障的新范例
Fansu Meng,Majid Sharifi,Laila Abdulmohsen Jaragh-Alhadad et al.
Fansu Meng et al.
Biological barriers remain a primary limitation to effective cancer therapy, restricting drug delivery, distribution, and therapeutic efficacy across tumor sites. These barriers arise from a complex and dynamic interplay between tumor- and ...
Development and characterization of [47Sc]Sc-NOTA-trastuzumab for targeted radiotherapy in primary and metastatic HER2 + breast cancer [0.03%]
47Sc-SC-NOTA-曲妥珠单抗的开发与表征用于原发和转移性HER2阳性乳腺癌的靶向放疗
Patrick N Song,Shelbie J Cingoranelli,Sharmila Sridhar et al.
Patrick N Song et al.
Purpose: This study investigates the potential of [47Sc]Sc-NOTA-trastuzumab as a novel targeted radionuclide agent in HER2 + breast cancer. Targeted radionuclide therapy offers a promising approach for enhanced delivery a...
Panasenoside promotes angiogenesis and mitigates vascular endothelial cell senescence via SIRT1 activation [0.03%]
Panasenoside通过激活SIRT1促进血管生成并缓解血管内皮细胞衰老
Wai-Rong Zhao,Jing Zhang,Guang-Yu Wang et al.
Wai-Rong Zhao et al.
Angiogenesis is a crucial process in ischemia diseases like coronary heart disease, stroke and wound healing. Panasenoside (PSS) is a flavonoid glycoside ioslated from Chinese Materia Medica GINSENG RADIX ET RHIZOMA which has been demonstra...
Expression of concern: "Design and synthesis of benzo[d]thiazol-2-yl-methyl-4-(substituted)-piperazine-1-carbothioamide as novel neuronal nitric oxide inhibitors and evaluation of their neuroprotecting effect in 6-OHDA-induced unilateral lesioned rat model of Parkinson's disease" [Biomed. Pharmacother. 156 (2022) 113838] [0.03%]
表达关切: “设计合成新型神经型一氧化氮抑制剂苯并[d]噻唑-2-基甲基-4-(取代)piperazine-1-碳硫酰胺及其在6-OHDA诱导的帕金森病大鼠模型中的神经保护作用评估” [Biomed. Pharmacother. 156 (2022) 113838]
Corrigendum to "Phage-tail-like bacteriocins as a biomedical platform to counter anti-microbial resistant pathogens" [Biomed. Pharmacother. 155 (2022) 113720] [0.03%]
关于“噬菌体尾丝样细菌素作为对抗抗微生物药物 resistance 病原体的生物医学平台”一文的勘误修正[Biomed. Pharmacother. 155 (2022) 113720]
Rahul Bhattacharjee,Aditya Nandi,Adrija Sinha et al.
Rahul Bhattacharjee et al.
Tumor-associated fibrosis plays a role in cellular immunity across human diseases [0.03%]
肿瘤相关纤维化在人类疾病细胞免疫中的作用
Mengru Tian,Mengyu Lian,Lihao Zheng et al.
Mengru Tian et al.
Tumor-associated fibrosis is a pervasive hallmark of solid malignancies that remodels tissue architecture, biochemical signaling, and mechanical properties, thereby profoundly influencing antitumor cellular immunity across cancers. This rev...
Therapeutic potential of curcumin in Alzheimer's disease: Multi-target mechanisms of action, experimental and clinical evidence, safety aspects [0.03%]
姜黄素治疗阿尔茨海默病的潜力：多靶点作用机制、实验和临床证据以及安全性方面
Gökçe Sueda Aydoğdu,Duygu Ağagündüz,Fiorentina Roviezzo et al.
Gökçe Sueda Aydoğdu et al.
Alzheimer's disease is a neurodegenerative disorder characterized by memory loss and impaired cognitive functions; its prevalence is increasing with the growth of the global elderly population. Unfortunately, early diagnostic and treatment ...