Determining Proximities of Sarcomeric Proteins in Living Skeletal Muscle Cells Using FRET Imaging [0.03%]
利用FRET成像技术测定活体骨骼肌细胞中细肌丝蛋白间的相对距离
Jushuo Wang,Yingli Fan,Vasundhara Muthu et al.
Jushuo Wang et al.
The technique of fluorescence resonance energy transfer (FRET) has been used in this study to determine the proximities (efficiencies, i.e., E%) of interacting proteins in sarcomeres in living cultured embryonic chicken skeletal muscle cell...
Cytoskeleton-Membrane Uncoupling in Duchenne Muscular Dystrophy: Implications for Newborn Screening and Early Protection [0.03%]
杜氏肌营养不良中细胞骨架-膜解耦的含义及新生儿筛查和早期保护措施的影响
Houda Cohen,Nora Hosny,Brian R Thompson et al.
Houda Cohen et al.
The cytoskeleton of striated muscle integrates force transmission, mechanotransduction, and sarcolemmal stability through coordinated networks of sarcomeres, costameres, and intermediate filaments. Together, these systems establish mechanic...
Microtubule Destabilizing Kinesins: A Historical Perspective and Thoughts for the Future [0.03%]
解聚微管的马达蛋白动力蛋白：历史回顾与未来思考
Claire E Walczak
Claire E Walczak
The microtubule cytoskeleton plays critical roles in multiple cellular processes such as mitotic spindle assembly and chromosome segregation. Cells contain a number of microtubule-associated proteins that regulate microtubule dynamics both ...
Author Profile: Jia-Lin Zhu [0.03%]
作者简介：朱加林
Jia-Lin Zhu
Jia-Lin Zhu
Author Profile: Zhao Xie [0.03%]
作者简介：谢照
Zhao Xie
Zhao Xie
Henry De Belly
Henry De Belly
Author Profile: Mingyu Pan [0.03%]
作者简介：潘明宇
Mingyu Pan
Mingyu Pan
Lathan Lucas,My Diem Quan,Josephine C Ferreon et al.
Lathan Lucas et al.
Neurodegenerative diseases have largely been defined by the accumulation of misfolded and aggregated proteins, while cytoskeletal disruption has typically been treated as a secondary consequence of pathology. Here, we argue that tubulin and...
Beyond Binding Affinity: How a Conformation-Specific Salt Bridge Tunes KIF1A Mechanochemistry [0.03%]
超越亲和力：KIF1A分子马达构象特异性盐桥的作用机制及其机理研究
Abhipsa Shatarupa,Lu Rao,Arne Gennerich et al.
Abhipsa Shatarupa et al.
Mutations at KIF1A residue R350 are linked to hereditary spastic paraplegia type 30 (SPG30), part of the spectrum of KIF1A-associated neurological disorders (KAND). Recent high-resolution cryo-EM structures of the KIF1A R350G and R350W muta...