Tristan Pepper
Tristan Pepper
Shrabani Halder
Shrabani Halder
Isoform Specificity of a Compound Targeting Actin Filaments Containing Tropomyosin Tpm1.8/1.9 [0.03%]
一种特异性靶向含TPM1.8 / 1.9基因产物的肌动蛋白丝的化合物的作用形式特异性
Jeff Hook,Edna C Hardeman,Peter W Gunning
Jeff Hook
The unbranched actin filaments in mammalian cells are usually composed of co-polymers of a specific tropomyosin isoform with actin. Genetic manipulation has revealed that the tropomyosins largely define the functional properties of actin fi...
A Cell Type-Specific Role for Tubb6 in Ciliogenesis of Xenopus Epidermal Multiciliated Cells [0.03%]
Tubb6在非洲爪蟾表皮多纤毛细胞形成中的特异性作用
Xiaolu Xu,Jean Ross,Fiona Clark et al.
Xiaolu Xu et al.
Cilia are microtubule-based organelles found on the surface of most eukaryotic cells. These microtubules are composed of α- and β-tubulin heterodimers, and different tubulin isotypes can confer distinct properties to microtubules. Despite...
The Cilia-Associated Protein CCDC89 Is Dispensable for Male Fertility in Mice [0.03%]
纤毛相关蛋白CCDC89在小鼠雄性生育中可有可无
Dehao Song,Qingchao Li,Yuqing Sun et al.
Dehao Song et al.
Cilia are microtubule-based organelles that protrude from the cell surface and are crucial for cellular sensory and motility functions. Defects in cilia are associated with various diseases, collectively known as ciliopathies. Although sing...
The New Nexin-Dynein Regulatory Complex Component CCDC153 Is Dispensable for Ciliary Motility and Fertility in Mice [0.03%]
新的 nexin-动力蛋白调节复合体组分CCDC153在小鼠纤毛运动性和生育能力中可有可无
Shanshan Nai,Yanjie Zheng,Xunshuo Liu et al.
Shanshan Nai et al.
The nexin-dynein regulatory complex (N-DRC) is an essential axonemal structure for ciliary and flagellar motility. Coiled-coil domain containing 153 (CCDC153) has recently been identified as a new N-DRC component in Tetrahymena thermophila....
Andrea Lacigová [0.03%]
安德烈亚·拉奇戈娃
Andrea Lacigová
Andrea Lacigová
Harshita Kasera
Harshita Kasera
Novel Pathogenic Biallelic Variants in KIAA0586 Expand the Variant Spectrum of Ciliopathies [0.03%]
KIAA0586新致病双等位基因变异体扩展了纤毛疾病变异谱系
Yue Shen,Ruida He,Chao Lu et al.
Yue Shen et al.
Joubert syndrome (JBTS) is a group of recessive neurodevelopmental disorders classified as a specific type of ciliopathy with genetic heterogeneity. JBTS23, a subtype of Joubert syndrome, is caused by variations in the KIAA0586 gene. In thi...
Molecular Insights Into the Differential Binding Affinity of Human Katanin Hexamer for C-Terminal Tails of β-Tubulin Isotypes [0.03%]
人katamin六聚体与β微管蛋白各亚型C末端肽结合的亲和力差异及分子机制
Purva Khodke,Vibhuti Saxena,Pruthanka Patil et al.
Purva Khodke et al.
Katanin is a microtubule-severing enzyme critical for cellular processes such as cell division, migration, signaling, and cellular homeostasis. Katanin, a heterodimeric protein composed of p60 and p80, exhibits ATPase activity that is stimu...