Aerobic conditioning and ginsenoside modulation modify molecular resilience in middle-aged rats: Differential effects of individual and combined interventions [0.03%]
有氧锻炼和人参皂苷调节可改变中年大鼠的分子耐受性：个体及联合干预的不同效果
Zahra Olfat Noubari,Jabbar Bashiri,Mohammad Mostafa Pourseif et al.
Zahra Olfat Noubari et al.
Hippocampal aging is characterized by early cognitive decline, disrupted redox homeostasis, and shifts in amyloid processing. This study evaluated the modulatory effects of aerobic exercise and ginseng supplementation, both individually and...
Cardioprotective potential of Fridericia platyphylla (Cham.) L.G. Lohmann: Phytochemical characterization and experimental evidence [0.03%]
弗迪里西亚属植物的心脏保护潜力：药理成分表征和实验证据
Andressa Coelho Ferreira,Raphael Furtado Marques,Jhonata Costa Moura et al.
Andressa Coelho Ferreira et al.
Background: The isoproterenol (ISO)-induced myocardial injury (MI) model is widely used to investigate cardioprotective strategies in the context of sustained β-adrenergic overstimulation, oxidative stress, and disruptio...
DDAH1 and DDAH2 drive vasculogenic mimicry and more aggressive phenotypes in triple negative breast cancer cells [0.03%]
DDAH1和DDAH2通过血管生成模仿驱动三阴性乳腺癌细胞的更恶性的表型
Jai Meyers,Lashika Weerakoon,Vinitha Ragavan et al.
Jai Meyers et al.
The overexpression of dimethylarginine dimethylaminohydrolase 1 (DDAH1) and 2 (DDAH2) has been associated with several types of cancer. Specifically, DDAH1 has been shown to play a critical role in the establishment of a vascular network by...
Antitumor efficacy of repurposed phenformin in preclinical models of epithelial ovarian cancer [0.03%]
临床卵巢癌上皮模型中再利用药物苯甲福明的抗肿瘤疗效
Jihye Kim,Ju-Yeon Choi,Jun-Hyeong Seo et al.
Jihye Kim et al.
Phenformin is a biguanide-class antidiabetic drug and has demonstrated anticancer activity in various malignancies. Epithelial ovarian cancer (EOC), which often develops chemoresistance, remains a lethal disease with a poor prognosis. While...
RGD-functionalized cannabidiol lipid nanoparticles improve brain delivery and alleviate cognitive and metabolic dysfunction via gut-brain axis modulation in an Alzheimer's disease model [0.03%]
经RGD功能化的 cannabidiol 脂质纳米粒通过调节阿尔茨海默病模型的脑肠轴改善大脑递送以及认知和代谢障碍
Sarawut Lapmanee,Natchayaporn Thonapan,Siriwan Sriwong et al.
Sarawut Lapmanee et al.
Background: Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline and neuronal loss. Evidence links gut-brain axis dysfunction and metabolic disturbances to AD. Although c...
Effect of electron beam irradiation of piroxicam on inhibiting the inflammatory response in LPS-stimulated BMDCs and sepsis-induced mouse models [0.03%]
电子束照射对吡罗昔康抗LPS刺激BMDCs炎症反应及脓毒症小鼠模型的作用效果研究
Bo-Gyeong Yoo,Gyeong Han Jeong,Ha-Yeon Song et al.
Bo-Gyeong Yoo et al.
Non-steroidal anti-inflammatory drugs (NSAIDs), such as piroxicam (PX), are widely used but are limited by gastrointestinal and hepatic toxicity. Electron beam (e-beam) irradiation can induce structural diversification of small molecules, p...
Unleashing the prospects of nanomaterials in the treatment of autoimmune and inflammatory diseases [0.03%]
纳米材料在自身免疫和炎症疾病治疗中的前景展望
Vijayakumar G Gayathri,P Abdul Rasheed,Jagadeesh Bayry
Vijayakumar G Gayathri
Autoimmune diseases arise when the immune system, responsible for safeguarding the body against infections and other foreign agents mistakenly attacks healthy cells and tissues. This leads to acute and chronic inflammation, tissue damage, a...
Extracellular vesicle depletion improves transient gene expression performance and alters cellular transcriptional responses in CHO cell [0.03%]
去除细胞培养上清中胞外囊泡可提高CHO细胞瞬时表达效率并改变其转录组反应
Marzia Rahimi,Pol Pérez-Rubio,Juliana Vargas-Gracia et al.
Marzia Rahimi et al.
Chinese hamster ovary (CHO) cells are widely used for the production of recombinant biologics, but their application in transient gene expression (TGE) systems remains limited by reduced efficiency at high cell density, known as the cell de...
From diabetic foot to dementia: A neurovascular continuum linking systemic diabetic vasculopathy, cerebral small vessel disease, and glymphatic dysfunction [0.03%]
从糖尿病足到痴呆：系统性糖尿病血管病、脑小血管病和胶淋巴运输障碍的神经血管连续带理论
Yuriko Inoue,Tatsunori Oguchi,Akio Inoue et al.
Yuriko Inoue et al.
Diabetes mellitus, particularly type 2 diabetes mellitus (T2DM), is increasingly recognized as a major risk factor for cognitive decline and dementia. Epidemiological studies consistently demonstrate that individuals with diabetes exhibit a...
Acid sphingomyelinase is an age-dependent host cell factor for adenovirus entry and a pharmacological target for synergistic combination therapy with brincidofovir [0.03%]
酸性鞘氨醇磷酸脂酶是衰老依赖的腺病毒侵染宿主细胞因子及溴西多福韦协同治疗作用靶点
Sophie Post,Mohamed Zamzamy,Luca Benthien et al.
Sophie Post et al.
Endolysosomal compartments act as critical sorting hubs for viral entry, trafficking, and uncoating, yet the contribution of lipid-modifying enzymes to these processes remains incompletely understood. Acid sphingomyelinase (ASM), a key regu...