2',6'-dihydroxy-3',4'-dimethoxydihydrochalcone counteracts cancer multidrug resistance by impeding STAT3 activation and ABC transporter-mediated drug efflux [0.03%]
2’,6’-二羟基-3’,4’-二甲氧基二氢查耳酮通过抑制STAT3活化和ABC转运体介导的药物外排对抗癌多药耐药性
Po-Yu Chien,Yu-Ning Teng,Yu-Hsuan Lan et al.
Po-Yu Chien et al.
Multidrug resistance (MDR) is a major obstacle to current cancer treatment, driven by complex and multifaceted mechanisms. To date, no targeted therapy has been successfully developed to overcome MDR in oncology. In this study, we identify ...
Design, development and evaluation of a tritium-labeled radiotracer for ecto-5'-nucleotidase (CD73) - A versatile research tool and diagnostic agent for personalized medicine [0.03%]
用于ecto-5′-核苷酸酶(CD73)的放射示踪剂的设计、开发与评估——一种个性医学研究工具及诊断试剂
Riham M Idris,Haneen Al-Hroub,Constanze C Schmies et al.
Riham M Idris et al.
Ecto-5'-nucleotidase (CD73) is the main enzyme that catalyzes the hydrolysis of extracellular AMP to produce anti-inflammatory, immunosuppressive adenosine. Many tumor cells over-express ectonucleotidases accumulating adenosine in the tumor...
Obesity-related drug-metabolizing enzyme expression alterations in the human liver [0.03%]
人肝药物代谢酶在肥胖相关表达的变化
Katarzyna Kosicka-Noworzyń,Aleksandra Romaniuk-Drapała,Yi-Hua Sheng et al.
Katarzyna Kosicka-Noworzyń et al.
Objective: Implications of obesity extend beyond the association with various health conditions, impacting physiological changes that affect the liver and the activity of metabolizing enzymes. Given the prevalence of obes...
Daidzein effectively mitigates amyloid-β-induced damage in SH-SY5Y neuroblastoma cells and C6 glioma cells [0.03%]
大豆异黄酮daidzein有效缓解amyloid-β引起的神经元和胶质细胞损伤
Alp Yiğit Özdemir,Esin Akbay Çetin,Jiří Novotný et al.
Alp Yiğit Özdemir et al.
Alzheimer's disease (AD) is the most debilitating form of dementia, characterized by amyloid-β (Aβ)-related toxic mechanisms such as oxidative stress, neuroinflammation, and mitochondrial dysfunction. The development of AD is influenced b...
Polyphyllin I induces ferritinophagy dependent ferroptosis through EZH2 and promotes anti-tumor immunity [0.03%]
polyphyllin I通过EZH2诱导依赖于铁死亡的 ferritinophagy并促进抗肿瘤免疫反应
Mengfei Xu,Xiaoyan Yu,Luyu Jia et al.
Mengfei Xu et al.
Background: Polyphyllin I (PPI), the primary active component extracted from the commonly utilized drug Paris polyphylla, in clinical applications, exhibits exceptional anti-tumor activity. Therefore, the objective of thi...
Fucoxanthin supplemented combinatorial treatment accelerates diabetic wound healing in rats by targeting hypermethylation of Ang-1 promoter via DNMT-1 inhibition [0.03%]
岩藻黄素通过DNMT-1抑制靶向Ang-1启动子高甲基化促进糖尿病大鼠创面愈合的协同治疗研究
Kaarthik Saravanan,Reena Rajkumari Baskaran
Kaarthik Saravanan
It has been widely established that DNA methyl transferase 1 has a role in the epigenetic regulation of numerous complications including diabetes and inhibition of the same is widely being seen as a potential therapeutic mechanism to treat ...
Pharmacological modulation of neutrophils, in contrast to that of macrophages/microglia, is sex independent and delays the development of morphine tolerance in a mouse model of neuropathic pain [0.03%]
药理学调节中性粒细胞与巨噬细胞/小胶质细胞相反，性别独立，并延迟了在神经病理性疼痛的小鼠模型中吗啡耐受的发展
Katarzyna Pawlik,Katarzyna Ciapała,Agata Ciechanowska et al.
Katarzyna Pawlik et al.
Identifying sex-specific mechanisms underlying neuropathic pain, as well as its therapy, remains a challenge. Recent studies suggest important roles for neutrophils, macrophages and microglia in the development of hypersensitivity and the m...
Methylene blue as a potential intervention in sepsis: Effects on survival and microcirculation in rat models of sepsis [0.03%]
亚甲蓝作为潜在的抗感染干预手段对其它模型中脓毒血症大鼠生存率及微循环的影响研究
Fabiola Mestriner,Pedro Brüch Dantas,Jessyca Michelon-Barbosa et al.
Fabiola Mestriner et al.
Sepsis is a life-threatening condition characterized by systemic inflammation and microcirculatory dysfunction. Methylene blue (MB), a compound with known antioxidant and anti-inflammatory properties, has been proposed as a potential therap...
Effects of maternal drinking patterns and epigallocatechin-3-gallate treatment on behavioural and molecular outcomes in a mouse model of fetal alcohol spectrum disorders [0.03%]
母体饮酒模式及表没食子儿茶素-3-没酯干预对小鼠胎儿酒精谱系障碍模型行为及分子结局的影响
Melina Vieiros,Laura Almeida-Toledano,Mariona Serra-Delgado et al.
Melina Vieiros et al.
Prenatal alcohol exposure (PAE) impairs fetal development leading to fetal alcohol spectrum disorders (FASD). Antioxidants like epigallocatechin-3-gallate (EGCG) may mitigate alcohol-induced oxidative stress, a major contributor to FASD. Th...
Antigen presentation potential is variable among human ovarian tumour and syngeneic murine models and dictates pre-clinical outcomes of immunotherapy [0.03%]
人卵巢癌和同基因小鼠模型的抗原呈递潜能存在差异，并决定了免疫治疗的预临床结果
Louisa Alim,Siddharth Adityan,Rui Chen et al.
Louisa Alim et al.
High grade serous ovarian carcinoma (HGSC) is a fatal gynaecological malignancy with limited therapeutic options. Immunotherapies targeting MHC-I-dependent antigen presentation offer potential. Currently, the antigen presentation machinery ...