Detachment of the basal body from the sperm tail is not required to organize functional centrosomes during Drosophila embryogenesis [0.03%]
基底体脱离精子尾巴对于果蝇胚胎发生期间组织功能中心粒并非必需
Maria Giovanna Riparbelli,Giuliano Callaini
Maria Giovanna Riparbelli
The formation of the zygotic spindle at fertilization requires in most animals the central contribution of the sperm-inherited basal body that recruits maternal cytoplasmic components to assemble a functional centrosome. Although as a gener...
Localization of MglA, an essential gliding motility protein in Myxococcus xanthus [0.03%]
黏质细胞菌中滑动运动的必需蛋白MglA的定位研究
Jacek Patryn,Krisandra Allen,Katarzyna Dziewanowska et al.
Jacek Patryn et al.
MglA, a 22-kDa protein related to monomeric GTPases, is required for the normal operation of the A (Adventurous) and S (Social) motility and for multicellular development of Myxococcus xanthus. To determine how MglA controls A- and S-motili...
Functional roles of VASP phosphorylation in the regulation of chemotaxis and osmotic stress response [0.03%]
VASP磷酸化在调节趋化性和渗透压响应中的功能作用
Wan-Hsin Lin,Sharon E Nelson,Ryan J Hollingsworth et al.
Wan-Hsin Lin et al.
Vasodilator-stimulated phosphoprotein (VASP) plays crucial roles in controlling F-actin-driven processes and growing evidence indicates that VASP function is modulated by phosphorylation at multiple sites. However, the complexity of mammali...
The molecular basis of frictional loads in the in vitro motility assay with applications to the study of the loaded mechanochemistry of molecular motors [0.03%]
用于研究分子马达负载机械化学的体外肌动试验中的摩擦负荷的分子基础及其应用
Michael J Greenberg,Jeffrey R Moore
Michael J Greenberg
Molecular motors convert chemical energy into mechanical movement, generating forces necessary to accomplish an array of cellular functions. Since molecular motors generate force, they typically work under loaded conditions where the motor ...
The kinetics of force-induced cell reorganization depend on microtubules and actin [0.03%]
细胞力量诱导重构的动力学取决于微管和肌动蛋白
Alexandra M Goldyn,Peter Kaiser,Joachim P Spatz et al.
Alexandra M Goldyn et al.
The cytoskeleton is an important factor in the functional and structural adaption of cells to mechanical forces. In this study we investigated the impact of microtubules and the acto-myosin machinery on the kinetics of force-induced reorien...
Tumoral and tissue-specific expression of the major human beta-tubulin isotypes [0.03%]
人主要β微管蛋白异构体的肿瘤特异性及组织特异性表达式型研究
Luis J Leandro-García,Susanna Leskelä,Iñigo Landa et al.
Luis J Leandro-García et al.
The beta-tubulins are microtubule components encoded by a multigene family, which produces slightly different proteins with complex expression patterns. Several widely used anticancer drugs base their activity on beta-tubulin binding, micro...
Identification of focal adhesion kinase (FAK) and phosphatidylinositol 3-kinase (PI3-kinase) as Par3 partners by proteomic analysis [0.03%]
蛋白质组学分析鉴定出黏着斑激酶(FAK)和磷脂酰肌醇3-激酶(PI3-Kinase)为Par3的相互作用蛋白
Norimichi Itoh,Masanori Nakayama,Takashi Nishimura et al.
Norimichi Itoh et al.
Partition defective 3 (Par3) is involved in a variety of polarity events including establishment of apico-basal polarity of epithelial cell, axon/dendrite specification of neurons and directional migration of cells with front-rear polarity....
Sensing the mechanical state of the axoneme and integration of Ca2+ signaling by outer arm dynein [0.03%]
外周臂动力蛋白感应轴突丝的机械状态并整合Ca2+信号通路
Stephen M King
Stephen M King
Axonemal dyneins have been demonstrated to monitor the mechanical state of the axoneme and must also alter activity in response to various signaling pathways. The central pair/radial spoke systems are clearly involved in controlling inner d...
Phosphorylation motifs in the nonhelical domains of myosin heavy chain and paramyosin may negatively regulate assembly in Caenorhabditis elegans striated muscle [0.03%]
秀丽隐杆线虫条纹肌中肌球蛋白和para肌球蛋白非螺旋结构域中的磷酸化基序可能对其装配具有抑制作用
Pamela E Hoppe,Ronald J Heustis,Kelly A Flanagan et al.
Pamela E Hoppe et al.
We are interested in mechanisms that establish and maintain the highly ordered contractile apparatus of striated muscle. The homologous proteins myosin and paramyosin are the major structural components of thick filaments in invertebrate an...
Characterization of L-plastin interaction with beta integrin and its regulation by micro-calpain [0.03%]
L-Plastin与β整合素的相互作用及其被微钙粘蛋白调节的作用机制
E Le Goff,A Vallentin,P-O Harmand et al.
E Le Goff et al.
Recent evidences suggest that plastin/fimbrin is more than a simple actin cross-linking molecule. In this context and based on the fact that other members of the same family interact with transmembrane proteins, such as integrins, we have i...