Two cinnamic acid derivatives as inhibitors of Pseudomonas aeruginosa las and pqs quorum-sensing systems: Impact on biofilm formation and virulence factors [0.03%]
两种肉桂酸衍生物作为铜绿假单胞菌las和pqs群体感应系统的抑制剂：对生物被膜形成及毒力因子的影响
Miguel M Leitão,Ariana S C Gonçalves,Sérgio F Sousa et al.
Miguel M Leitão et al.
Introduction: Quorum sensing (QS) is a bacterial communication mechanism that regulates gene expression, playing a crucial role in various physiological processes. Interfering with this signalling pathway is a promising s...
Duloxetine improves hyperosmia in mice with pancreatic cancer by increasing dopamine levels in the olfactory bulb [0.03%]
度洛西汀通过增加嗅球多巴胺水平改善胰腺癌小鼠的嗅觉过敏症状
Tomoya Kuramochi,Tomoaki Itaya,Yukino Oshima et al.
Tomoya Kuramochi et al.
The mechanism and therapeutic insights regarding hyperosmia to food odors in patients with cancer are poorly understood. We therefore evaluated the mechanism and effect of duloxetine in KPPC (LSL-KrasG12D/+; Trp53flox/flox; Pdx-1cre/+) mice...
Transforming growth factor-β receptor I kinase plays a crucial role in oligodendrocyte regeneration after demyelination [0.03%]
转化生长因子-β受体I激酶在脱髓鞘后少突胶质细胞再生中起关键作用
Yunkyoung Lee,Inyoung Jung,Dong-Won Lee et al.
Yunkyoung Lee et al.
Multiple sclerosis (MS) is an autoimmune disease characterized by the loss of oligodendrocytes (OLs) and axon demyelination in the central nervous system. Most therapeutic agents focus on regulating the immune response by suppressing autoim...
Mitochondria-targeted rosmarinic acid: Its role against oxidative damage [0.03%]
靶向线粒体的鼠李糖酸：其对抗氧化损伤的作用
Antonella Girgenti,Pasquale Picone,Miriam Buttacavoli et al.
Antonella Girgenti et al.
Mitochondria plays a key role in the physiological function of neurons, and alteration of this organelle results in severe and irreversible cell damage. Altered mitochondrial activity usually leads to cell degeneration that compromises the ...
Mitigation of nicotine-induced podocyte injury through inhibition of thioredoxin interacting protein [0.03%]
通过抑制硫氧还蛋白相互作用蛋白缓解尼古丁所致足细胞损伤
Sayantap Datta,Mohammad Atiqur Rahman,Saisudha Koka et al.
Sayantap Datta et al.
Nicotine has been reported to initiate NLRP3 inflammasome formation and activation in different pathological conditions. The current study assessed whether thioredoxin-interacting protein (TXNIP) mediates nicotine-induced NLRP3 inflammasome...
Lipid metabolism in cancer: Exploring phospholipids as potential biomarkers [0.03%]
癌症中的脂质代谢：探索磷脂作为潜在生物标志物的可能性
Dominique Delmas,Aurélie Mialhe,Alexia K Cotte et al.
Dominique Delmas et al.
Aberrant lipid metabolism is increasingly recognized as a hallmark of cancer, contributing to tumor growth, metastatic dissemination, and resistance to therapy. Cancer cells reprogram key metabolic pathways-including de novo lipogenesis, li...
Corrigendum to "(+)-Terrein exerts anti-obesity and anti-diabetic effects by regulating the differentiation and thermogenesis of brown adipocytes in mice fed a high-fat diet" [Biomed. Pharmacother. 186 (2025) 118030] [0.03%]
“(+)-Terrine通过调节高脂饮食喂养的小鼠棕色脂肪细胞的分化和产热来发挥抗肥胖和抗糖尿病作用”的勘误项
Haruka Aoki-Saito,Hiroki Mandai,Takashi Nakakura et al.
Haruka Aoki-Saito et al.
Methyleugenol alleviates pulmonary vascular remodeling in rats with high-altitude pulmonary hypertension by improving pulmonary smooth muscle cell function [0.03%]
甲基丁香酚通过改善肺平滑肌细胞功能缓解高原肺动脉高压大鼠肺血管重构
Yang Yu,Yurong Wang,Ziqi Yang et al.
Yang Yu et al.
Pulmonary hypertension is divided into five groups, and chronic exposure to hypoxia causes pulmonary hypertension in the third group -- high altitude pulmonary hypertension, which is commonly seen in patients with chronic obstructive pulmon...
HG043, a potent thienopyrimidine GPR119 agonist, demonstrates enhanced anti-diabetic and anti-obesity effects in preclinical models [0.03%]
HG043，一种有效的噻二吡啶类GPR119激动剂，在糖尿病和肥胖症动物模型中展现出增强的药效作用
Sangdon Lee,Heecheol Kim,Inyoung Choi et al.
Sangdon Lee et al.
GPR119 is a promising therapeutic target for type 2 diabetes because of its role in enhancing glucose-stimulated insulin secretion and GLP-1 release. We investigated the anti-diabetic and anti-obesity effects of HG043, a novel and potent th...
C Alarcón-Veleiro,I López-Calvo,L Berjawi et al.
C Alarcón-Veleiro et al.
Ferroptosis is a regulated form of cell death characterised by iron-dependent lipid peroxidation, a process intricately linked to cellular redox homeostasis. This form of cell death is induced by the accumulation of intracellular iron and t...