Engineered PEA-producing Lactobacillus paracasei F19 prevents colitis-associated colorectal cancer in mice by modulating inflammatory-angiogenic signaling and beneficially reshapes gut microbiota composition [0.03%]
工程化产生PEA的乳酸菌F19通过调节炎性血管生成信号预防小鼠结肠炎相关结直肠癌并重塑肠道微生物群组成
Irene Palenca,Walter Sanseverino,Roberto Malinverni et al.
Irene Palenca et al.
Colitis-associated colorectal cancer (CAC) arises from the interplay between chronic inflammation, epithelial dysregulation, angiogenesis, and microbiota alterations. Palmitoylethanolamide (PEA) is an endogenous lipid mediator with anti-inf...
Microglial immunometabolism in Alzheimer's disease: A stage-resolved trajectory from adaptive remodeling to the metabolic paradox [0.03%]
阿尔茨海默病中小胶质细胞免疫代谢：从适应性重塑到代谢悖论的阶段化解析轨迹
Yue Zou,Yi Ou,Hang Zhao et al.
Yue Zou et al.
Microglia are central regulators of the cellular phase of Alzheimer's disease (AD). Under chronic exposure to amyloid-β, pathological tau, and aging-associated bioenergetic decline, these cells undergo immunometabolic remodeling that may i...
Mitochondrial bioenergetic remodeling underlies fingolimod-induced immunometabolic adaptation in multiple sclerosis [0.03%]
芬戈莫德通过线粒体生物能重塑诱导多发性硬化免疫代谢重编程
Adela González-Jiménez,Pilar López-Cotarelo,Alba Moreno-Jerez et al.
Adela González-Jiménez et al.
Mitochondrial dysfunction and immune cell metabolic reprogramming are central mechanisms driving the pathogenesis and progression of multiple sclerosis (MS). Fingolimod (FTY720), a sphingosine-1-phosphate analog widely used in MS, limits ly...
Irreversible cell electroporation-induced release of DAMPs increases cancer cell resistance to electroporation [0.03%]
不可逆细胞电穿孔诱导的DAMPs释放可增加癌细胞对电穿孔的抗性
B Jakštys,S Vykertas,R Palepšienė et al.
B Jakštys et al.
Irreversible electroporation (IRE) utilizes high-voltage pulses to permeabilize cell membranes and induce cancer cell death, a process that releases damage-associated molecular patterns (DAMPs) and triggers immune responses. This study inve...
Tetracyclic triterpenes from Chios Mastic Gum act as TGR5 and RORγ modulators [0.03%]
土耳其奇奥斯乳香树皮中四环三萜类化合物作为TGR5和RORγ调节剂的作用
Alexander F Perhal,Lorenza Bertaina,Jorge Enrique Hernández González et al.
Alexander F Perhal et al.
Background: Chios mastic gum (CMG) is a natural resin from Pistacia lentiscus L. var. Chia (Anacardiaceae). It contains high concentrations of triterpenoids, with 24Z-masticadienonic acid (24Z-MNA) and 24Z-isomasticadieno...
Therapeutic targeting of folate receptor alpha (FRα) by antibody-polymer-drug conjugate in testicular germ cell tumors [0.03%]
叶酸受体α(FRα)抗体-聚合物-药物偶联物在睾丸生殖细胞肿瘤治疗中的作用研究
Lucia Kučerová,Robert Pola,Marcela Filipová et al.
Lucia Kučerová et al.
Antibody-drug conjugates (ADCs) are an effective treatment for recurrent/refractory testicular germ cell tumors (rrTGCTs). In this exploratory study, we report disease stabilization achieved with the ADC Mirvetuximab soravtansine (MIRV) in ...
Insulin resistance as a driver of neuroinflammation and oxidative stress in Alzheimer's disease: Mechanistic links and therapeutic approaches [0.03%]
胰岛素抵抗在阿尔茨海默病中的作用：驱动神经炎症和氧化应激的机制联系及治疗策略
Parinaz Hajeforoosh,Akbar Hajizadeh Moghaddam,Sedigheh Khanjani Jelodar
Parinaz Hajeforoosh
Alzheimer's disease (AD) is a complex, multifactorial neurodegenerative disorder characterized by the accumulation of amyloid-β plaques and hyperphosphorylated tau protein aggregates, leading to progressive cognitive decline. Growing evide...
Real-time breath metabolomic profiling reveals a volatile signature associated with lung cancer [0.03%]
实时呼吸代谢组学监测发现肺癌相关挥发性标志物
Kai Fricke,Jonas Herth,Diego M Baur et al.
Kai Fricke et al.
Background: Real-time breath metabolomic profiling may detect lung cancer-associated breath features, but exploratory case-control findings require cautious interpretation because small cohorts are susceptible to overfitt...
Therapeutic Salmonella expressing apoptin and CEA elicits combined pro-apoptotic and immune-mediated anticancer effects [0.03%]
表达凋亡素和CEA的治疗性沙门菌产生协同促凋亡和免疫介导的抗肿瘤效应
Jun Kwon,Ram Aganja Prasad,Muhammad Bakhsh et al.
Jun Kwon et al.
In the current study, we genetically engineered Salmonella Typhimurium to serve a dual purpose in cancer immunotherapy, simultaneously inducing apoptosis and activating anti-cancer immune responses. Tumor-residing tryptophan auxotrophic Sal...
Antitrypanosomatid and antiamitochondriate activity of new cyclohexyl-quinoxaline-7-carboxylate-1,4-di-N-oxide derivatives: An in silico and in vitro approach toward the elucidation of their mechanisms of action [0.03%]
新的环己基-喹唑啉-7-甲酸衍生物的抗锥虫和抗线粒体活性：一种通过计算方法和体外方法阐明其作用机制的方法
Alonzo González-González,Lilian Yépez-Mulia,Adriana Moreno-Rodríguez et al.
Alonzo González-González et al.
A new series of cyclohexyl-quinoxaline-7-carboxylate-1,4-di-N-oxide derivatives was synthesized and evaluated in vitro against the trypanosomatids Trypanosoma cruzi and Leishmania mexicana, and the amitochondriates Giardia lamblia, Trichomo...