Comparative Analysis of Septin Modifiers, Forchlorfenuron and UR214-9, on Mitochondrial Fragmentation and Lytic Cell Death [0.03%]
秋水仙素和UR214-9修饰物对线粒体碎裂和细胞溶解性细胞死亡的比较分析
Dominik Brokatzky,Rajdeep Das,Hannah Painter et al.
Dominik Brokatzky et al.
Septins are conserved GTP-binding proteins that play key roles in cell division, mitochondrial dynamics and immune responses. Despite their importance to human health, pharmacological compounds to modify septins remain limited. Forchlorfenu...
Discovery of an Atypical Arp2/3 Complex in Malaria Parasites Sheds New Light on Nuclear Actin [0.03%]
疟原虫中的非典型ARP2/3复合体的发现揭示了细胞核内肌动蛋白的新信息
Franziska Hentzschel,Friedrich Frischknecht,Matthias Marti
Franziska Hentzschel
The Arp2/3 complex is a key actin nucleator essential for cytoskeletal dynamics in eukaryotes. Previously believed absent in apicomplexan parasites, we recently identified an atypical Arp2/3 complex in malaria parasites consisting of five d...
Evidence for Motility Determinants in the Kinesin-1 Minimal Motor Core Domain From Tether Variations [0.03%]
基于系绳变化的Kinesin-1最小马达核心结构域中运动决定因素的证据
Rieko Sumiyoshi,Masahiko Yamagishi,Junichiro Yajima
Rieko Sumiyoshi
Kinesin-1 is a dimeric motor protein that moves towards the microtubule plus-end in a hand-over-hand fashion. However, the minimal motor domain of kinesin-1 is a single head, and the mechanism by which minimal motor domains generate the for...
Centrosome-Signaling Pathway Crosstalk: A Core Hub From Cellular Homeostasis to Disease [0.03%]
中心体信号通路交叉对话：从细胞稳态到疾病的核心节点
Mingyu Pan,Jinghan Li,Jingyan Fu
Mingyu Pan
The centrosome, an evolutionarily conserved organelle in most animal cells, plays a pivotal role in fundamental processes such as cell division and ciliogenesis. Recent evidence increasingly highlights active crosstalk between the centrosom...
Marin Herrick
Marin Herrick
Rosa Guerra
Rosa Guerra
Post-LECA Origin and Diversification of an Axonemal Outer Arm Dynein Motor [0.03%]
着丝粒前起源和轴突外臂动力蛋白的多样化
Stephen M King
Stephen M King
Dyneins were present in the last eukaryotic common ancestor (LECA) and play key roles in eukaryotic biology. Axonemal dyneins form the inner and outer arms that power ciliary beating, and it has long been recognized that outer arms in some ...
Xunshuo Liu,Fangyuan Liu,Shanshan Nai
Xunshuo Liu
In animal cells, centrosomes function as the microtubule-organizing centers; their presence is essential for mitosis and for assembling various cilia-both primary and motile. Here, we identified coiled-coil domain containing 81 (CCDC81) loc...
Agent-Based Computational Modeling of the Stochastic Dynamic Behavior of Actin Filaments Recapitulates the Homeostatic Cortical Array in Plant Epidermal Cells [0.03%]
基于代理的计算建模再现了植物表皮细胞中肌动蛋白丝的稳态皮层排列及其随机动态行为
June Hyung Kim,Weiwei Zhang,Anjali Iyer-Pascuzzi et al.
June Hyung Kim et al.
The homeostatic cortical actin array in plant cells plays important roles in fundamental processes, including intracellular transport, secretion, cell expansion, and cytoplasmic streaming. In response to diverse chemical and mechanical sign...