Wnt activation during epileptogenesis prevents pathological immature dentate granule cell morphological changes in animal models of unilateral and bilateral temporal lobe epilepsy [0.03%]
激活Wnt可在动物颞叶癫痫模型中防止病理性不成熟齿状回颗粒细胞形态变化
Cora Helton,Nicole Rodgers,Kunal Gupta
Cora Helton
Temporal lobe epilepsy (TLE) most commonly presents clinically with unilateral or bilateral hippocampal seizure onsets. Antiseizure medications are often ineffective, and epilepsy surgery outcomes are variable. TLE often occurs after exposu...
Protective effects of ACF210, a dual GLP-1/APJ receptor agonist, against cardiovascular-kidney-metabolic syndrome induced by T2D [0.03%]
一种GLP-1和APJ受体双重激动剂ACF210对2型糖尿病心血管肾脏代谢综合征的保护作用研究
Qingfeng Wu,Huiyi Wei,Huifen Zhou et al.
Qingfeng Wu et al.
Current therapies cannot simultaneously address the interconnected metabolic, cardiac, and renal damage in Cardiovascular-Kidney-Metabolic (CKM) syndrome. This study investigated ACF210, a novel long-acting dual agonist targeting both GLP-1...
Tumor microenvironment-mediated interactions between macrophages and cancer cells define immunoregulatory transcriptional programs [0.03%]
肿瘤微环境介导的巨噬细胞与癌细胞之间的相互作用定义了免疫调节转录程序
Göran Landberg,Mikaela Ståhlberg,Emma Frisk et al.
Göran Landberg et al.
Breast cancer progression is critically shaped by the tumor microenvironment, yet models that preserve patient-specific microenvironmental complexity remain limited. In particular, how the non-cellular microenvironment regulates macrophage-...
Photocontrol of zebrafish behavior with a photoswitchable ligand of nicotinic acetylcholine receptors [0.03%]
用可光切换的烟碱型乙酰胆碱受体配体进行斑马鱼行为的光控制
Claudio Papotto,Nayeli Fernanda Pérez-Pérez,Alexandre M J Gomila et al.
Claudio Papotto et al.
The α7 nicotinic acetylcholine receptor (α7 nAChR) is a key modulator of neuronal and immunological signaling, and photopharmacology offers a route to control nicotinic transmission with high spatiotemporal precision. Here we report CPZ-2...
Corrigendum to "Ruyiping extract reduces lung metastasis in triple negative breast cancer by regulating macrophage polarization" [Biomed. Pharmacother. 141 (2021) 111883] [0.03%]
“瑞uyoing提取物通过调节巨噬细胞极化减少三阴性乳腺癌肺转移”补遗
Rui Yang,Ying Xie,Qiong Li et al.
Rui Yang et al.
Microfluidic human liver slices reveal antifibrotic effects of liraglutide via HSC deactivation and ECM remodeling [0.03%]
微流控人肝切片揭示利拉鲁肽通过活化HSC和ECM重塑的抗纤维化作用
María Andrés-Rozas,Peio Aristu-Zabalza,Gabriela Chullo et al.
María Andrés-Rozas et al.
Background and aims: Extracellular matrix (ECM) remodeling is a key driver of chronic liver disease (CLD) progression. Precision-cut liver slices (PCLS) offer a relevant ex vivo model, but their short-term viability under...
Corrigendum to "Targeting PD-L1 and disrupting Siglec-9 cooperatively potentiate macrophage phagocytosis of breast cancer via a trispecific macrophage engager (TriME)" [Biomed. Pharmacother. 200 (2026), 119609] [0.03%]
关于“靶向PD-L1和破坏Siglec-9通过三特异性巨噬细胞 engager（TriME）协同增强乳腺癌的巨噬细胞吞噬作用”[Biomed. Pharmacother. 200 (2026), 119609]的勘误项
Saitong Muneekaew,Aussara Panya,Kritayaporn Saiprayong et al.
Saitong Muneekaew et al.
Targeted attenuation of liver fibrosis using microbubble-enhanced protease-activated receptor 1 chimeric antigen receptor T cells [0.03%]
载微泡的蛋白酶活化受体1嵌合抗原受T细胞在肝纤维化治疗中的应用研究
Hao-Chien Hung,Ainani Priza Minhalina,Po-Jung Hsu et al.
Hao-Chien Hung et al.
Background: Liver diseases account for a significant global mortality rate, with hepatic fibrosis representing a critical precursor to cirrhosis and liver cancer. Current therapeutic options remain limited, as no antifibr...
Euphol targets key oncogenic processes and promotes chemoprevention in organoid and In Vivo models of colorectal cancers [0.03%]
大黄素靶向关键致癌过程并促进结直肠癌类器官和活体模型的化学预防作用
Ana Laura Vieira Alves,Fahriye Duzagac,Myra Zaheer et al.
Ana Laura Vieira Alves et al.
Colorectal cancer (CRC) is a leading cause of cancer-related morbidity and mortality worldwide. Euphol, a triterpenoid alcohol derived from Euphorbia tirucalli, has demonstrated anti-tumor activity in various cancer cell lines; however, its...
CAR-T cell therapy and oncolytic viruses: A synergic approach for advanced GI cancers [0.03%]
CAR-T细胞治疗和溶瘤病毒：晚期胃肠道癌症的协同治疗方法
Seyed Kiarash Aghayan,Amin Azizan,Hadi Esmaeili Gouvarchin Ghaleh et al.
Seyed Kiarash Aghayan et al.
Gastrointestinal (GI) cancers remain a leading cause of cancer-related mortality worldwide, largely due to high recurrence rates, and limited responsiveness to existing systemic therapies. Although immunotherapy has transformed the manageme...