Pharmacological bases of combining nonsteroidal antiinflammatory drugs and paracetamol [0.03%]
非甾体抗炎药与扑热息痛联合使用的药理学基础
Mireia Tena-Garitaonaindia,José Manuel Rubio,Enrique Martínez-Plata et al.
Mireia Tena-Garitaonaindia et al.
Paracetamol and nonsteroidal antiinflammatory drugs (NSAIDs), particularly ibuprofen, are frequently administered together. A systematic review of clinical studies using combined or alternating regimes of NSAIDs was performed up to May 2023...
SARS-CoV-2 S1 protein induces IgG-mediated platelet activation and is prevented by 1.8-cineole [0.03%]
1.8-松油烯可预防SARS-CoV-2 S1蛋白介导的IgG结合诱导血小板活化作用
Julie Petry,Maria Shoykhet,Tobias Weiser et al.
Julie Petry et al.
COVID-19 patients face an increased risk of thromboembolic complications, yet the exact pathophysiological role of platelets in the disease remains unclear. Considering the multifaceted nature of COVID-19 symptoms, including platelet hypera...
Febuxostat alleviate metabolic dysfunction-associated steatohepatitis in rat model via targeting inflammation, cell death, and intestinal barrier dysfunction [0.03%]
febuxostat通过靶向炎症、细胞死亡和肠屏障功能障碍来缓解代谢紊乱相关脂肪肝病的鼠模型研究
Marwa Matboli,Maha Saad,Manar Fouad Ahmed et al.
Marwa Matboli et al.
Metabolic dysfunction-associated steatotic liver disease (MASLD) constitutes a global health threat with its ability to develop into liver cirrhosis and hepatocellular carcinoma (HCC). Emerging data suggests that oxidative stress and regula...
Biophysical and computational insights into lactoferrin-noscapine interaction: Implications for neurodegenerative diseases [0.03%]
乳铁蛋白- noscapine相互作用的生物物理和计算见解：对神经退行性疾病的意义
Anas Shamsi,Moyad Shahwan,Azna Zuberi et al.
Anas Shamsi et al.
Lactoferrin (LTF), a multifunctional glycoprotein, plays a critical role in iron metabolism, host defense mechanisms, and the regulation of inflammatory pathways. It is widely present in various mammalian secretions, including saliva, tears...
Cryo-EM structure of HMGB1-RAGE complex and its inhibitory effect on lung cancer [0.03%]
HMGB1-RAGE复合物的冷冻电镜结构及其对肺癌的影响
Hyeon Jin Kim,Chang Woo Han,Mi Suk Jeong et al.
Hyeon Jin Kim et al.
Mitochondrial dysfunction and mitophagy are closely linked with human diseases such as neurodegenerative diseases, metabolic diseases, and cancer. High-mobility group box 1 (HMGB1) has been shown to mediate a wide range of pathological resp...
Bridging knowledge gaps in phytotherapy for a neglected zoonotic disease: Rift valley fever [0.03%]
bridging knowledge gaps in phytotherapy for a neglected zoonotic disease: rift valley fever 缩小被忽视人畜共患病的植物疗法知识差距：裂谷热
Amin Sharifan
Amin Sharifan
This study sought to review the current state of phytotherapy and natural compound research against Rift Valley fever (RVF), a neglected zoonotic disease exacerbated by climate change and globalisation. A comprehensive literature search was...
From cancer to heart fibrosis - GLIPR1 highlights a subset of myofibroblasts responsive to mesenchymal stem cell therapy after myocardial infarction [0.03%]
从癌症到心肌纤维化(GLIPR1)强调了一组间充质干细胞治疗心梗后的肌成纤维母细胞亚群
Catalina-Iolanda Marinescu-Colan,Evelyn-Gabriela Nastase-Rusu,Carmen-Alexandra Neculachi et al.
Catalina-Iolanda Marinescu-Colan et al.
Despite recent advances in pre-clinical research on cardiac remodeling following myocardial infarction (MI), the precise molecular pathways remain poorly understood and effective therapies for heart failure are still delayed in development....
O6-methylguanine-DNA methyltransferase inhibition leads to cellular senescence and vascular smooth muscle dysfunction [0.03%]
O6-甲基鸟嘌呤-DNA甲基转移酶抑制导致细胞衰老和血管平滑肌功能障碍
Jakub Krivy,Svetozar Misuth,Marina Puchovska et al.
Jakub Krivy et al.
Inhibiting O6-methylguanine-DNA methyltransferase (MGMT) is crucial for overcoming chemoresistance to alkylating agents, though its use is limited by myelosuppression. Beyond bone marrow, other adverse effects were not studied. Given chemot...
A novel noninvasive test based on near-infrared fluorescent cholephilic probes for hepatobiliary secretory function assessment [0.03%]
一种基于近红外荧光胆汁亲和探针的肝胆分泌功能非侵入检测新技术
Beatriz Sanchez de Blas,Alvaro G Temprano,Candela Cives-Losada et al.
Beatriz Sanchez de Blas et al.
Routine serum biomarkers do not always accurately reflect impaired liver function. To overcome this limitation, we synthesized novel bile acid (BA) derivatives (NIRBADs) with near-infrared (NIR) fluorescence that can penetrate the abdominal...
Enhanced tumor suppressive effect of a new HDAC inhibitor in bladder cancer in vitro and in vivo [0.03%]
一种新的HDAC抑制剂的体内外肿瘤抑制作用增强效应研究
Cheng-Huang Shen,Jin-Yi Wu,Shou-Chieh Wang et al.
Cheng-Huang Shen et al.
Bladder cancer has a high recurrence rate, which indicates that the therapeutic effects of advanced bladder cancers are still limited. In this study, we combined vorinostat and cyproheptadine as a new treatment for bladder cancer. When comb...