Qian Lyu,Mingming Ma,Ting Song
Qian Lyu
Cilia are microtubule-based, highly specialized organelles that are indispensable for tissue and organ development. Failures in ciliogenesis underlie severe genetic disorders known as ciliopathies. Microfilaments, a major cytoskeletal compo...
Rylee E King
Rylee E King
Quantitative Characterization of Microtubule Ultrastructure Based on Single-Molecule Localization Microscopy [0.03%]
基于单分子定位显微镜的微管超微结构定量表征
Zhao Xie,Fen Hu,Mingxin Chen et al.
Zhao Xie et al.
Single-molecule localization microscopy (SMLM) enables visualization of cytoskeletal architecture at nanoscale, uncovering ultrastructural details obscured in conventional imaging. In this study, we present a quantitative framework for char...
Dpcd Induces Hydrocephalus Because of Partial Defects in the Inner Dynein Arms, With Abnormal Ciliary Motility [0.03%]
DPCD通过顶体臂部分缺陷和纤毛运动异常导致脑积水
Taiki Yamamoto,Kazuhito Takeuchi,Yuichi Nagata et al.
Taiki Yamamoto et al.
Primary ciliary dyskinesia (PCD) is a congenital disease caused by gene mutations linked to ciliary dysfunction. PCD causes different symptoms, including chronic sinusitis, infertility, situs inversus and hydrocephalus. Motile cilia on vent...
KIF14 as a Dual Microtubule/F-Actin Binding Protein Contributing to Cytokinesis [0.03%]
一种同时结合微管和肌动蛋白促进细胞分裂的蛋白质KIF14
Yajie Wang,Changjun Zhu
Yajie Wang
Cytokinesis, the final step of cell division, necessitates precise coordination between the microtubule-based central spindle and the actomyosin contractile ring. KIF14, a member of the kinesin-3 family of motor proteins, has emerged as a c...
Purification, Fluorescent Labeling, and Detyrosination of Mammalian Cell Tubulin for Biochemical Assays [0.03%]
哺乳动物细胞微管蛋白的纯化、荧光标记和脱酪胺修饰用于生化检测
Ezekiel C Thomas,Yang Yue,Morgan L Pimm et al.
Ezekiel C Thomas et al.
Microtubules play essential roles in numerous cellular processes. All microtubules are built from the protein tubulin, yet individual microtubules can differ spatially and temporally due to their tubulin isotype composition and post-transla...
Recombinant Monoclonal Antibodies for Detecting the Tubulin Post-Translational Modifications Glutamylation and Lysine-40 Acetylation [0.03%]
用于检测谷氨酰化和lysine-40乙酰化的重组单克隆抗体
Lynne Blasius,Ezekiel C Thomas,Erik H Collet et al.
Lynne Blasius et al.
Post-translational modifications (PTMs) to tubulin subunits in microtubule filaments are thought to comprise a component of the tubulin code that specifies microtubule functions in cell physiology and animal development. Acetylation of Lysi...
Itzhak Fischer
Itzhak Fischer
Microtubule Associated Protein MAP1B is expressed at high levels during the early development of the nervous system, playing important roles in axonal growth, neuronal migration, and branching, as well as dendritic spine morphogenesis and s...
Shengnan Zheng,Lingyun Nie,Ziyi Lu et al.
Shengnan Zheng et al.
Microtubule nucleation is a critical initiating step in microtubule assembly during the cell cycle. This fundamental process is primarily mediated by γ-tubulin-containing complexes, namely, the γ-tubulin small complex (γ-TuSC) and its hi...