Introduction to the Special Issue "Centrosomes to Cilia: In Sickness and in Health" [0.03%]
特刊“从中心体到纤毛：疾病与健康”的前言
Priyanka Singh
Priyanka Singh
Jia-Lin Zhu,Xin Liang
Jia-Lin Zhu
Microtubules are highly adaptable cytoskeletal polymers whose dynamic nature supports a broad spectrum of cellular activities. Their dynamic behavior is regulated by an intricate network of factors, including tubulin isotypes and post-trans...
Prabhat Tiwari
Prabhat Tiwari
Titin Is Present in the Elastic Tethers That Connect Separating Anaphase Chromosomes in Crane-Fly Spermatocytes [0.03%]
棒脂蝇精原细胞分裂期染色体间的弹性纤维中含有Titin蛋白
Demetra Economopoulos,Maral Janan,Martina Krüger et al.
Demetra Economopoulos et al.
Elastic tethers connect telomeres of separating chromosomes in anaphase of animal cells. Immunofluorescence staining of titin in crane-fly spermatocytes, using 4 different antibodies, shows that the giant elastic protein titin seems to be a...
Structure Makes a Difference: IFT Complex in Ciliary Function and Ciliopathy [0.03%]
结构决定功能：IFT复合体与纤毛功能及纤毛病症
Ying Liu,Yong Zhang,Hua Ni et al.
Ying Liu et al.
Cilia, evolutionarily conserved organelles on eukaryotic cell surfaces, depend on the intraflagellar transport (IFT) system for their assembly, maintenance, and signaling. The IFT system orchestrates bidirectional trafficking of structural ...
O-GlcNAcylation of CEP44 Promotes Its Droplet Formation and Regulates Its Localization [0.03%]
O-GlcNAc酰化促进CEP44的液滴形成及其定位调控
Mingzheng Hu,Zihe Zhao,Jinqiong Wang et al.
Mingzheng Hu et al.
The centrosomal protein of 44 kDa (CEP44) is essential for centriole duplication, centrosome cohesion, and spindle integrity. It localizes to the proximal end of centrioles and associates with spindle microtubules. Liquid-liquid phase separ...
Tau-Derived Peptides Bearing Azobenzene on Side Chains for Light-Controllable Microtubule Polymerization [0.03%]
带有偶氮苯侧链的tau衍生肽用于光控微管聚合
Hiroshi Inaba,Misato Umayahara,Akira Kakugo et al.
Hiroshi Inaba et al.
The precise control of microtubule dynamics is essential for diverse cellular processes and is a promising target for optical regulation using photoresponsive molecules. In this study, we developed Tau-derived peptides bearing azobenzene mo...
ENKD1 Modulates Skin Elasticity Through Microtubule Stability Regulation [0.03%]
ENKD1通过微管稳定调节调控皮肤弹性
Dan Dong,Mingzheng Hu,Xiaofan Wu et al.
Dan Dong et al.
Skin elasticity is critical for maintaining skin function, yet the molecular mechanisms governing this process remain incompletely understood. Herein, we identify enkurin domain-containing protein 1 (ENKD1) as a key regulator of skin elasti...
Optineurin Localization at the Centrosome, Spindle, and Midbody Implies Its Role in Cell Division [0.03%]
Optineurin在中心体、纺锤体和收缩环中的定位提示其在细胞分裂中的作用
Ankan Chakraborty,Marie-Noelle Benassy,Dominique Weil et al.
Ankan Chakraborty et al.
Optineurin (OPTN), a multifunctional cytosolic protein, is recognized as an autophagy adaptor. Its association with neurodegenerative diseases, like ALS, triggered extensive research. OPTN has been found in intracellular organelles, includi...